A Slightly Low Hemoglobin Level Is Beneficially Associated with Arterial Stiffness in Japanese Community-Dwelling Women

Kawamoto, Ryuichi; Tabara, Yasuharu; Kohara, Katsuhiko; Miki, Tetsuro; Kusunoki, Tomo; Katoh, Tateaki; Ohtsuka, Nobuyuki; Takayama, Shuzo; Abe, Masanori

doi:10.3109/10641963.2011.618202

Cited by 47 publications

(50 citation statements)

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“…These mechanisms may then explain the positive association between the hemoglobin levels and hypertension, especially in patients with atherosclerosis. A Japanese study of 120 men and 223 women reported that slightly low hemoglobin levels had a beneficial effect on arterial stiffness in community-dwelling women but not men (5). That study partly supports the concept that higher hemoglobin levels indicate the presence of both hypertension and atherosclerosis.…”

Section: Discussionsupporting

confidence: 72%

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Association between the Hemoglobin Levels and Hypertension in Relation to the BMI Status in a Rural Japanese Population: The Nagasaki Islands Study

et al. 2014

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Objective The hemoglobin levels and blood pressure has been reported in a few studies, and a positive association between the hemoglobin levels and the body mass index (BMI) status has also been documented. A higher BMI may therefore affect the association between the hemoglobin levels and hypertension. However, no published studies have examined this association in relation to the BMI status. The primary purpose of this study was to assess the association between the hemoglobin levels and hypertension in relation to the BMI status. Methods A cross-sectional study of 3,203 non-anemic subjects (1,191 men and 2,012 women, 30-79 years old) who were undergoing general health checkups was conducted. Results A positive association between the hemoglobin levels and hypertension was established for both men and women. For a one SD (standard deviation) increment in hemoglobin, the multivariable odds ratio (ORs) and 95% confidence interval (CIs) for hypertension were 1.21 (95%CI: 1.05-1.40) for men and 1.25 (95%CI: 1.13-1.39) for women. We also found that a significant association was confined to the participants with a BMI of <25 kg/m 2 . Among the participants with a BMI of <25 kg/m 2 , the multivariable ORs and 95% CIs for hypertension of a one SD increment in hemoglobin were 1.34 (95%CI: 1.12-1.60) for men and 1.31 (95%CI: 1.16-1.47) for women. Meanwhile, among those with a BMI of ! 25 kg/m 2 , the corresponding values were 1.01 (95%CI: 0.79-1.30) and 1.09 (95%CI: 0.87-1.37). Conclusion An independent positive association between the hemoglobin levels and the risk of hypertension was observed for both non-anemic Japanese men and women, confined to participants with a BMI of <25 kg/m 2 .

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Section: Discussionsupporting

confidence: 72%

“…Previous studies have found a positive association between the hemoglobin levels and blood pressure (4,5). Another study reported that treatment with erythropoiesisstimulating proteins used to treat anemia in hemodialysis patients is related to elevated blood pressure (6).…”

Section: Introductionmentioning

confidence: 99%

Association between the Hemoglobin Levels and Hypertension in Relation to the BMI Status in a Rural Japanese Population: The Nagasaki Islands Study

et al. 2014

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“…It has been reported that Hb is strongly related to arterial stiffness, as measured by pulse wave velocity, which, in turn, increases SBP and DBP. 6 Furthermore, free Hb may be a scavenger of NO. NO, produced in the endothelial cells that line the blood vessels, relaxes the muscle cells surroundings the vessel and thereby controls blood pressure.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 In previous research among hemodialysis patients, the administration of erythropoietin, an erythropoiesis-stimulating protein used for the treatment of anemia, was related to an elevated blood pressure. 7,8 Moreover, in patients with orthostatic hypotension, increasing the red cell volume by erythropoietin elevated blood pressure while standing.…”

