A sprayable hemostat containing fibrillar collagen, bovine thrombin, and autologous plasma

Prior, J. J.; Wallace, Donald G.; Harner, Andrew; Powers, Noël

doi:10.1016/s0003-4975(99)00552-4

Cited by 37 publications

(29 citation statements)

References 10 publications

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“…[8][9][10] The variance in burst pressure between the studies is due largely to the use of different test substrates (e.g., collagen films, aorta, small intestine). Gelation time prior to pressurization, which has been shown to influence adhesive strength are not reported in these studies.…”

Section: Discussionmentioning

confidence: 99%

“…Most research efforts have focused on adhesive formulations and clinical issues. The mechanical analysis of fibrin-based biomaterials has hitherto been focused on bulk uniaxial tensile, 1,2 dynamic shear properties, [3][4][5][6][7] burst pressure, [8][9][10] and tensile and shear adhesive strength. [11][12][13] These investigations describe mechanical strength and modulus as proportional to fibrinogen concentration, and that bonding strength varies with different adherends.…”

Section: Introductionmentioning

confidence: 99%

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Failure characteristics of multiple‐component fibrin‐based adhesives

Sierra

Eberhardt

Lemons

2001

J. Biomed. Mater. Res.

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A series of analyses were performed on fibrin-based adhesives to describe their failure characteristics. Two test methods were used: uniaxial, monotonic tensile testing of the bulk material, and blister testing using fresh porcine-source skin graft as the adherend. Two fibrin concentrations, high (HFC), and low (LFC), were used to investigate the effects of the gel matrix density upon mechanical properties. In tensile tests, fibrin gels strain hardened, as functions of percent strain and of strain rate. An increase in modulus of elasticity (E) was seen with increasing strain and strain rate at both tested fibrin concentrations. Mode I failure mechanisms were predominant. Both adhesives appeared to fracture from the outer edge to the interior of the specimen at slower strain rate tests. This trend reversed as strain rate increased, becoming a classic "cup and cone" ductile fracture. Syneresis occurred at both concentrations at lower strain rates, but was more pronounced for the LFC. Ultimate tensile strength and E were greater for the HFC than for the LFC at all strain rates, decreasing with increasing strain rate. In the blister test, the failure locus changed from cohesive to adhesive as the strain rate was increased for the HFC. Failure of fibrin gels likely occurs by percolation of the pressurized saline, displacing the entrapped liquid phase of the gel in regions of relatively low moduli and strength, leading to fracture of the matrix. For LFC, the overall fracture locus remained predominantly cohesive regardless of strain rate. Burst strength and failure energy were higher for HFC than for LFC. It would appear that fibrin acts more as a viscous liquid than a rubberlike/elastic material at lower concentrations because adhesive failures had a higher burst strength and fracture energy (Gc) than did cohesive failures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Failure characteristics of multiple‐component fibrin‐based adhesives

Sierra

Eberhardt

Lemons

2001

J. Biomed. Mater. Res.

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“…The collagen induces platelet aggregation only in its fibrillar form [15,16]. The platelets adhere to the collagen fibrils, degranulate, and trigger the cascade causing their aggregation [17].…”

Section: Discussionmentioning

confidence: 99%

Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model

Spector

Perry

Konobeck³

et al. 2010

Surg Endosc

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“…MI, USA), formerly known as CoStasis/Dynastat, is a sprayable haemostat consisting of bovine microfibrillar collagen, bovine thrombin and autologous plasma. In an in vivo bleeding rabbit kidney and spleen model, CoStasis provided a faster time to haemostasis than fibrin glue but formed a weaker gel that could withstand only modest pressure [56]. Moreover, depletion of both platelets and fibrinogen in the autologous plasma prolonged time to haemostasis.…”

Section: Other Productsmentioning

confidence: 99%

Use of local pro-coagulant haemostatic agents for intra-cavity control of haemorrhage after trauma

Navarro

Brooks

2014

Eur J Trauma Emerg Surg

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Our experience, supported by other reports in the literature, suggests the use of such fibrin patches may provide an effective option in helping to control haemorrhage after trauma. However, there is a general paucity of clinical data for intra-cavity haemostatic agent use, with the majority of data being based on animal models and case reports. Further clinical evidence, ideally including comparative studies between different agents, would be beneficial in helping guide surgeon choice to the most appropriate products to use in trauma settings.

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A sprayable hemostat containing fibrillar collagen, bovine thrombin, and autologous plasma

Cited by 37 publications

References 10 publications

Failure characteristics of multiple‐component fibrin‐based adhesives

Failure characteristics of multiple‐component fibrin‐based adhesives

Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model

Use of local pro-coagulant haemostatic agents for intra-cavity control of haemorrhage after trauma

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