A step closer to understanding the relationship between host and gut microbiota metabolism

Barker-Tejeda, Tomás Clive; Zubeldia‐Varela, Elisa; Obeso, David

doi:10.1111/all.15246

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Relatively low abundance of Bacteriodetes have been reported in food-allergic children [ 40 ]. The metabolomics research identified microbial metabolites and provided insight into host–microbiota interactions and disease onset [ 34 , 41 ].…”

Section: Risk Factors Of Epithelial Barrier Dysfunctionmentioning

confidence: 99%

The epithelial barrier theory: development and exacerbation of allergic and other chronic inflammatory diseases

Küçüksezer

Özdemir

Yazıcı

et al. 2023

Asia Pacific Allergy

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It is now longer than half a century, humans, animals, and nature of the world are under the influence of exposure to many newly introduced noxious substances. These exposures are nowadays pushing the borders to be considered as the causative or exacerbating factors for many chronic disorders including allergic, autoimmune/inflammatory, and metabolic diseases. The epithelial linings serve as the outermost body’s primary physical, chemical, and immunological barriers against external stimuli. The “epithelial barrier theory” hypothesizes that these diseases are aggravated by an ongoing periepithelial inflammation triggered by exposure to a wide range of epithelial barrier–damaging insults that lead to “epithelitis” and the release of alarmins. A leaky epithelial barrier enables the microbiome’s translocation from the periphery to interepithelial and even deeper subepithelial areas together with allergens, toxins, and pollutants. Thereafter, microbial dysbiosis, characterized by colonization of opportunistic pathogen bacteria and loss of the number and biodiversity of commensal bacteria take place. Local inflammation, impaired tissue regeneration, and remodeling characterize the disease. The infiltration of inflammatory cells to affected tissues shows an effort to expulse the tissue invading bacteria, allergens, toxins, and pollutants away from the deep tissues to the surface, representing the “expulsion response.” Cells that migrate to other organs from the inflammatory foci may play roles in the exacerbation of various inflammatory diseases in distant organs. The purpose of this review is to highlight and appraise recent opinions and findings on epithelial physiology and its role in the pathogenesis of chronic diseases in view of the epithelial barrier theory.

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Section: Risk Factors Of Epithelial Barrier Dysfunctionmentioning

confidence: 99%

The epithelial barrier theory: development and exacerbation of allergic and other chronic inflammatory diseases

Küçüksezer

Özdemir

Yazıcı

et al. 2023

Asia Pacific Allergy

View full text Add to dashboard Cite

show abstract

“…The intestine is an important immune-digestive organ of ruminants and is one of the habitats for a large number of microorganisms that play an important role in the energy metabolism of animals and also produce metabolites in direct contact with cells of the intestinal wall (10). The intricate relationship between metabolism and the regulation of immunity and inflammation has been increasingly highlighted in research (11)(12)(13). Inflammation is a significant concern in cattle intestines as it disrupts the normal functioning of the intestinal barrier, compromises nutrient absorption, and alters immune homeostasis in cattle (14).…”

Section: Introductionmentioning

confidence: 99%

Effect of feeding a dried distillers’ grains with solubles diet on the metabolism of the intestinal wall in Guanling crossbred cattle: a preliminary assessment

Luo,

Zhang,

et al. 2024

Front. Vet. Sci.

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Dried distillers’ grains with solubles (DDGS)-based diets are nutritious and can improve the inflammations and intestinal immunity in livestock. However, there is limited research examining the effect of feeding DDGS-based diets on changes in intestinal metabolites and related pathways in livestock. In this study, six Guanling crossbred cattle (Guizhou Guanling Yellow cattle × Simmental cattle) were selected and divided into a basal diet (BD) group and an experimental group fed with DDGS replacing 25% of the daily ration concentrates (DDGS) (n=3), respectively. Fresh jejunum (J), ileum (I) and cecum (C) tissues were collected for metabolomic analysis. Differential metabolites and metabolic pathways were explored by means of univariate and multivariate statistical analysis. In comparison to the J-BD group, 123 differential metabolites (VIP > 1, p < 0.05) were identified in the J-DDGS group, which (top 20) were mainly divided into superclasses, including lipids and lipid-like molecules, organic acids and derivatives, and organoheterocyclic compounds. Compared with the I-BD group, 47 differential metabolites were obtained in the I-DDGS group, which were mainly divided into superclasses, including lipids and lipid-like molecules and organic acids and derivatives. The C-DDGS vs. C-BD comparison revealed 88 differential metabolites, which were mainly divided into superclasses, including lipids and lipid-like molecules, organic oxygen compounds, and nucleosides. A total of 34 significant metabolic pathways were found (p < 0.05, −log(p) > 1.3). Among them, 3 significant pathways were significantly enriched in the J-DDGS group, 11 significant pathways were significantly enriched in the I-DDGS group, and 20 significant pathways were significantly enriched in the C-DDGS group. Importantly, primary bile acid biosynthesis, linoleic acid metabolism, and arachidonic acid metabolism correlated with intestinal inflammation and immunity by regulating gut microbiota, prostaglandin synthesis, and cell signaling. The data suggest that DDGS-fed cattle unregulated three metabolic pathways mentioned above and that a DDGS-based diet was able to maintain a balance of these three metabolic pathways, thus resulting in improvement of intestinal inflammation and enhanced immunity in cattle. In conclusion, the DDGS diet has the potential to improve intestinal inflammation and enhance the immunity of Guanling crossbred cattle by regulating the metabolic patterns of lipids and lipid-like molecules, organic acids and derivatives, and related metabolic pathways. These results allude to potential metabolic regulatory mechanisms of DDGS diets and also provide a theoretical basis for the application of DDGS in livestock feed.

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The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

Yazici,

Ogulur,

Pat

et al. 2023

Seminars in Immunology

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A step closer to understanding the relationship between host and gut microbiota metabolism

Cited by 3 publications

References 7 publications

The epithelial barrier theory: development and exacerbation of allergic and other chronic inflammatory diseases

The epithelial barrier theory: development and exacerbation of allergic and other chronic inflammatory diseases

Effect of feeding a dried distillers’ grains with solubles diet on the metabolism of the intestinal wall in Guanling crossbred cattle: a preliminary assessment

The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

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