A Six‐Month Comparison of Three Periodontal Local Antimicrobial Therapies in Persistent Periodontal Pockets

Kinane, Denis F.; Radvar, Mehrdad

doi:10.1902/jop.1999.70.1.1

Cited by 95 publications

(94 citation statements)

References 32 publications

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“…An elevated antibody response to A. actinomycetemcomitans has been reported to function to eliminate the bacteria. 38) A. actinomycetemcomitans may be eliminated by a high level of antibody to A. actinomycetemcomitans in ACS. Subsequently, A. actinomycetemcomitans could not be detected in the chronic period.…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

et al. 2007

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SUMMARYRecent epidemiological studies suggest that periodontitis is an important risk factor for coronary heart disease (CHD). The aim of this study was to evaluate the association between periodontitis and CHD, particularly acute coronary syndrome (ACS), focusing on microbiological and immunological features.Twenty-eight CHD patients, 15 with ACS and 13 with chronic CHD, were included in this study. Coronary angiography, periodontal examination, and dental radiography were performed in all patients. Subgingival plaque, saliva, and blood samples were analyzed for the periodontopathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia using polymerase chain reaction.Specific serum antibody titers to the 5 periodontal pathogens were determined by enzyme-linked immunosorbent assay. It was found that 33% of the ACS patients (5/15) harbored A. actinomycetemcomitans in oral samples, whereas no A. actinomycetemcomitans (0/13) was found in the chronic CHD patients (P < 0.05). Furthermore, ACS patients showed significantly higher serum IgG titers to A. actinomycetemcomitans (P < 0.05) compared with chronic CHD. More tooth loss and alveolar bone loss were noted in ACS patients than in chronic CHD patients, although the differences were not statistically significant.Periodontal pathogens, particularly A. actinomycetemcomitans, may play a role in the development of ACS. (Int Heart J 2007; 48: 663-675)

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Section: Discussionmentioning

confidence: 99%

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

et al. 2007

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“…[12][13][14]21 Although the use of systemic antibiotics has been studied in patients with GAgP, the use of adjunctive TCF in these patients has not been reported. 1,22,23 The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with generalized aggressive periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis

Purucker

Mertes

Goodson³

et al. 2001

Journal of Periodontology

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“…Quiryen et al suggested that CHX treatment should be re-evaluated as an adjunct to SRP periodontal therapy (Quiryen et al, 2000). While the use of antibiotics (e.g., minocycline and tetracycline) represents a possible adjunct to SRP, and local drug delivery systems can improve clinical and microbial outcomes (Williams et al, 2001), their systemic use has undesirable side effects (e.g., antibiotic resistance, pseudomembranous colitis) (Radvar et al, 1996;Kinane and Radvar, 1999). The development of alternative treatments for periodontitis thus remains an important area of current oral health care research.…”

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confidence: 99%

Antibacterial Efficacy of Exogenous Nitric Oxide on Periodontal Pathogens

Backlund¹,

Sergesketter²,

Offenbacher

et al. 2014

J Dent Res

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Current treatments for periodontitis (e.g., scaling/ root planing and chlorhexidine) have limited efficacy since they fail to suppress microbial biofilms satisfactorily over time, and the use of adjunctive antimicrobials can promote the emergence of antibiotic-resistant organisms. Herein, we report the novel application of nitric oxide (NO)-releasing scaffolds (i.e., dendrimers and silica particles) as anti-periodontopathogenic agents. The effectiveness of macromolecular NO release was demonstrated by a 3-log reduction in periodontopathogenic Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis viability. In contrast, Streptococcus mutans and Streptococcus sanguinis, caries-associated organisms, were substantially less sensitive to NO treatment. Both dendrimerand silica-based NO release exhibited substantially less toxicity to human gingival fibroblasts at concentrations necessary to eradicate periodontopathogens than did clinical concentrations of chlorhexidine. These results suggest the potential utility of macromolecular NO-release scaffolds as a novel platform for the development of periodontal disease therapeutics.

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A Six‐Month Comparison of Three Periodontal Local Antimicrobial Therapies in Persistent Periodontal Pockets

Abstract: Although all 3 locally applied antimicrobial systems seem to offer some benefit over scaling and root planing alone, a treatment regimen of scaling and root planing plus tetracycline fiber placement gave the greatest reduction in probing depth over the 6 months after treatment.

Cited by 95 publications

References 32 publications

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

High Incidence of Actinobacillus Actinomycetemcomitans Infection in Acute Coronary Syndrome

Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis

Antibacterial Efficacy of Exogenous Nitric Oxide on Periodontal Pathogens

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