A single center 14 years study of infectious complications leading to hospitalization of patients with primary antibody deficiencies

Abstract

We declare no confl ict of interest. ABSTRACTPrimary antibody deficiencies (PADs) are a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to bacterial infections, leading to hospitalizations. This study was performed to determine the main infectious causes of hospital admissions in selective Iranian patients with PADs. Forty patients with PADs, who were admitted to the Infectious Ward of Children's Medical Center Hospital during a 14-year period, were reviewed in this study. There were 115 documented episodes of hospital admission during a 14-year period. The average length of hospital stay was 33.30 ± 25.72 days. Pneumonia was the most prominent infection leading to hospitalization among these patients (n = 48), followed by gastroenteritis (n = 23). Other less frequent causes of hospitalization were fever and neutropenia, septic arthritis, encephalitis, orbital cellulitis, sepsis, urinary tract infection, meningitis, oral ulcer, and lung abscess. The most common causative organisms of diarrhea were: Giardia lamblia, followed by Candida albicans, and Salmonella sp. Many patients with PADs suffer from repeated infections leading to hospitalization, in spite of immunoglobulin replacement therapy. Respiratory tract infections were the prominent cause of hospitalization among studied patients, followed by gastrointestinal infections.

Approach to the Management of Autoimmunity in Primary Immunodeficiency

“…According to the result of different PID registries in the world, IgAD represents the most common PAD, followed by CVID . Hypogammaglobulinemia is the major hallmark of patients with PAD and present with a clinical phenotype including chronic and recurrent infections, chronic inflammation and autoimmunity [particularly haematologic abnormalities, autoimmune thyroiditis (AIT), autoimmune nephritis, inflammatory bowel disease (IBD) and RA], leading to recurrent hospitalization and a decrease in the patients’ quality of life .…”

Die bronchopulmonale Salmonellose - eine Fallserie und Literaturübersicht

“…2). Hierzu zählen ein Lebensalter über 50 Jahre [5,10,11], Autoimmunerkrankungen wie systemischer Lupus erythematodes [12] oder die granulomatöse Polyangiitis [13], die eine immunsuppressive Therapie, einschließlich einer systemischen Dauertherapie mit Kortikosteroiden, erfordern, eine chemotherapeutische Behandlung, insbesondere mit Substanzen, die ein hohes Mucositis-Risiko bergen [14,15], eine HIV-Infektion [16,17], ein Antikörpermangelsyndrom [18], Alkoholismus [19,20], hämatologische Neoplasien und solide Malignome [21,22] sowie eine Dauertherapie mit Antazida [20,23]. Zudem besteht ein erhöhtes Risiko für extraintestinale fokale Salmonellosen durch die Subspezies II bis IV bei durch Reptilien und Amphibien übertragenen Salmonellosen [24].…”

Pesquisas em pneumologia recentemente publicadas em revistas brasileiras

“…Mamishi et al (49) determined the most common infectious causes of hospital admissions in select Iranian patients with primary antibody deficiencies. The authors found that respiratory tract infections were the most common cause of hospitalization among those patients.…”