A Single Exposure to GSM-1800 MHz Signals in the Course of an Acute Neuroinflammatory Reaction can Alter Neuronal Responses and Microglial Morphology in the Rat Primary Auditory Cortex

The effects of radio-frequency radiation (RFR) exposure on the analgesic efficacy of morphine in healthy rats and rats with inflammation

“…In this study, it was shown that RFR exposure has an inhibitory effect on pain. Similar results were obtained by Ozdemir et al [26] who indicated that the application of the extremely low frequency EMF to rats increased the morphine analgesia and reduced morphine analgesic tolerance . These results might be caused by changes in the underlying neurophysiological processes, as suggested by Bailey and Connor [27].…”

Effects of a Single Head Exposure to GSM-1800 MHz Signals on the Transcriptome Profile in the Rat Cerebral Cortex: Enhanced Gene Responses Under Proinflammatory Conditions

“…In keeping with this hypothesis, we previously found (Lameth et al 2017) that in LPS-treated rats, a same head exposure to GSM 1800 MHz impacted on glutamate-mediated excitatory neurotransmission, as indicated by a reduced phosphorylation of serine residues (Ser 845 and 831) in the gluA1 subunit of cortical AMPAR, which are known to affect the conductance of AMPAR channel and synaptic plasticity. Alterations in excitatory (glutamate-mediated) neurotransmission were further documented by electrophysiological recording in the primary auditory cortex, showing GSM-induced reduction in spontaneous and sound-evoked firing rate (Occelli et al 2018). Our current study strongly suggests that the reduced phosphorylation of gluA1 subunit implicates GSM-induced upregulation of protein phosphatase 3 (also called calcineurin).…”

“…As in previous studies (Lameth et al 2017;Occelli et al 2018), adult male rats were exposed head only to GSM-1800 MHz for 2 h and the exposure was performed 24 h after the LPS injection. Based on previous evidence of gene responses in the dorso-medial region of the cerebral cortex (Lameth et al 2017), we focused our investigation on an area of this brain region in which SAR values were maximal, making the assumption that local gene responses increase with local SAR values.…”

“…This pathological condition is mimicked in rodents by lipopolysaccharide (LPS) injection (Dantzer 2001;Hoogland et al 2015). Investigating brain cell responses triggered by RF in LPS-treated rats, we previously reported that a single 2-h head-only exposure to GSM-1800 MHz led to alterations in the neuroinflammatory process (Lameth et al 2017;Occelli et al 2018). These alterations involved modifications in the morphologies of proinflammatory effector cells such as microglia and reduced expression of the interleukin-1ß (Il1ß) gene.…”

“…The effect could be detected as late as 24 h after the GSM exposure in the dorsomedial cerebral cortex where the average SAR value was estimated as 2.94 W/kg. GSM signals also impacted on the evoked activity of cortical neurons and neurotransmission, as indicated by the reduction of action potential emission evoked by sounds in the auditory cortex (Occelli et al 2018) and by reduced phosphorylation of glutamatergic ionotropic alpha-amino-3-hydroxy-5 methyl-4-isoxazole propionic acid receptors (AMPARs) (Lameth et al 2017). Importantly, these GSM-1800 MHz cell responses were not observed in the brain of healthy rats that were submitted to the same head-only exposure, indicating that the brain cell response to GSM signals was promoted by the LPS-induced neuroinflammation.…”