A spatiotemporal analysis of the left coronary artery biomechanics using fluid–structure interaction models

Fandaros, Marina; Li, Yu Yulee; Cao, Jie J

doi:10.1007/s11517-023-02791-5

Cited by 4 publications

(1 citation statement)

References 88 publications

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“…The role of biomechanics in coronary artery disease was investigated using FSI simulations to analyze patient-specific coronary biomechanics in both spatial and temporal domains [57]. A three-dimensional FSI model of the left anterior descending (LAD) coronary artery was developed, considering factors like myocardial bridging.…”

Section: Blood Flow Within Vascular Pathwaysmentioning

confidence: 99%

Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods

Syed

Khan

Toma

2023

Biology

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Using fluid-structure interaction algorithms to simulate the human circulatory system is an innovative approach that can provide valuable insights into cardiovascular dynamics. Fluid-structure interaction algorithms enable us to couple simulations of blood flow and mechanical responses of the blood vessels while taking into account interactions between fluid dynamics and structural behaviors of vessel walls, heart walls, or valves. In the context of the human circulatory system, these algorithms offer a more comprehensive representation by considering the complex interplay between blood flow and the elasticity of blood vessels. Algorithms that simulate fluid flow dynamics and the resulting forces exerted on vessel walls can capture phenomena such as wall deformation, arterial compliance, and the propagation of pressure waves throughout the cardiovascular system. These models enhance the understanding of vasculature properties in human anatomy. The utilization of fluid-structure interaction methods in combination with medical imaging can generate patient-specific models for individual patients to facilitate the process of devising treatment plans. This review evaluates current applications and implications of fluid-structure interaction algorithms with respect to the vasculature, while considering their potential role as a guidance tool for intervention procedures.

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Section: Blood Flow Within Vascular Pathwaysmentioning

confidence: 99%

Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods

Syed

Khan

Toma

2023

Biology

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In silico model of stent performance in multi-layered artery using 2-way fluid-structure interaction: Influence of boundary conditions and vessel length

Khairulin,

Kuchumov,

Silberschmidt

2024

Computer Methods and Programs in Biomedicine

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Comparative analysis of mechanical wall shear stress and hemodynamics to study the influence of asymmetry in abdominal aortic aneurysm and descending thoracic aortic aneurysm

Rehman,

Ekici

2024

Physics of Fluids

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An aneurysm's rupture is commonly associated with its maximum diameter, yet biomechanical studies emphasize the significant influence of mechanical wall shear stress (WSS) in this process. This study focuses on two models of aortic aneurysms: abdominal aortic aneurysm and descending thoracic aortic aneurysm. Five cases, comprising two for model 1 and three for model 2, are examined to explore both axisymmetric and asymmetric shapes, as patient geometry may manifest as either fusiform (axisymmetric) or saccular (asymmetric), while maintaining a consistent aneurysm diameter and adjusting the bulge shape factor to induce asymmetry. Hemodynamic factors, including WSS and wall shear stress gradient, are computed to evaluate thrombus formation and rupture risk within the aneurysms. Our results indicate the presence of recirculation zones in both the medial and transverse planes, generating vortices within the aneurysm. These vortices are more prominent in asymmetric cases compared to axisymmetric cases, leading to increased blood residence time within the aneurysm and a higher likelihood of thrombus formation. Thrombus formation can further impede blood flow, heightening the risk of embolism or ischemic events. Rupture occurs when the WSS surpasses tissue strength; thus, if the tissue strength of all aneurysms is same, our findings suggest that rupture risk varies according to asymmetry. In the transverse direction, our results demonstrate that in model 1, case 1 exhibits uniform WSS on both sides, while in case 2, WSS is higher at the posterior sides of the aneurysm sac. Conversely, in model 2, WSS is higher at the anterior side of the aneurysm. In the medial direction of the aneurysm, WSS is highest for case 5, followed by case 3, case 4, case 2, and case 1, respectively, indicating elevated WSS when the anterior bulge dominates over the posterior bulge for each model. Overall, a higher rupture risk is observed in model 2 compared to model 1 due to increased mechanical stresses.

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A spatiotemporal analysis of the left coronary artery biomechanics using fluid–structure interaction models

Cited by 4 publications

References 88 publications

Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods

Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods

In silico model of stent performance in multi-layered artery using 2-way fluid-structure interaction: Influence of boundary conditions and vessel length

Comparative analysis of mechanical wall shear stress and hemodynamics to study the influence of asymmetry in abdominal aortic aneurysm and descending thoracic aortic aneurysm

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