Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis

Purucker, Peter; Mertes, Helmut; Goodson, J. Max; Bernimoulin, Jean‐Pierre

doi:10.1902/jop.2000.72.9.1241

Cited by 46 publications

(50 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, no significant difference was found between systemic and local administrations of the drugs when combined with SRP, indicating the stronger effect of mechanical periodontal treatment on clinical healing. To date, 4 studies have compared the efficacy of local drug delivery and administration of systemic antibiotics (56)(57)(58)(59). In one of these studies, no significant difference was found between treatments with respect to probing depth reduction and increase of clinical attachment (58).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, others found that there was no difference in clinical results when application of local metronidazole was compared to systemic metronidazole (56). Purucker et al (59) have compared the clinical effects of systemic amoxicillin/clavulanic acid treatment versus local tetracycline therapy 3 months after SRP treatment and concluded that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid produced similar clinical outcomes. However, similar to our findings, in another study local metronidazole provided better results than systemic metronidazole with regard to bone deposition when assessed by subtraction radiography (57).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

et al. 2004

View full text Add to dashboard Cite

In this study, the clinical efficacies of systemic doxycycline (SD) and local doxycycline (LD) in the treatment of chronic periodontitis were compared. Forty-five patients were studied in 3 main groups with 5 treatments: SD alone, SD+scaling-root planing (SD+SRP), LD alone, LD+SRP and SRP alone. Antibiotic-treated patients were given doxycycline treatment alone in 1 quadrant of their upper jaws, and doxycycline+SRP was given in the contralateral quadrant. The areas included at least 4 teeth with ≥ 5 mm pockets. Probing depth (PD), clinical attachment level, gingival index, sulcular bleeding index and plaque index values were recorded at baseline and the 7 th week. The results were statistically analyzed. All of the clinical parameters were significantly reduced by all treatments (P ≤ 0.05). The SD and LD treatments alone provided significant clinical healings. The significant differences among the groups were only in PD at the 7th week. The LD treatment provided significantly higher PD reduction than the SD treatment (P ≤ 0.05). No significant difference was found between the SD+SRP and the LD+SRP treatments. There was no significant difference between SD+SRP and SRP alone treatment (P > 0.05). The SD group showed lower PD reduction than SRP group (P ≤ 0.05), while no significant difference was found between LD and SRP treatments. The LD alone treatment seemed more effective than SD alone treatment on PD reduction, but no significant difference was found between them when combined with the SRP. LD may be more preferable than SD as an adjunct to mechanical treatment since LD seems more effective than SD on PD reduction and does not have the side effects of SD. (J. Oral Sci. 46, [25][26][27][28][29][30][31][32][33][34][35] 2004) Key Words: tetracycline; systemic doxycycline; local doxycycline; periodontal treatment; local drug delivery; chronic periodontitis. IntroductionCurrently, periodontal disease is accepted as an infection of the periodontium since the primary etiologic factor is bacteria, which triggers the host immune response and the consequent tissue destruction. Because of its infectious nature, in a biological view, the main target for periodontal treatment must be the suppression of the effective bacteria (1,2). In light of this conceptual development, it recently has been considered that mechanical treatment alone is insufficient in the periodontal treatment strategy. Antimicrobial therapy, especially antibiotic treatment, is of special importance as an adjunct to mechanical periodontal treatment (1,3,4).To date, the most widely used antibiotics in the treatment of periodontal disease have been tetracyclines since they show the highest concentrations in gingival crevicular fluid (GCF) and are highly effective on Actinobacillus Actinomycetemcomitans (Aa) (5,6). Recently, some nonJournal of Oral Science, Vol. 46, No. 1, 25-35, 2004 7,8). In one of the studies, patients with moderate chronic periodontitis were administered doxycycline for 2 weeks prior to a full-thickness flap procedur...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Adjunctive use of LDD agents like controlled release biodegradable chlorhexidine gluconate chip [61, 62], tetracycline fibers [63, 64], and minocycline-Hcl gel [65] has been tried in aggressive periodontitis with superior clinical outcomes. The decision to use local anti-infective adjunctive therapy remains a matter of individual clinical judgment, the phase of treatment, and the patient's status and preferences.…”

Section: Discussionmentioning

confidence: 99%

Generalized Aggressive Periodontitis and Its Treatment Options: Case Reports and Review of the Literature

Roshna

Nandakumar

2012

Case Reports in Medicine

View full text Add to dashboard Cite

Generalized aggressive periodontitis results in rapid destruction of the periodontium and can lead to early tooth loss in the affected individuals if not diagnosed early and treated appropriately. The diagnostic features of the disease are characteristic, but the clinical presentation and patterns of destructions may vary between patients. Successful management of the disease is challenging especially if diagnosed at advanced stages of the disease, but not impossible with the current therapeutic choices for the disease. A vast array of treatment modalities is available which can be employed in the treatment of generalized aggressive periodontitis with varying success rates, but a definite guideline for the management is yet to be formulated. However, with the exponential rate of developments in periodontal research, regenerative therapy, tissue engineering, and genetic technologies, the future seems promising in regard to options at managing the disease. This paper attempts to describe the clinical and radiographic diagnostic features and the current treatment options along with a suggested protocol for comprehensive management of generalized aggressive periodontitis patients with case reports and a brief review.

show abstract

“…The use of local delivery of antimicrobial agents to the management of localized aggressive periodontitis is effective when does not respond adequately to mechanical and systemic antibiotic therapy. Adjunctive use of local drugs delivery agents like controlled release biodegradable chlorhexidine gluconate chip, tetracycline fibers and minocycline-HCl gel has been tried in aggressive periodontitis with superior clinical outcomes [69][70][71][72][73] .…”

Section: Serial and Combination Therapymentioning

confidence: 99%

Management of Rapidly Progressing Periodontitis: An Overview

Sadat¹,

Chowdhury

Baten³

2017

Med. Today

View full text Add to dashboard Cite

History of periodontal diseases recognition and treatment is ancient for at least 5000 years. There are different presentations of periodontal diseases. Rapidly progression periodontitis or aggressive periodontitis causes rapid destruction of the periodontium which leads to early tooth loss. It may be generalized or localized. Periodontitis may be treated surgically or non-surgically but patients with rapidly progressing periodontitis do not respond predictably to conventional therapy due to its multi factorial etiology. Successful management of the disease is difficult if not diagnosed early and treated appropriately. Regenerative therapy, tissue engineering and genetic technologies are the new hope for the treatment of rapidly progressing periodontitis.Medicine Today 2016 Vol.28(1): 32-38

show abstract

Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis

Abstract: These results indicate that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid given 3 months after scaling and root planing produced similar clinical outcomes over the 9-month observation period.

Cited by 46 publications

References 29 publications

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

Generalized Aggressive Periodontitis and Its Treatment Options: Case Reports and Review of the Literature

Management of Rapidly Progressing Periodontitis: An Overview

Contact Info

Product

Resources

About