A straightforward one-pot synthesis of bioactive N-aryl oxazolidin-2-ones via a highly efficient Fe₃O₄@SiO₂-supported acetate-based butylimidazolium ionic liquid nanocatalyst under metal- and solvent-free conditions

Abstract

A supported ionic liquid-based magnetic nanocatalyst has been fabricated for the formation of pharmaceutically important N-aryl oxazolidin-2-ones.

The Role of Green Solvents and Catalysts at the Future of Drug Design and of Synthesis

“…In this spirit, forming of these rings with green chemistry would be very useful. Sharma's group has therefore studied on that strategy to obtain N-aryl-oxazolidine-2-ones using magnetic nanocatalyst (Scheme 24) [58]. They have tested nanocatalyst for reusability and seen that after eight runs, the yield of the product was recorded as 80-85% which was close to the first run, 95% [58].…”

“…Sharma's group has therefore studied on that strategy to obtain N-aryl-oxazolidine-2-ones using magnetic nanocatalyst (Scheme 24) [58]. They have tested nanocatalyst for reusability and seen that after eight runs, the yield of the product was recorded as 80-85% which was close to the first run, 95% [58]. Anilin (80) and ethylene carbonate (81) were reacted by means of nanocatalyst and the reaction gave almost quantitative yield.…”

Recent Advances in the Synthesis and Ring‐Opening Transformations of 2‐Oxazolidinones

“…In 2017, Sharma and co‐workers reported a novel and straightforward approach to produce N ‐aryl 2‐oxazolidinones using Fe 3 O 4 @SiO 2 ‐supported acetate‐based butylimidazolium ionic liquid as a nanocatalyst under metal‐ and solvent‐free conditions (Scheme 33). [56] The application of heterogeneous functionalized silica‐coated magnetic nanoparticles (FSMNP) largely solved the obvious drawbacks of the conventional ionic liquid catalyst such as the generation of a large amount of waste ILs, slow diffusion of substrates due to high viscosity of ILs, product purification, and tedious energy‐consuming protocols for recycling pure ILs. Another feature of this approach is its eco‐friendliness due to the metal‐, ligand‐, and solvent‐free conditions as well as the use of non‐toxic precursors.…”

Cooperative Catalysis of Ru(III)‐Porphyrin in CO2‐Involved Synthesis of Oxazolidinones

“…It has been well known that the reactions of CO 2 with different amino compounds can produce various organic chemicals, such as urea, [13,14] bis‐substituted urea, [15] carbamates [16–18] (Scheme 1, Eq. 1–3) and oxazolidinones (i. e., cyclic urethanes), [19–25] revealing that the activation of CO 2 by alkaline amino‐compounds in cooperative combination of a suitable catalyst is of fundamental importance in CO 2 ‐involed synthesis protocols.…”