A single run, rapid polarity switching method for determination of 30 pharmaceuticals and personal care products in waste water using Q-Exactive Orbitrap high resolution accurate mass spectrometry

Abstract

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Occurrence and risk assessment of selected pharmaceuticals in water and sediments of Usuma Dam, Abuja, Nigeria

“…However, only Trimethoprim was detected in this study. Similar occurrence has been reported in river samples in Egypt and South Africa where Sulfamethoxazole was not detected and Trimethoprim was detected at 230 ng/L and 0.14 µg/L respectively [62,64].…”

“…Amoxycillin was detected at 10% frequency in the water samples at concentration of 659.02 ng/L. Amoxycillin concentration in the water samples was higher than the reported concentration in Tanzanian water [61] and Egyptian water [62] but lower than the concentration reported in Chinese Pearl River [63]. A recent study in Nigeria reported an average Amoxycillin concentration of 13,300 ng/L in Lagos surface water [15].…”

Overview of Sample Preparation and Chromatographic Methods to Analysis Pharmaceutical Active Compounds in Waters Matrices

“…Abdallah et al [206] show the UPLC-Q Exactive TM Orbitrap MS's capability for simultaneous determination of 28 acidic and basic PhACs in a single run using rapid polarity switching of the electrospray ionisation source. The PhACs belong to seven therapeutical classes, such as antibiotics, antiseptics, beta-blockers, NSAIDs, narcotic analgesics, anti-hyperglycemic, and proton-pump inhibitors.…”

Detection of pharmaceuticals in wastewater effluents—a comparison of the performance of Chemcatcher® and polar organic compound integrative sampler

“…targeted and untargeted analyses) for the presence or absence of a wide range of pollutants. Such analyses rely on the use of high-resolution accurate mass systems including, time-of-flight (TOF), quadrupole time-offlight (Q-TOF) and Orbitrap instruments (Rimayi et al 2019;Pinasseau et al 2019;Abdallah et al 2019). The use of high-resolution mass spectrometry is essential in order to obtain data on molecular ions, isotope patterns and fragment ions from the highly complex extracts, which contain numerous substances many of which will have similar molecular masses.…”