A Small-Cell-Predominant Variant of Primary Ki-1 (CD30)+ T-Cell Lymphoma

Kinney, Marsha C.; Collins, Robert D.; Greer, John P.; Whitlock, James A.; Sioutos, Nick; Kadin, Marshall E.

doi:10.1097/00000478-199309000-00001

Cited by 229 publications

(137 citation statements)

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“…Delsol has referred to cells with these cytologic features as "hallmark" cells, because they constitute a hallmark of ALCL (26). Although they are typically large cells, smaller cells with similar cytologic features also may be seen (28). With practice, recognition of these "hallmark" cells can greatly aid in accurate diagnosis.…”

Section: Histologic Featuresmentioning

confidence: 99%

“…Another helpful architectural feature is the tendency of malignant cells to form rosettes around blood vessels (26,28). In the small cell and lymphohistiocytic variants of ALCL, the larger cells usually will be concentrated around blood cells, a distribution highlighted by staining for CD30 or ALK.…”

Section: Histologic Featuresmentioning

confidence: 99%

“…However, other histologic variants may be seen, either alone or in sequence with the common type of ALCL. The small cell and lymphohistiocytic variants are the most common, and are particularly important because they may be misdiagnosed as either atypical inflammatory lesions or malignant lymphomas of other types (28,32). The small cell and lymphohistiocytic variants are closely related, and cases containing a mixture of these two patterns can be seen.…”

Section: Histologic Featuresmentioning

confidence: 99%

“…In the small cell variant, the predominant neoplastic cell is small with clear cytoplasm (28). The nucleus has clumped chromatin, and frequent nuclear irregularities, resembling the horseshoe shaped nuclei of classical hallmark cells.…”

Section: Histologic Featuresmentioning

confidence: 99%

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Anaplastic Large Cell Lymphoma: The Shifting Sands of Diagnostic Hematopathology

2001

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Anaplastic large cell lymphoma (ALCL) is a paradigm for the process used to define new disease entities, and provides a model that is applicable to all areas of pathology. ALCL was first recognized based on characteristic histologic features (sinusoidal invasion) and a distinctive immunophenotype (CD30؉). However, neither sinusoidal invasion nor CD30-positivity proved to be entirely specific. Subsequently, a characteristic cytogenetic abnormality was identified, the t(2;5), that led to identification of the genes involved in the translocation (NPM/ALK) and insights into the pathogenesis. Generation of monoclonal antibodies to the aberrantly expressed anaplastic large cell lymphoma kinase (ALK) such as ALK-1 can be used diagnostically, and have led to improved definition of the diagnostic entity with important clinical and prognostic implications. These studies also have clarified the relationship of ALCL to Hodgkin's disease, another lymphoid malignancy associated with CD30 expression. We have learned that the ultimate histologic spectrum of ALCL is both narrower and broader than originally believed. The small cell and lymphohistiocytic variants of ALCL are ALK-positive, and are an accepted part of the disease entity, although the neoplastic cells may appear neither large nor anaplastic. Conversely, most cases of Hodgkin's-like ALCL have proved to be more closely related to true Hodgkin's disease, and are unrelated to ALCL.

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Section: Histologic Featuresmentioning

confidence: 99%

Section: Histologic Featuresmentioning

confidence: 99%

Section: Histologic Featuresmentioning

confidence: 99%

Section: Histologic Featuresmentioning

confidence: 99%

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Anaplastic Large Cell Lymphoma: The Shifting Sands of Diagnostic Hematopathology

2001

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“…Peripheral blood involvement was usually prominent (WBC range 15-151,000 with 5-92% lymphoma cells) with rare and usually minimal involvement of the bone marrow. The most common histologic type reported was the small cell variant (9 of 12), which was previously associated with frequent bone marrow involvement and a worse prognosis [14]. CD30 expression was demonstrated in all cases but the frequency of detecting a T-cell phenotype, either by immunophenotyping or PCR analysis, was variable.…”

Section: Discussionmentioning

confidence: 95%

Pediatric ALK+ anaplastic large cell lymphoma with t(3;8)(q26.2;q24) translocation and c‐myc rearrangement terminating in a leukemic phase

et al. 2006

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Pediatric ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) is usually associated with a favorable prognosis. ALK+ ALCL associated with a leukemic phase is uncommon, but has been associated with an aggressive clinical course and unfavorable prognosis. Overexpression of c-myc has been shown to be a consistent finding in ALK+, but not ALK-negative ALCL (ALKÀ ALCL), and the c-myc gene is considered a downstream target of deregulated ALK signaling. We describe a pediatric ALK+ ALCL with a leukemic phase at relapse. Similar to other rare cases described in the literature, it followed an aggressive clinical course despite multiple regimens of chemotherapy and bone marrow transplantation. Lymphoma cells showed aberrant ALK expression and c-myc overexpression. In addition to the characteristic t(2;5)(p23;q35) translocation, a t(3;8)(q26.2;q24) translocation was also present, and c-myc

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