A stimulated liquid–gas phase transition nanoprobe dedicated to enhance the microwave thermoacoustic imaging contrast of breast tumors

Abstract

Microwave-induced thermoacoustic imaging (MTAI), combining the advantages of the high contrast of microwave imaging and the high resolution of ultrasonic imaging, is a potential candidate for breast tumor detection. MTAI...

Oxygen-supplied mesoporous carbon nanoparticles for enhanced photothermal/photodynamic synergetic therapy against antibiotic-resistant bacterial infections

“…PFH can dissolve oxygen gas effectively due to the strong van der Waals interactions between PFH and oxygen molecules. 37,43,44 Thus, CIL@ICG with a large specic surface area and a porous structure can serve as a good oxygen carrier to deliver oxygen aer loading with PFH. As illustrated in Fig.…”

“…35,36 In addition, PFH with a boiling point of about 57 C is prone to undergo a phase transition from liquid to gas, achieving a fast release of oxygen. 37,38 Moreover, 1 O 2 in PFH is reported to be more stable than 1 O 2 in the cellular environment or water, resulting in a long-lasting PDT effect. 39 Hence, constructing a photosensitizer carrying oxygen-saturated PFH can improve the therapeutic effect of PDT.…”

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

“…Moreover, numerous nanoparticles with excellent microwave absorbing and thermal conversion properties have been developed to improve image contrast by elevating the microwave absorption coefficient of tumor, allowing thermoacoustic imaging to more accurately delineate tumor region. 10,13 Thereby, the thermoacoustic imaging provides an alternative approach for guiding interventional surgery in real-time.…”

“…As a new imaging technique with the merits of noninvasiveness, high contrast, and high resolution, microwave-induced thermoacoustic imaging (thermoacoustic imaging for short) shows great potential in the tumor diagnosis and intraoperative navigation, which relies on the thermoelastic effect that the lossy dielectric sample absorb pulsed microwave energy and subsequently emit acoustic waves through thermal expansion. − Previous studies indicate that the changes of polar molecule and ion contents with tumor progression will result in the difference of microwave absorption between normal and tumor tissues. , The thermoacoustic images directly reflect the microwave absorption properties of tissues, enabling it to indicate the tumor region based on the subtle difference of endogenous microwave absorption medium. Moreover, numerous nanoparticles with excellent microwave absorbing and thermal conversion properties have been developed to improve image contrast by elevating the microwave absorption coefficient of tumor, allowing thermoacoustic imaging to more accurately delineate tumor region. , Thereby, the thermoacoustic imaging provides an alternative approach for guiding interventional surgery in real-time.…”

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

“…Among the exogenous contrast agents that have been reported [18] , [19] , [20] , conductance loss nanoprobe (engineered saline nanodroplet [21] ), dielectric loss nanoprobes ( e.g. rGO [22] , amino acids [23] , WS 2 [24] , etc. ), magnetic loss nanoprobes ( e.g.…”