A simplified automated procedure for generation of human lymphokine-activated killer cells for use in clinical trials

Aebersold, Paul C.; Carter, Charles S.; Hyatt, Cornelia; Johnson, Susan E.; Ottaway, Katherine; Leitman, Susan F.; Rosenberg, Steven A.

doi:10.1016/0022-1759(88)90025-7

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Cell Separation and Enrichment For T Cells1

Introduction1

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Cited by 13 publications

(2 citation statements)

References 5 publications

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“…Peripheral blood mononuclear ceUs (PBMC) from ttie leukapheresis collections will be separated from the red cells and neuttophils by Ficoll-Hypaque density gradient centiifugation according to previously pubUshed techniques (45)(46)(47)(48)(49). The PBMC will then be washed and counted.…”

Section: Cell Separation and Enrichment For T Cellsmentioning

confidence: 99%

Gene Therapy for AIDS Using Retroviral Mediated Gene Transfer to Deliver HIV-1 Antisense TAR and Transdominant Rev Protein Genes to Syngeneic Lymphocytes in HIV-1 Infected Identical Twins. National Institutes of Health, Bethesda, Maryland

Morgan¹,

Walker²

1996

Human Gene Therapy

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Section: Cell Separation and Enrichment For T Cellsmentioning

confidence: 99%

Gene Therapy for AIDS Using Retroviral Mediated Gene Transfer to Deliver HIV-1 Antisense TAR and Transdominant Rev Protein Genes to Syngeneic Lymphocytes in HIV-1 Infected Identical Twins. National Institutes of Health, Bethesda, Maryland

Morgan¹,

Walker²

1996

Human Gene Therapy

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“…In China, cancer immunotherapy with T cells has been widely used in the clinic. As early as 1988, a modality referred to as lymphokine-activated killer cells 11 was applied to tumor treatment. Starting in the late 1990s, another T cell-based immunotherapy called cytokine-induced killer (CIK) therapy 12 gradually became a more popular modality.…”

Section: Introductionmentioning

confidence: 99%

Clinical development of CAR T cell therapy in China: 2020 update

et al. 2020

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Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in the treatment of hematological malignancies. In recent years, fast-growing CAR T clinical trials have actively explored their potential application scenarios. According to the data from the clinicaltrials.gov website, China became the country with the most registered CAR T trials in September 2017. As of June 30, 2020, the number of registered CAR T trials in China has reached 357. In addition, as many as 150 other CAR T trials have been registered on ChiCTR. Although CAR T therapy is flourishing in China, there are still some problems that cannot be ignored. In this review, we aim to systematically summarize the clinical practice of CAR T-cell therapy in China. This review will provide an informative reference for colleagues in the field, and a better understanding of the history and current situation will help us more reasonably conduct research and promote cooperation.

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Clinical Trials of Immunotherapy of Cancer Utilizing Cytotoxic Cells

Ettinghausen¹,

Rosenberg²

1993

Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

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A simplified automated procedure for generation of human lymphokine-activated killer cells for use in clinical trials

Cited by 13 publications

References 5 publications

Gene Therapy for AIDS Using Retroviral Mediated Gene Transfer to Deliver HIV-1 Antisense TAR and Transdominant Rev Protein Genes to Syngeneic Lymphocytes in HIV-1 Infected Identical Twins. National Institutes of Health, Bethesda, Maryland

Gene Therapy for AIDS Using Retroviral Mediated Gene Transfer to Deliver HIV-1 Antisense TAR and Transdominant Rev Protein Genes to Syngeneic Lymphocytes in HIV-1 Infected Identical Twins. National Institutes of Health, Bethesda, Maryland

Clinical development of CAR T cell therapy in China: 2020 update

Clinical Trials of Immunotherapy of Cancer Utilizing Cytotoxic Cells

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