A Singular Case of Graves’ Disease in Congenital Thyroid Hemiagenesis

Baldini, Marina; Orsatti, A.

doi:10.1159/000084568

Cited by 14 publications

(8 citation statements)

References 62 publications

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“…To our knowledge 16 cases of Graves’ disease in association with thyroid hemiagenesis have previously been reported worldwide 4 9–23. This is the first case reported from the UK.…”

Section: Discussionmentioning

confidence: 81%

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A UK reported case of Graves’ disease with thyroid hemiagenesis

Faulkner¹,

Varadharajan

Choudhury

2019

BMJ Case Rep

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We present a rare case of a 31-year-old patient with Graves’ disease with agenesis of the left thyroid lobe. The patient was managed with a right hemithyroidectomy and isthmusectomy as definitively treatment of Graves’ disease. The patient had an uneventful postoperative outcome and the histology was benign and consistent with Graves’ disease. This is a rare case in the literature of Graves’ disease with unilateral thyroid agenesis, and to our knowledge is the first reported case from the UK.

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“…To our knowledge 16 cases of Graves’ disease in association with thyroid hemiagenesis have previously been reported worldwide 4 9–23. This is the first case reported from the UK.…”

Section: Discussionmentioning

confidence: 81%

“…In those patients undergoing surgery, two cases also failed to control thyroid function with medical therapy and one underwent thyroidectomy for an associated thyroid malignancy. All cases had successful treatment outcomes 4 9–23…”

Section: Discussionmentioning

confidence: 97%

A UK reported case of Graves’ disease with thyroid hemiagenesis

Faulkner¹,

Varadharajan

Choudhury

2019

BMJ Case Rep

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“…Various pathologies reported are multinodular goitre, Grave's disease, Hashimoto's thyroiditis, papillary thyroid cancer and primary hyperparathyroidism [8,9]. Incidence of thyroid neoplasms is higher in these set of patients both as a result of higher TSH levels and due to higher incidence of nodules in them.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Hemiagenesis: Role of an Oncologist

Vd¹,

Nair²,

Datta³

et al. 2015

JCR

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Abstract:Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of thyroid fails to develop; which may or may not be associated with failure of development of the isthmus. Most of the patients remain asymptomatic. Thyroid pathologies are more common in these patients than the normal population. Euthyroid cases without any above mentioned disorders need reassurance for the patient. Importance of this case lies in two important things. First thyroid hemiagenesis is associated with increased incidence of other associated disorders including malignancy. Hence close follow up is essential. Secondly, when in euthyroid status, proper patient counselling and avoidance of unnecessary surgery are of paramount importance to avoid permanent hypothyroidism.

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“…However, in other individuals, the single thyroid lobe was reduced in size [2]. In an unusual case of Graves' disease, thyroid hemiagenesis was observed [4]. Individuals with thyroid hemiagenesis tended to develop other thyroid abnormalities but no common genetic basis was found for this condition [3].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hemiagenesis in a Thyroiditis Prone Mouse Strain

et al. 2018

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Background: Thyroid hemiagenesis, a rare congenital condition detected by ultrasound screening of the neck, is usually not manifested clinically in humans. This condition has been reported in mice with hypothyroidism associated with induced deficiency in paired box 8 and NK2 homeobox 1, sonic hedgehog, or T-box 1. Unexpectedly, we observed thyroid hemiagenesis in NOD.H2^h4 mice, an unusual strain that spontaneously develops iodide enhanced thyroid autoimmunity but remains euthyroid. Objectives and Methods: First, to compare mice with thyroid hemiagenesis versus bilobed littermates for serum T4, autoantibodies to thyroglobulin (ELISA) and thyroid peroxidase (TPO; flow cytometry with eukaryotic cells expressing mouse TPO), gross anatomy, and thyroid histology; second, to estimate the percentage of mice with thyroid hemiagenesis in the NOD.H2^h4 mice we have studied over 6 years. Results: Thyroid hemiagenesis was observed in 3 of 1,025 NOD.H2^h4 mice (2 females, 1 male; 0.3%). Two instances of hemiagenesis were in wild-type females and one in a transgenic male expressing the human TSHR A-subunit in the thyroid. Two mice had very large unilobed glands, as in some human cases with this condition. Thyroid lymphocytic infiltration, serum T4, and the levels of thyroid autoantibodies were similar in mice with thyroid hemiagenesis and bilobed littermates. Conclusions: Unlike hypothyroidism associated with hemiagenesis in transcription factor knockout mice, hemiagenesis in euthyroid NOD.H2^h4 mice occurs spontaneously and is phenotypically similar to that occasionally observed in humans.

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A Singular Case of Graves’ Disease in Congenital Thyroid Hemiagenesis

Cited by 14 publications

References 62 publications

A UK reported case of Graves’ disease with thyroid hemiagenesis

A UK reported case of Graves’ disease with thyroid hemiagenesis

Thyroid Hemiagenesis: Role of an Oncologist

Thyroid Hemiagenesis in a Thyroiditis Prone Mouse Strain

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