A Single Dose of Oral ATP Supplementation Improves Performance and Physiological Response During Lower Body Resistance Exercise in Recreational Resistance-Trained Males

Abstract

The aim of this study was to investigate the acute effect of ATP supplementation on performance and physiological responses during resistance exercise in recreationally resistance trained males. Eleven men (age= 27.5±5.5 yrs, weight= 83.4±9.8 kg, height= 182±0.04 cm) completed two randomized, double-blind trials: ATP supplement condition (ATP=400mg) or a placebo condition. Thirty minutes after supplement consumption, subjects performed four sets of half-squats until momentary muscular failure at 80% of the 1RM with two minutes of recovery between sets. The total number of repetitions, blood pressure, heart rate, blood lactate, and oxygen consumption were evaluated. The total weight lifted were higher for the ATP condition compared to placebo (Placebo= 3995.7±1137.8, ATP= 4967.4±1497.9 Kg; p= 0.005). Heart rate was higher at set-4 for ATP compared to placebo (p<0.001) and oxygen consumption during exercise was greater for ATP (p=0.021). There were no differences between conditions for lactate and blood pressure. In summary, a single oral dose of ATP supplementation improved lower body resistance training performance and energy expenditure in recreational resistance trained males.

Oral adenosine 5′-triphosphate supplementation improved hemodynamic and autonomic parameters after exercise in hypertensive women

“…The investigation about the influence of ATP supplementation on exercise performance is widely explored in the literature, demonstrating ergogenic effects ( Freitas et al, 2017 ; Purpura et al, 2017 ; Wilson et al, 2013 ). Recently, our group investigated the acute influences of ATP supplementation on performance during resistance exercise (4 sets until muscular failure with 80% of one-repetition maximum in squat exercise) and physiological response in trained men.…”

“…Recently, our group investigated the acute influences of ATP supplementation on performance during resistance exercise (4 sets until muscular failure with 80% of one-repetition maximum in squat exercise) and physiological response in trained men. The results showed higher performance, oxygen consumption and energy expenditure with ATP supplementation compared with placebo ( Freitas et al, 2017 ), however, the effect of acute ATP supplementation on blood pressure and autonomic modulation after exercise is unknown at the literature.…”

“…Supplementation or placebo was ingested 30 min before exercise supplied in identical bottles. To ensure double-blind design, we chose this specific juice (Clight) as placebo due to flavor similarity with ATP supplement ( Freitas et al, 2017 ).…”

“…It has been investigated the influence of oral adenosine-5’-triphosphate (ATP) supplementation on resistance exercise performance, demonstrating ergogenic effects ( Freitas et al, 2017 ; Purpura et al, 2017 ; Wilson et al, 2013 ). The great interest of ATP supplementation can be associated with physiological effects of extracellular ATP on skeletal muscle excitability and vascular tissue.…”

Sports nutrition: science and practical application in relation to improvement of performance and preservation of the health of athletes. IOC Consensus Statement

“…С целью значительного уменьшения частоты побочных явлений золотым стандартом и «нутриентом выбора» могут быть метаболические и метаболитотропные субстанции, к которым, например, относятся L-карнитин и L-аргинин, янтарная кислота и ее производные, АТФ в виде защищенных от гидролиза форм и др. [23,26,43,45,62,63], а также средства на основе лекарственных растений [53]. Следует добавить, что ценность применения в практике подготовки спортсменов вышеперечисленных веществ, имеющих опосредованное или прямое действие при интенсивных физических нагрузках, в течение 2015-2016 гг.…”