A strut graft substitute consisting of a metal core and a polymer surface

Lagoa, Ana L. C.; Wedemeyer, Christian; Knoch, Marius von; Löer, F.; Epple, Matthias

doi:10.1007/s10856-006-0022-0

Cited by 12 publications

(5 citation statements)

References 28 publications

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“…Ti, TiO 2 and Ti-alloy combined with polyester coatings have been intensively studied to fabricate scaffolds. Lagoa et al 246 developed a partially biodegradable implant from titanium, polylactide, HA, and calcium carbonate. The implant presented mechanical stability, biocompatibility, and partial biodegradability.…”

Section: Methodsmentioning

confidence: 99%

Scaffold Design for Bone Regeneration

Polo-Corrales¹,

Latorre-Esteves²,

Ramı́rez-Vick³

2014

j. nanosci. nanotech.

768

502

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The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate lost bone, as demonstrated by the large number of bone graft procedures performed worldwide. The most common of these is the autograft, however, its use can lead to complications such as pain, infection, scarring, blood loss, and donor-site morbidity. The alternative is allografts, but they lack the osteoactive capacity of autografts and carry the risk of carrying infectious agents or immune rejection. Other approaches, such as the bone graft substitutes, have focused on improving the efficacy of bone grafts or other scaffolds by incorporating bone progenitor cells and growth factors to stimulate cells. An ideal bone graft or scaffold should be made of biomaterials that imitate the structure and properties of natural bone ECM, include osteoprogenitor cells and provide all the necessary environmental cues found in natural bone. However, creating living tissue constructs that are structurally, functionally and mechanically comparable to the natural bone has been a challenge so far. This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.

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Section: Methodsmentioning

confidence: 99%

Scaffold Design for Bone Regeneration

Polo-Corrales¹,

Latorre-Esteves²,

Ramı́rez-Vick³

2014

j. nanosci. nanotech.

768

502

View full text Add to dashboard Cite

show abstract

“…PLA synthetic polymers have also been utilized to create a partially degradable bone graft for supporting weak bone in proximal femur [82]. This biomaterials comprises of an outer elastic layer of d , l -PLA, HA and calcium carbonate with an inner layer of titanium dip-coated into solutions of PLLA with suspended calcium salts.…”

Section: Biodegradable Materialsmentioning

confidence: 99%

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

et al. 2015

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This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.

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“…as the inner surface (contacting the substrate) and a gradient of the materials in between, the desired balance between the mechanical properties and bio-conductivity can be achieved 110,114,115. In a similar manner, graded polymeric coatings or graded composite (polymer–bioceramic) coatings were employed to achieve gradient transitions in mechanical properties and degradation, where degradation of the coating can be programmed to match the bone ingrowth, ideally 116. Polymeric coatings can also be utilized as a controlled delivery vehicle of osteogenic factors that may enhance bone ingrowth.…”

Section: Metal or Bioceramic Materialsmentioning

confidence: 99%

Strategies and Applications for Incorporating Physical and Chemical Signal Gradients in Tissue Engineering

Singh

Berkland

Detamore

2008

Tissue Engineering Part B: Reviews

177

147

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From embryonic development to wound repair, concentration gradients of bioactive signaling molecules guide tissue formation and regeneration. Moreover, gradients in cellular and extracellular architecture as well as in mechanical properties are readily apparent in native tissues. Perhaps tissue engineers can take a cue from nature in attempting to regenerate tissues by incorporating gradients into engineering design strategies. Indeed, gradient-based approaches are an emerging trend in tissue engineering, standing in contrast to traditional approaches of homogeneous delivery of cells and/or growth factors using isotropic scaffolds. Gradients in tissue engineering lie at the intersection of three major paradigms in the field—biomimetic, interfacial, and functional tissue engineering—by combining physical (via biomaterial design) and chemical (with growth/differentiation factors and cell adhesion molecules) signal delivery to achieve a continuous transition in both structure and function. This review consolidates several key methodologies to generate gradients, some of which have never been employed in a tissue engineering application, and discusses strategies for incorporating these methods into tissue engineering and implant design. A key finding of this review was that two-dimensional physicochemical gradient substrates, which serve as excellent high-throughput screening tools for optimizing desired biomaterial properties, can be enhanced in the future by transitioning from two dimensions to three dimensions, which would enable studies of cell–protein–biomaterial interactions in a more native tissue–like environment. In addition, biomimetic tissue regeneration via combined delivery of graded physical and chemical signals appears to be a promising strategy for the regeneration of heterogeneous tissues and tissue interfaces. In the future, in vivo applications will shed more light on the performance of gradient-based mechanical integrity and signal delivery strategies compared to traditional tissue engineering approaches.

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A strut graft substitute consisting of a metal core and a polymer surface

Cited by 12 publications

References 28 publications

Scaffold Design for Bone Regeneration

Scaffold Design for Bone Regeneration

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

Strategies and Applications for Incorporating Physical and Chemical Signal Gradients in Tissue Engineering

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