A Study of Anemia Prevalence in CKD Patients on Maintenance Hemodialysis: A Single Centre Study

Rajaram,; Himanshu, V; Pankaj, Ritu

doi:10.18410/jebmh/2015/871

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…This finding was in concordance with the studies by BhattaS et al [14],Barde R et al [15], Hakim et al [12], and Bhattacharjee K et al [16].The prevalence of mild, moderate and severe anemia by WHO criteria [6] was 5.26%, 55.26%, and 39.48% respectively.…”

Section: Discussionsupporting

confidence: 91%

Hematological Profile and Serum Potassium Level in Patients of Chronic Renal Failure at a Tertiary Health Care Center

Yogi

Fiza

Godara³

et al. 2019

IJCBR

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Background: Chronic Kidney Disease (CKD) can be defined as an estimated glomerular Filtration Rate (eGFR) of less than ml/min/1.73 m2 for a minimum period of three months. CKD is commonly associated with various hematological abnormalities specially anemia. Aim: The present study was planned to assess the hematological variations in CKD patients as compared to healthy subjects. Method: Fifty patients diagnosed for CKD were enrolled for the study. Fifty age and sex matched healthy subjects constituted the control group. Result: On comparison of the hematological profile, it was observed that all enrolled CKD patients were anemic with a hemoglobin (Hb) less than 13g/dL in males and less than 12 g/dL in females. The mean Hb levels were as low as 7.50 + 1.55 g/dL (P< 0.0001). Correspondingly, total RBC count of CKD patients was also low. It was also observed that platelet count was slightly low among CKD patients. However the mean level was comparable with control group (P=NS). On further analysis, it was observed that among fifty CKD patients, 46% (n=23) suffered from severe anemia i.e. Hb < 7 gm/dL whereas 48% had moderate anemia i.e. Hb between 7-9.9 gm/dL. However, only 12 % (n=6) CKD patients suffered from thrombocytopenia i.e. platelets count < 1.50 lack/ cmm. Conclusion: Hematological abnormalities may lead to several associated morbidities and may pose a challenge for maintenance of overall health status for CKD patient. Hence, there is need to monitor hematological profile of CKD patients specially those on dialysis so that any abnormality can be detected and managed accordingly. Keywords: Chronic kidney disease, Anemia, Hematological changes, Potassium, Platelets.

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Section: Discussionsupporting

confidence: 91%

Hematological Profile and Serum Potassium Level in Patients of Chronic Renal Failure at a Tertiary Health Care Center

Yogi

Fiza

Godara³

et al. 2019

IJCBR

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“…In a study by Chakravarthi et al [12] mean hemoglobin level was 7.39 gm% as in studies by Bhattacharjee K et al [11] . Bhatta S et al [13] , Barde R et al [15] and Hakim et al [16] . Our study had 68.57% patients having normochromic normochromic anemia which is similar to ones in studies by Mudiyammanavara NR, et al [17] and George SV et al [14] .…”

Section: Discussionmentioning

confidence: 99%

A study of hematological profile in CKD patients who are undergoing hemodialysis in a tertiary health care institute

Jm¹,

Sharvani²

2021

Int. J. Clin. Diagn. Pathol.

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Chronic kidney disease is a major cause of morbidity and mortality in developing countries. These patients tend to have various hematological abnormalities especially anemia which needs prompt treatment. A cross sectional observational study was conducted to study various hematological abnormalities commonly found in chronic kidney disease patients who were undergoing hemodialysis for a minimum period of three months. The principal finding in this study was prevalence of anemia in all the patients studied. There was presence of significant number of abnormal cells in the peripheral smear like Burr cells, Macroovalocytes and fragmented RBCs. However white blood cell count, Platelet count, Bleeding time and Clotting time were within normal limits. With this study we could conclude that anemia is a major comorbidity in hemodialysis patients, which require detailed evaluation and management.

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“…Anemia is the most serious complication in CHP. It is found in 70% of these patients and is responsible of important degradation of quality of life [1][2][3] . In end stage renal insufficiency, anemia is a consequence of accumulation of toxic metabolites, ID, FID and reduced erythropoietin production by renal failure, this situation is also observed in patients with a glomerular filtration rate less than 40 mL/min/1.73 m 2 [4,5] .…”

Section: Introductionmentioning

confidence: 99%

“…It plays a role in the transport of oxygen, synthesis of ATP and ADP and regulation of the cell cycle [1] . ID is accentuated by chronic blood loss in hemodialysis patients and is found in about 47% of them [1,2] . In this case, iron stores and iron absorbed by enterocytes are insufficient to maintain a normal erythropoiesis.…”

Section: Introductionmentioning

confidence: 99%

“…FID is present in about 50% of CHP, it is considered as a complication of inflammatory states and the use of erythropoiesis stimulating agents [3,7] . In this situation, biochemical parameters (serum iron, total iron binding capacity and serum ferritin) are unable to be used in the determination of iron status [2,7] . A great interest was made to develop biological parameters permitting determination of iron status without being influenced by inflammatory state.…”

Section: Introductionmentioning

confidence: 99%

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Extended erythrocyte and reticulocyte parameters in the diagnosis of iron deficiency in hemodialysis patients

Bennaoum¹,

Adda²,

Chekkal³

et al. 2020

Chinese J Med Res

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Objective: Iron deficiency (ID) is a frequent complication in end stage renal insufficiency. These patients have to be diagnosed and treated to reduce the prevalence of anemia. Functional iron deficiency (FID) is a situation that can disrupt biochemical iron tests and mask an eventual association with ID. In this study, we tried to prove the ability of extended parameters of red cells and reticulocytes to diagnose ID without being influenced by FID. Design and methods: 164 chronic hemodialysis patients (CHP) in end stage renal disease were enrolled. Research parameters of red cells and reticulocytes determined on ADVIA 2120i were studied in the diagnosis of ID associated or not with chronic inflammation. Results: Parameters such as corpuscular hemoglobin of mature red cells (CHm), corpuscular hemoglobin of reticulocytes (CHr), cellular concentration of hemoglobin in mature red cells (CHCMm), cellular concentration of hemoglobin in reticulocytes (CHCMr) and percentage of microcytic and hypochromic red cells (HYMI) showed a high sensitivity to diagnose ID. However, the distinction of combined iron deficiency (CID) from other entities was not possible with all parameters. In chronic inflammatory states, the decrease of CHm, CHCMm and CHCMr with the rise of percentage hypochromic mature red cells (HYPOm) and reticulocytes (HYPOr) is in favor of CID. So, determination of inflammatory state is needed to complete research parameters of blood count in CHP. Conclusion: Extended erythrocyte and reticulocyte parameters can be useful to check iron status in CHP.

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A Study of Anemia Prevalence in CKD Patients on Maintenance Hemodialysis: A Single Centre Study

Cited by 4 publications

References 12 publications

Hematological Profile and Serum Potassium Level in Patients of Chronic Renal Failure at a Tertiary Health Care Center

Hematological Profile and Serum Potassium Level in Patients of Chronic Renal Failure at a Tertiary Health Care Center

A study of hematological profile in CKD patients who are undergoing hemodialysis in a tertiary health care institute

Extended erythrocyte and reticulocyte parameters in the diagnosis of iron deficiency in hemodialysis patients

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