A strain difference in the time and mode of regression of the adrenal X zone in female mice

Shire, J. G. M.; Spickett, S. G.

doi:10.1016/0016-6480(68)90092-0

Cited by 22 publications

(15 citation statements)

References 28 publications

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“…The present results clearly demonstrate that the X zone morphology is different with combinations of the alleles at the a locus in the SM/J mouse, suggesting that this locus may be involved in morphogenesis of the X zone in addi tion to the E.v locus on chromosome 7 reported by Shire and Spickett [1968],…”

Section: Discussionmentioning

confidence: 52%

Genetic Association between Agouti Locus and Adrenal X Zone Morphology in SM/J Mice

Tanaka

Nakagawa

Matsubara

1994

Cells Tissues Organs

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We provide evidence for a genetic link between the adrenocortical X zone and the agouti (a) locus on chromosome 2 in the segregating inbred mouse strain SM/J. This strain has been established and maintained while keeping heterozygosity (A^w/a) at the a locus and is, therefore, of advantage in assessing the effects of these alleles upon physiological phenomena. In A^w/a (white-bellied agouti) or a/a (black) virgins, X zones were composed exclusively of nonvacuolated cells, while they contained vacuolated cells only in A^w/A^w. This suggested that the a locus might control the X zone morphology on the SM/J genetic background and that the a (nonagouti) allele is dominant in vacuolation of cells in this zone. The a locus might have a novel function in the control of the adrenocortical X zone cell turnover in addition to the well-known function controlling the coat color.

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Section: Discussionmentioning

confidence: 52%

Genetic Association between Agouti Locus and Adrenal X Zone Morphology in SM/J Mice

Tanaka

Nakagawa

Matsubara

1994

Cells Tissues Organs

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“…The main differences between strains involve the extent of vacuolation, which is an index of tissue lipid content [15,18,20,24]. Although it was recently reported that the agouti locus affects vacuolation [16,19], no statistical data were provided.…”

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confidence: 99%

“…Thus, the endocrinological characteristics of these four adrenocortical zones are well known. But, little studies have been conducted on agerelated changes in the morphology of these adrenocortical zones [1].Strain differences in the morphology of X zone degeneration have been observed between A/Cam and CBA/FaCam mice [15], C57BL/6By and BALB/cBy mice [8], C57BL/ 6JJms and DDD mice [18], and A/J and SM/J mice [19,20].The main differences between strains involve the extent of vacuolation, which is an index of tissue lipid content [15,18,20,24]. Although it was recently reported that the agouti locus affects vacuolation [16,19], no statistical data were provided.…”

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confidence: 99%

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A Morphometric Study of the Adrenal Cortex of the Female DDD Mouse

Tsujio

Mizorogi

Nishijima

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. The aim of this study was to determine whether the thickness of the adrenocortical zone is associated with age in virgin and parous female DDD mice. The zona reticularis and zona glomerulosa of parous mice tended to be thicker than those of virgin mice at all ages. The zona fasciculata lactating parous mice was significantly thicker than that of virgin mice at 20 weeks of age (P<0.01). Age did not affect the thickness of the three outer adrenocortical zones in either group. However, in virgin mice, the X zone consisted of vacuolated and nonvacuolated cells at 5 weeks of age and only of vacuolated cells at 10 weeks of age; the number of vacuolated cells and the thickness of the zone decreased at 40 weeks of age. In contrast, parous mice of all ages lacked an X zone. The decrease in X zone thickness with age was most evident when expressed relative to organ weight. In conclusion, the thickness of the outer three adrenocortical zones is affected by endocrine changes associated with pregnancy and lactation but not by age. The thickness of the X zone is an index of growth and maturation in nulliparous female DDD mice less than one year of age. KEY WORDS: adrenal cortex, age, DDD mouse, reproduction, X zone morphology.The adrenal cortex of most mammals consists of three zones. These zones play distinct roles in steroid hormone production [11]. The mineral corticoid of the zona glomerulosa regulates Na-K valance. The glucocorticoid of the zona fasciculata regulates multiple physiological metabolisms, and the adrenal androgen is mainly produced in the zona reticularis (exclude mice and rats [11]). In the mouse, a fourth zone, the X zone, is present in the innermost cortex of the adrenal. Masui and Tamura first described the characteristics of this zone in 1924 [12]. It was named the X zone by Howard-Miller in 1927 [8]. Many studies have shown that degeneration of this zone is induced by pregnancy and lactation [10]. Furthermore, in the absence of pregnancy, X zone degeneration is induced by the administration of androgen [6]. In male mice, degeneration of the X zone is induced by sexual maturation [3]; and regeneration of a second X zone is induced by castration of adult mice or androgen administration [4,7]. Thus, the endocrinological characteristics of these four adrenocortical zones are well known. But, little studies have been conducted on agerelated changes in the morphology of these adrenocortical zones [1].Strain differences in the morphology of X zone degeneration have been observed between A/Cam and CBA/FaCam mice [15], C57BL/6By and BALB/cBy mice [8], C57BL/ 6JJms and DDD mice [18], and A/J and SM/J mice [19,20].The main differences between strains involve the extent of vacuolation, which is an index of tissue lipid content [15,18,20,24]. Although it was recently reported that the agouti locus affects vacuolation [16,19], no statistical data were provided. As female DDD mice have a thicker and more vacuolated X zone than other strains of mice [18], we considered that the female DDD mice were suitable...

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“…The alleles of vacuolation-regulating loci other than a locus may be different between BALB/c and SM/J. The timing of the X zone vacuolation is regulated by the Ex locus on chromosome 7 [2,8]. This locus may be an early type (Ex e ) or wild type in BALB/c [2], since the X zone was fully vacuolated at 70 days of age (Fig.…”

Section: Discussionmentioning

confidence: 99%

Genetic Association of Mutation at Agouti Locus with Adrenal X Zone Morphology in BALB/c Mice

Tanaka¹,

Kuwahara

Nishijima³

et al. 2006

Exp. Anim.

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A strain difference in the time and mode of regression of the adrenal X zone in female mice

Cited by 22 publications

References 28 publications

Genetic Association between Agouti Locus and Adrenal X Zone Morphology in SM/J Mice

Genetic Association between Agouti Locus and Adrenal X Zone Morphology in SM/J Mice

A Morphometric Study of the Adrenal Cortex of the Female DDD Mouse

Genetic Association of Mutation at Agouti Locus with Adrenal X Zone Morphology in BALB/c Mice

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