Abstract:Sleep is a vital behavioral and physiological state. It is controlled by conserved genes and neuronal circuit mechanisms. In the round worm Caenorhabditis elegans, one single neuron called RIS is essential for sleep. During sleep, RIS activates to shut down behavior and to support survival. Here, we summarize how stress leads to the activation of RIS signaling through immunity and longevity signaling pathways and how the single RIS neuron becomes crucial for the round worm to survive.
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.