mentioning

confidence: 99%

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Atsma

Veldhuizen²,

Kort³

et al. 2012

Hypertension

123

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Abstract-It has been hypothesized that an increased hemoglobin level elevates blood pressure. The present study investigated the association between hemoglobin level and systolic blood pressure and diastolic blood pressure in healthy persons. The study population was composed of 101 377 whole blood and plasma donors, who made 691 107 visits to the blood bank. At each visit, hemoglobin level and blood pressure were measured as part of the standard procedure before a blood donation. We used repeated measurement analysis to analyze the data. We used generalized estimating equation models to assess the between-person effect and linear mixed models to assess the within-person effect. All of the analyses were done separately for men and women. In the study population, 50% were men. The mean age in men was 49.3 years (±12.5 years), and in women it was 42.4 years (±13.7 years). Hemoglobin level was positively associated with both systolic and diastolic blood pressures. With respect to the between-person effect, regression coefficients for systolic blood pressure were 1.3 mm Hg per millimole per liter increase in hemoglobin level for men and 1.8 mm Hg per millimole per liter increase in hemoglobin level for women. With respect to the within-person effect, regression coefficients for systolic blood pressure were 0.7 mm Hg and 0.9 mm Hg per millimole per liter increase in hemoglobin level, for men and women, respectively. For diastolic blood pressure, results were comparable. The results show that hemoglobin level is positively associated with both systolic and diastolic blood pressures in healthy individuals. We observed consistent effects between persons but also within persons.

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“…A linear stepwise regression analysis examining the variables significantly associated with PWV at the time of study termination revealed several factors associated with baPWV. The association with hemoglobin was unexpected and further study is needed to characterize this result (23,24).…”

Section: Discussionmentioning

confidence: 99%

Changes in Ankle Brachial Pulse Wave Velocity during a Five-Year Follow-up Period in Older Japanese Adults: Sub-analysis Results of the Health Research Volunteer Study in Japan

et al. 2013

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Objective Brachial-ankle pulse wave velocity (baPWV) is a measure of arterial stiffness. However, precisely how aging, hypertension and other factors influence this in progressively stiffening large arteries, especially in older adults, remains uncertain. We examined changes in arterial stiffness in a population of active older Japanese adults using a five-year follow-up cohort study. Methods Comprehensive geriatric assessments were performed in socially active adults over the age of 70 years at The Life Planning Center Clinic in Tokyo. Clinically acceptable baPWV measurements at baseline and at the end of the study were obtained in 257 individuals (115 men, baseline mean age of 78±4 years; 142 women, baseline mean age of 77±4 years) classified into four groups based on the use of antihypertensive interventions at the end of the study: Group 1 (112 normotensives), Group 2 (49 hypertensives without medication use), Group 3 (39 hypertensives with medication use initiated during the follow-up period) and Group 4 (57 hypertensives receiving medications throughout the follow-up period). Results During the follow-up period, Group 1 exhibited no changes in blood pressure with increases in baPWV. Group 2 exhibited increases in blood pressure and baPWV. Both Groups 3 and 4 exhibited decreases in blood pressure without any changes in baPWV. Other factors such as age, gender and the hemoglobin level could also have influenced baPWV. Conclusion Arterial stiffness increases with aging; however, antihypertensive medications were found to provide protective effects against the development of arterial stiffness during a five-year follow-up period. Other factors that modify baPWV were also identified.

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A Slightly Low Hemoglobin Level Is Beneficially Associated with Arterial Stiffness in Japanese Community-Dwelling Women

Cited by 47 publications

References 36 publications

Association between the Hemoglobin Levels and Hypertension in Relation to the BMI Status in a Rural Japanese Population: The Nagasaki Islands Study

Association between the Hemoglobin Levels and Hypertension in Relation to the BMI Status in a Rural Japanese Population: The Nagasaki Islands Study

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Changes in Ankle Brachial Pulse Wave Velocity during a Five-Year Follow-up Period in Older Japanese Adults: Sub-analysis Results of the Health Research Volunteer Study in Japan

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