“… 79 , 80 , 81 , 82 , 83 Developmental sleep is regulated by the conserved clock Period gene 82 and is promoted by the RIS neuron. 84 , 85 , 86 , 87 Disruption of APTF-1 or LIM-6, transcription factors required to specify the RIS neuron, results in decreased sleep. 88 , 89 , 90 Sleep in C. elegans has also been shown to coincide with synaptic plasticity 91 and recent work has defined the neuronal and synaptic changes that link experience and sleep to memory-related behavior.…”