A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance

Doghish, Ahmed S.; Hegazy, Maghawry; Ismail, Ahmed; El-Mahdy, Hesham A.; Elsakka, Elsayed G.E.; Elkhawaga, Samy Y.; El‐Kady, M. A.; Yehia, Amr Mohamed; Abdelmaksoud, Nourhan M.; Mokhtar, Mahmoud Mohamed

doi:10.1016/j.prp.2023.154442

Cited by 8 publications

(3 citation statements)

References 208 publications

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“…Reciprocally, quercetin in combination with cisplatin and oxaliplatin could be used to overcome drug resistance in cancer cells [ 79 ]. On the other hand, quercetin increased sensitivity to cisplatin in human osteosarcoma cell line 143B by modulating the expression ratio of miR-217-Kras [ 94 ]. Also, coadministration of 2.5 μM of EGCG, genistein, and quercetin suppressed the cell proliferation of a prostate cancer cell line (CWR22Rv1) by controlling androgen receptor and NAD (P)H: quinone oxidoreductase 1 (NQO1) expression [ 93 ].…”

Section: Quercetin Particularitiesmentioning

confidence: 99%

Quercetin, a Flavonoid with Great Pharmacological Capacity

Carrillo-Martinez,

Flores-Hernández,

Salazar-Montes

et al. 2024

Molecules

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Quercetin is a flavonoid with a low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. Quercetin has a potent antioxidant capacity, being able to capture reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive chlorine species (ROC), which act as reducing agents by chelating transition-metal ions. Its structure has five functional hydroxyl groups, which work as electron donors and are responsible for capturing free radicals. In addition to its antioxidant capacity, different pharmacological properties of quercetin have been described, such as carcinostatic properties; antiviral, antihypertensive, and anti-inflammatory properties; the ability to protect low-density lipoprotein (LDL) oxidation, and the ability to inhibit angiogenesis; these are developed in this review.

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Section: Quercetin Particularitiesmentioning

confidence: 99%

Quercetin, a Flavonoid with Great Pharmacological Capacity

Carrillo-Martinez,

Flores-Hernández,

Salazar-Montes

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Reciprocally, quercetin in combination with cisplatin and oxaliplatin could be used to overcome drug resistance in cancer cells [79]. On the other hand, quercetin increased sensitivity to cisplatin in human osteosarcoma cell line 143B by modulating the expression ratio of miR-217-Kras [94]. Also, coadministration of 2.5 µM of EGCG, genistein, and quercetin suppressed the cell proliferation of a prostate cancer cell line (CWR22Rv1) by controlling androgen receptor and NAD (P)H: quinone oxidoreductase 1 (NQO1) expression [93].…”

Section: Synergistic Effect In Other Types Of Cancermentioning

confidence: 99%

Quercetin, A Flavonoid With Great Pharmacological Capacity

Carrillo-Martinez,

Flores-Hernández,

Salazar-Montes

et al. 2024

Preprint

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Quercetin is a flavonoid with a low molecular weight that belongs to the human diet's phenolic phytochemicals and non-energy constituents. Quercetin has a potent antioxidant capacity, being able to capture Reactive Oxygen Species (ROS), reactive nitro-gen species (RNS), and Reactive Chlorine Species (ROC), which act as reducing agents by chelating transition metal ions. Its structure has five functional hydroxyl groups, which work as electron donors and are responsible for capturing free radicals. In addition to its antioxidant capacity, it was described different pharmacological properties of Quercetin, such as carcinostatic properties, antiviral, antihypertensive, anti-inflammatory, protection of Low-Density Lipoprotein (LDL) oxidation, and inhibi-tion of angiogenesis are developed in this review.

show abstract

“…Reciprocally, Quercetin, in combination with cispla-tin and oxaliplatin, could be used to overcome drug resistance in cancer cells [79]. On the other hand, Quercetin increases sensi-tivity to cisplatin in human osteosarcoma cell line 143B by modulating the expression ratio of miR-217-Kras [94]. Also, co-administration of 2.5 μM of EGCG, genistein, and Quercetin suppressed the cell proliferation of a prostate cancer cell line (CWR22Rv1) by controlling androgen receptor and NAD (P)H: Quinone Oxidoreductase 1 (NQO1) expression [93].…”

Section: Synergistic Effect Against Leukemiamentioning

confidence: 99%

Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection

Salazar-Campos,

Ruiz

et al. 2024

Preprint

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In recent times, using image-based deep learning techniques has been very useful for classifying fruits. However, mango is a particular challenge because its shelf life is directly related to the degree of maturity at the time of harvest, which is determined mainly through the visual assessment of the operators when sorting them, doing it incorrectly, coupled with the blows and compressions exposed during storage and transport, trigger the deterioration in their quality, hence the importance of this operation. In this sense, the purpose of this study focuses on designing a computational model based on Deep Learning that uses a convolutional neural network (CNN) parameterized to select mangoes according to their color tone based on their maturity stage. A dataset was established from 201 labeled images, then a CNN architecture was built, obtaining a model on which 3 criteria were evaluated: the number of convolution and grouping layers, the resolution of the input images and the number of training epochs required. As a result, an input image resolution of 32 x 32 pixels was achieved, the process included a convolution layer followed by pooling that fed another layer that processed the results and ended in an output layer with 2 neurons under the One Hot Encoding representation. The model required 20 epochs to perfect its training, achieving 96.04 % accuracy in mango image selection. This study supports the potential of CNNs in quality analysis through mango color selection, even in uncertainty scenarios.

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A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance

Cited by 8 publications

References 208 publications

Quercetin, a Flavonoid with Great Pharmacological Capacity

Quercetin, a Flavonoid with Great Pharmacological Capacity

Quercetin, A Flavonoid With Great Pharmacological Capacity

Design and Parameterization of a Computational Model Based on Convolutional Neural Networks for Mango Selection

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