A Simple Synthesis of Dibenzo[b,g][1,8]naphthyridines.

Sampathkumar, Natarajan; Kumar, Nikhil; Rajendran, S. P.

doi:10.1002/chin.200442171

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Damage to the outer membrane of gramnegative cells leads to the release of lipopolysaccharides, lipids, phospholipids, divalent cations necessary for lipopolysaccharide stability, and periplasniic enzymes that may disrupt membrane permeability (22, 73,168). Permeability control is also lost at low temperatures because of decreased membrane fluidity (63,113), and alterations in permeability have also been associated with chlorination (206) and alkalinity (177). Changes in permeability have led to the suggestion that certain treatments, such as heating, freezing, drying, and radiation, create small pores in the outer membrane (114).…”

Section: Stress-induced Cellular Modification and Injurymentioning

confidence: 99%

Stress, Sublethal Injury, Resuscitation, and Virulence of Bacterial Foodborne Pathogens

Wesche

Gurtler

Marks

et al. 2009

Journal of Food Protection

412

261

View full text Add to dashboard Cite

Environmental stress and food preservation methods (e.g., heating, chilling, acidity, and alkalinity) are known to induce adaptive responses within the bacterial cell. Microorganisms that survive a given stress often gain resistance to that stress or other stresses via cross-protection. The physiological state of a bacterium is an important consideration when studying its response to food preservation techniques. This article reviews the various definitions of injury and stress, sublethal injury of bacteria, stresses that cause this injury, stress adaptation, cellular repair and response mechanisms, the role of reactive oxygen species in bacterial injury and resuscitation, and the potential for cross-protection and enhanced virulence as a result of various stress conditions.

show abstract

Section: Stress-induced Cellular Modification and Injurymentioning

confidence: 99%

Stress, Sublethal Injury, Resuscitation, and Virulence of Bacterial Foodborne Pathogens

Wesche

Gurtler

Marks

et al. 2009

Journal of Food Protection

412

261

View full text Add to dashboard Cite

show abstract

“…We reasoned that benzoyl esters of the prodrug enhance their cellular uptake, retention, and target carboxylesterase enzymes simultaneously. 27 We used the azido group at the reducing end to initiate copper(I) aided azide-alkyne click chemistry to build αor β-isomers of 4-deoxy-4-fluoro-2,3-dibenzoyl xylose azide (prodrug) and their corresponding hydrophilic, debenzoylated 4-deoxy-4-fluoro-xyloside (drug) library (see Supporting Information for experimental details). Copper(I) catalyzed azide-alkyne click chemistry afforded 1,4-disubstituted triazole rings on the reducing end of the sugar with a hydrophobic aglycon group on carbon-4.…”

Section: Synthesis Of 4-deoxy-4-fluoro-xylose-derived Inhibitorsmentioning

confidence: 99%

Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In contrast to ManNAc analogs, Sia analogs with large N-acyl substituents can be effectively metabolized into cell surface glycoconjugates. 208,[211][212][213] To further investigate this concept, Yarema and coworkers varied the size of the protecting group and measured the resulting changes in metabolic conversion and cell toxicity Figure 25 The sialic acid biosynthetic pathway. In fact, phosphorylation of ManNAc by ManNAc-6-kinase has been identified as the bottleneck in metabolism of N-acyl-substituted ManNAc analogs.…”

Section: Metabolic Flux Of Unnatural Sugar Analogs and Effects On Celmentioning

confidence: 99%