A single session of physical activity restores the mitochondrial organization disrupted by obesity in skeletal muscle fibers

Rivera-Álvarez, Irais; Pérez-Treviño, Perla; Chapoy‐Villanueva, Héctor; Vela-Guajardo, Jorge E.; Nieblas, Bianca; Garza-González, Salvador; García‐Rivas, Gerardo; Garcı́a, Noemı́

doi:10.1016/j.lfs.2020.117965

Cited by 3 publications

(2 citation statements)

References 79 publications

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“…6 and Supplementary table 4). Other pathways were related to mitochondrial organization and protein localization in these organelles, confirming an observed relationship with physical exercise 66 . It is worth pointing out that while most of the studies investigated the effect of physical activity on miRNA expression measured after exercise, our samples were collected randomly during the day.…”

Section: Discussionsupporting

confidence: 70%

Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals

Francavilla

Gagliardi

Piaggeschi

et al. 2021

Sci Rep

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For their stability and detectability faecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers. However, there is no evidence on how stool miRNA profiles change according to an individual’s age, sex, and body mass index (BMI) or how lifestyle habits influence the expression levels of these molecules. We explored the relationship between the stool miRNA levels and common traits (sex, age, BMI, and menopausal status) or lifestyle habits (physical activity, smoking status, coffee, and alcohol consumption) as derived by a self-reported questionnaire, using small RNA-sequencing data of samples from 335 healthy subjects. We detected 151 differentially expressed miRNAs associated with one variable and 52 associated with at least two. Differences in miR-638 levels were associated with age, sex, BMI, and smoking status. The highest number of differentially expressed miRNAs was associated with BMI (n = 92) and smoking status (n = 84), with several miRNAs shared between them. Functional enrichment analyses revealed the involvement of the miRNA target genes in pathways coherent with the analysed variables. Our findings suggest that miRNA profiles in stool may reflect common traits and lifestyle habits and should be considered in relation to disease and association studies based on faecal miRNA expression.

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Section: Discussionsupporting

confidence: 70%

Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals

Francavilla

Gagliardi

Piaggeschi

et al. 2021

Sci Rep

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show abstract

“…In addition, recent evidence suggests that the improved quality of mitochondria, alongside with increase in quantity, may also be a key factor in protecting the heart from CVD [ 67 , 90 , 91 , 92 ]. Mitochondrial quality is usually measured with O 2 consumption, membrane integrity and morphology, which can all be enhanced by regular exercise [ 93 , 94 , 95 , 96 , 97 , 98 ]. A 2019 study found that mitophagy, more than macroautophagy, is critical in maintaining cardiac function in diabetic cardiomyopathy [ 99 ].…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Molecular Mechanisms of Exercise and Healthspan

Guan

Yan

2022

Cells

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Healthspan is the period of our life without major debilitating diseases. In the modern world where unhealthy lifestyle choices and chronic diseases taper the healthspan, which lead to an enormous economic burden, finding ways to promote healthspan becomes a pressing goal of the scientific community. Exercise, one of humanity’s most ancient and effective lifestyle interventions, appears to be at the center of the solution since it can both treat and prevent the occurrence of many chronic diseases. Here, we will review the current evidence and opinions about regular exercise promoting healthspan through enhancing the functionality of our organ systems and preventing diseases.

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The physiological benefits of sitting less and moving more: Opportunities for future research

Hwang¹,

Chen²,

Chou³

et al. 2022

Progress in Cardiovascular Diseases

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A single session of physical activity restores the mitochondrial organization disrupted by obesity in skeletal muscle fibers

Cited by 3 publications

References 79 publications

Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals

Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals

Molecular Mechanisms of Exercise and Healthspan

The physiological benefits of sitting less and moving more: Opportunities for future research

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