A smart hydrogel patch with high transparency, adhesiveness and hemostasis for all-round treatment and glucose monitoring of diabetic foot ulcers

Abstract

The treatment and management of diabetic foot ulcers (DFUs) is a pretty intractable problem for clinical nursing. Urgently, the “Black Box” status of the healing process prevents surgeons from providing...

Recent advances in novel materials and techniques for developing transparent wound dressings

“…The poly(tannic acid)-doped polypyrrole nanofibrils in the poly(acrylamide-acrylate adenine) polymer network-based transparent hydrogel accelerated hemostasis, enhanced cell-to-cell contact, prevented wound infection, facilitated collagen deposition, and stimulated angiogenesis to visibly and efficiently aid the healing of diabetic foot ulcers. 194…”

Fabrication and desired properties of conductive hydrogel dressings for wound healing

“…The use of such conductive hydrogels in wound monitoring has therefore been investigated in the literature. 155 For instance, in the study by ref. 155, conductive hydrogel prepared by the assembling of polymer networks, based on in situ formed poly(tannic acid) (PTA)-doped polypyrrole (PPy) nanofibrils in the poly(acrylamide-acrylated adenine) (P(AM-Aa)) polymer.…”

“…155 For instance, in the study by ref. 155, conductive hydrogel prepared by the assembling of polymer networks, based on in situ formed poly(tannic acid) (PTA)-doped polypyrrole (PPy) nanofibrils in the poly(acrylamide-acrylated adenine) (P(AM-Aa)) polymer. The study showed that in addition to facilitating visual monitoring of wounds, the conductive hydrogel facilitated enhanced “communication” between cells for accelerated hemostasis, while also enabling the monitoring or detection of the glucose levels on wounds.…”

Sensitive and specific detection of saccharide species based on fluorescence: update from 2016

“…The current invasive wearable blood glucose sensors cause discomfort and raise the risk of infection. As a result, noninvasive wearable point-of-care sensors are being continually developed and improved [ 76 , 77 ], yet there is still significant room for improving their accuracy, repeatability, wearability, and accessibility for end users [ 78 ]. Phenylboronic acid is a well-known saccharide cis -diol binder; however, Anslyn et al proposed an unprecedented mechanism for the interaction of o -aminomethyl phenylboric acid and sugars.…”