A singly charged ion source for radioactive 11C ion acceleration

Katagiri, Ken; Noda, Akira; Nagatsu, Koutarou; Nakao, Masao; Hojo, Satoru; Muramatsu, M.; Suzuki, Kazutoshi; Wakui, Takashi; Noda, K.

doi:10.1063/1.4935899

Cited by 12 publications

(47 citation statements)

References 4 publications

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“…The idea is to build a small cyclotron that can produce low-energy RIBs with an ISOL system (86), and these ions are then injected in conventional synchrotrons. A source using low-energy electron beams for the production of 11 C has been designed and produced at HIMAC (87). Within the MEDICIS-Promed project (88), CERN has proposed a charge breeding scheme based on an Electron Beam Ion Source for beam preparation of a radioactive 11 C beam (89).…”

Section: Discussionmentioning

confidence: 99%

Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Boscolo¹,

Kostyleva²,

Safari³

et al. 2021

Front. Oncol.

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Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Boscolo¹,

Kostyleva²,

Safari³

et al. 2021

Front. Oncol.

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“…The idea is to build a small cyclotron that can produce low-energy RIB with an ISOL system, and these ions are then injected in conventional synchrotrons. A source using low-energy electron beams for the production of 11 C has been designed and produced at HIMAC [85]. Within the MEDICIS-Promed project [86], CERN has proposed a charge breeding scheme based on an Electron Beam Ion Source for beam preparation of a radioactive 11 C beam [87].…”

Section: Rib Productionmentioning

confidence: 99%

Radioactive Beams in Particle Therapy: Past, Present, and Future

Durante

Parodi

2020

Front. Phys.

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Heavy ion therapy can deliver high doses with high precision. However, image guidance is needed to reduce range uncertainty. Radioactive ions are potentially ideal projectiles for radiotherapy because their decay can be used to visualize the beam. Positron-emitting ions that can be visualized with PET imaging were already studied for therapy application during the pilot therapy project at the Lawrence Berkeley Laboratory, and later within the EULIMA EU project, the GSI therapy trial in Germany, MEDICIS at CERN, and at HIMAC in Japan. The results show that radioactive ion beams provide a large improvement in image quality and signal-to-noise ratio compared to stable ions. The main hindrance toward a clinical use of radioactive ions is their challenging production and the low intensities of the beams. New research projects are ongoing in Europe and Japan to assess the advantages of radioactive ion beams for therapy, to develop new detectors, and to build sources of radioactive ions for medical synchrotrons.

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“…The advantage of using PET-isotopes such as 11 C for external beam radiation therapy has been subject of many discussions and studies. Pioneer work was performed at the Bevalac at the Lawrence Berkeley Laboratory, where the utilization of Radioactive Ion Beams (RIBs) for hadron therapy was originally proposed and examined [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Pioneer work was performed at the Bevalac at the Lawrence Berkeley Laboratory, where the utilization of Radioactive Ion Beams (RIBs) for hadron therapy was originally proposed and examined [1][2][3]. The exploitation of 11 C as a therapeutic beam has re-gained increased attention after pilot-studies at NIRS, Chiba, where low-intensity 11 C beams have been produced by projectile fragmentation for pre-clinical imaging studies [4,5]. Since 11 C is a β + -emitter (half-life, T 1/2 = 20.4 min), therapy can be combined with online PET-imaging techniques when using it for hadron therapy, thereby enabling in vivo range verification of the therapeutic RIB.…”

Section: Introductionmentioning

confidence: 99%