Lymphomatoid Papulosis

Abstract

To analyze clinicopathologic features of lymphomatoid papulosis and delineate the characteristics of histopathologic variants (types A, B, and C).

A Case of Lymphomatoid Papulosis Limited to Becker's Melanosis

“…In the WHO-EORTC classification of cutaneous lymphomas it is classified in the spectrum of CD30+ cutaneous lymphoproliferative diseases [11]. Histological subclassification discriminates between type A, B and C with distinct clinical and histological features [1]. Usually LyP manifests with generalized erythematous papules and nodules that may ulcerate and spontaneously resolve after several weeks to months, often leaving atrophic scars.…”

“…It shows male predominance and may occur in all age groups [12]. Regional LyP accounts for 2-27% of all LyP cases, although reporting bias may lead to falsely high numbers and lack of a clear definition of ‘regional' does not facilitate analysis of the reported cases [1,13,14]. Regional LyP typically presents unilaterally on the trunk or extremities.…”

“…Lymphomatoid papulosis (LyP) is a CD30+ cutaneous lymphoproliferative disease clinically defined by chronically relapsing erythematous papules or nodules that may ulcerate and spontaneously regress, eventually leaving scars [1]. Becker's melanosis (BM) is characterized by regional hypermelanosis and hypertrichosis, typically located in the shoulder region [2].…”

Functions and Uses of Immunohistochemical Stains in Cutaneous Infiltrates of Hematopoietic Origin: A Review for the Practicing Dermatologist

“…Benign B-cell pseudolymphomas, in contrast, have a larger percentage of B cells, and B-cell lymphomas usually contain relatively few CD3-positive cells except in some variants, such as T cell-rich B-cell lymphoma. [8][9][10][11] Mycosis fungoides (MF) and other T-cell lymphomas may demonstrate a decrease in CD3 expression as well as other T-cell markers, especially in later-stage lesions when evaluated with flow cytometry, although CD3 is generally diffusely expressed by immunohistochemistry in virtually all stages ( Figure 3). [11][12][13][14] In contrast to some T-cell markers, diminished CD3 expression has been shown to be nonspecific.…”

“…Type B specimens tend to be negative. 10,63 CD30 also stains the Reed-Sternberg cells in virtually 100% of classic Hodgkin lymphoma and is more sensitive for these cells than CD15. 41 Less than 25% of patients with MF will undergo transformation, where the malignant cells become larger and more numerous, the tumor extent becomes more diffuse, epidermotropism is decreased, and the clinical course is much more aggressive.…”