A strain-programmed patch for the healing of diabetic wounds

Theocharidis, Georgios; Yuk, Hyunwoo; Roh, Heejung; Wang, Liu; Mezghani, Ikram; Wu, Jingjing; Kafanas, Antonios; Contreras, Mauricio; Sumpio, Brandon J.; Li, Zhuqing; Wang, Enya; Chen, Lihong; Guo, Chuan Fei; Jayaswal, Navin; Katopodi, Xanthi-Lida; Kalavros, Nikolaos; Nabzdyk, Christoph S.; Vlachos, Ioannis S.; Veves, Aristidis; Zhao, Xuanhe

doi:10.1038/s41551-022-00905-2

Cited by 133 publications

(115 citation statements)

References 79 publications

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“…Recently, adhesives using tough hydrogel and dry polymer film realized fast wet adhesion, providing strategies for developing wet adhesives. [6][7][8] A few bioinspired blood-resistant injectable tissue adhesives with improved wet adhesion performance also have been developed. [9][10][11] Some of these adhesives utilize hydrophobic moieties to repulse water from the tissue surface to achieve wet adhesion.…”

Section: Research Articlementioning

confidence: 99%

An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

Bian

Hao

Qiu

et al. 2022

Adv Funct Materials

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Injectable hydrogel adhesives integrating both rapid adhesion to wet tissues and anti‐swelling in humid environments are highly desired for fast hemostasis and wound sealing in surgical applications. Herein, utilizing the synergistic effect of thermo‐sensitive shrinkable nano‐micelle gelators and small molecular adhesive moieties, an injectable hydrogel with rapid‐adhesion and anti‐swelling properties (RAAS hydrogel) is fabricated. The RAAS hydrogel can undergo ultrafast gelation to achieve wet adhesion within 2 s of ultraviolet illumination and exhibit an outstanding anti‐swelling performance with non‐expansion of volume during the whole degradation process. It also presents good biocompatibility and low risk of hemolysis. Its fast hemostasis is demonstrated in diverse hemorrhage models with injuries in the liver, artery, heart, cranial vessel, and brain cortex in small animals. Importantly, its volume stability in humid internal environment can maintain the strong adhesion strength and avoid compression injury to spinal cord when applied for dura sealing. These data suggest that the injectable RAAS hydrogel holds potential for the applications of fast hemostasis and wound sealing with the benefits of stable adhesion and reducing the risk of tissue compression injury.

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Section: Research Articlementioning

confidence: 99%

An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

Bian

Hao

Qiu

et al. 2022

Adv Funct Materials

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“…Wound management remains a major healthcare burden worldwide due to the rising prevalence of traumatic injuries and chronic wounds in various pathophysiological conditions 1–3 . Generally, wound healing involves a sequence of highly ordered biological stages, including hemostasis, inflammation, angiogenesis, growth, and re‐epithelialization 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Bioceramic materials with ion‐mediated multifunctionality for wound healing

Wang

Tang

2022

Smart Medicine

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Regeneration of both anatomic and functional integrity of the skin tissues after injury represents a huge challenge considering the sophisticated healing process and variability of specific wounds. In the past decades, numerous efforts have been made to construct bioceramic‐based wound dressing materials with ion‐mediated multifunctionality for facilitating the healing process. In this review, the state‐of‐the‐art progress on bioceramic materials with ion‐mediated bioactivity for wound healing is summarized. Followed by a brief discussion on the bioceramic materials with ion‐mediated biological activities, the emerging bioceramic‐based materials are highlighted for wound healing applications owing to their ion‐mediated bioactivities, including anti‐infection function, angiogenic activity, improved skin appendage regeneration, antitumor effect, and so on. Finally, concluding remarks and future perspectives of bioceramic‐based wound dressing materials for clinical practice are briefly discussed.

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“…The key to wound management is achieving efficient wound healing. [1,2] For wounds where the edges can be attached, sutures Mechanical forces are the critical regulators of tissue repair. [15] Cells in vivo transmit and withstand internal and external mechanical forces through cell-cell adhesion and interaction with the extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that actively contracting hydrogels are able to regulate the polarization of macrophages from a pro-inflammatory phenotype (M1 type) to an anti-inflammatory phenotype (M2 type) to promote wound healing. [1,21,22] However, the molecular mechanism is not fully understood. We investigated the molecular characterization of mechanical contraction-mediated wound healing to reveal key signaling molecules in the contraction-mediated tissue healing process in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Novel Temperature‐Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK‐Mediated Mechanosensitivity

Huang

Jiang

et al. 2022

Adv Healthcare Materials

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Wound healing is a significant problem in clinical management. Various functional dressings are studied to promote wound healing through biochemical factors. They are generally expensive, complex to fabricate, and may adversely affect the wound. Mechanical forces are the critical regulators of tissue repair. Although contraction is shown to promote wound healing, the underlying mechanisms are not fully understood. In this study, a novel adhesive temperature‐sensitive mechanically active hydrogel with a simple and inexpensive preparation process is developed. The dressing is able to adhere to the wound surface and actively contract the wound in response to body temperature. This mechanical contraction enhances the proliferative activity of basal cells, reduces the inflammatory response of the wound, and promotes wound healing. Furthermore, RNA‐seq clarifies how the gene regulatory network is regulated by contraction. Finally, using pharmacological inhibitors, YAP and MEK are identified as the key signaling molecules for contraction‐mediated tissue healing in vivo.

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A strain-programmed patch for the healing of diabetic wounds

Cited by 133 publications

References 79 publications

An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

Bioceramic materials with ion‐mediated multifunctionality for wound healing

Novel Temperature‐Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK‐Mediated Mechanosensitivity

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