A simple strategy to fabricate poly (acrylamide-co-alginate)/gold nanocomposites for inactivation of bacteria

Zhang, Yanan; Lou, Zhichao; Zhang, Xiaohong; Hu, Xiaodan; Zhang, Haiqian

doi:10.1007/s00339-014-8610-1

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Carbohydrate functionalization/stabilization of AuNPs makes them multivalent systems, thus facilitating their interactions with proteins like lectins . There are different pathways to produce poly(acrylamide) composites with AuNPs (i) by polymerizing acrylamide along with a cross-linker and then synthesizing AuNPs or (ii) by reacting HAuCl 4 with poly(acrylamide) under basic pH. , However, the synthesis of nanocomposites through the latter pathway is the least explored. Incidentally, Tatarchuka et al reported the reaction of HAuCl 4 with acrylamide in water to yield a colloidal solution of AuNPs, stable for few days …”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Glycobis(acrylamide)-Stabilized Gold Nanoparticles for Fluorescent Turn-on Sensing of Lectin and Escherichia coli

Ajish¹,

Kanagare²,

Kumar³

et al. 2019

ACS Appl. Nano Mater.

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Gold nanoparticles (AuNPs) with shelf lives of more than 6 months at 25 °C were synthesized by in situ reduction and stabilization using a D-glucose-based bis(acrylamide) solution. Transmission electron microscopy (TEM) images support the homogeneous coating of AuNPs by Glc-bis. In the process, intrinsic emission of self-assembled glycobis(acrylamide) (Glc-bis) was quenched by AuNPs, and the resultant system, Glc-bis@AuNPs, can work as a turn-on sensor, wherein the quenched emission was restored upon the addition of lectin, Concanavalin A (Con A). The aggregation of Glc-bis@AuNPs upon interaction with Con A was pragmatic from the TEM images. The quenching as well as recovery of the emission based on the proximity of AuNPs with Glc-bis in Glc-bis@AuNPs was further confirmed by steady-state as well as fluorescence lifetime measurements. The Glc-bis@AuNPs system was found to be stable up to 1 M NaCl concentration, a factor that fulfills the requirement for biosensing applications. The binding constant of Glc-bis@AuNPs toward Con A was 9.8 × 10 4 M −1 , while the limit of detection was 1.6 nM. The interaction of Glc-bis@ AuNPs with a FimH-positive, pathogenic K12 strain of Escherichia coli resulted in restoration of the emission, but experiments with the FimH-negative TOP10 strain did not yield any emission.

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Section: Introductionmentioning

confidence: 99%

Self-Assembled Glycobis(acrylamide)-Stabilized Gold Nanoparticles for Fluorescent Turn-on Sensing of Lectin and Escherichia coli

Ajish¹,

Kanagare²,

Kumar³

et al. 2019

ACS Appl. Nano Mater.

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Polysaccharides

Ogundare

Zyl

2021

Reducing Agents in Colloidal Nanoparticle Synthesis

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The diverse natural abundance of polysaccharides provides a rich source for the green synthesis of colloidal nanoparticles (NPs) at a relatively cheap cost and at a sustainable level. This chapter describes polysaccharides as reducing agents in the synthesis of colloidal NPs. It is pertinent to note that polysaccharides act not only as reducing agents but also as stabilizing and structural directing agents under suitable reaction conditions. These roles are strongly influenced by the chemical composition and the sequence of ordering of the repeating units into macromolecules, as well as the molecular weight. Ionic polysaccharides show an improved stabilizing effect, but the reducing capacity is limited to an increase in the number of ionic functionality and is sensitive to the tuning of reaction conditions to stimulate electron transfer. This chapter also highlights the potential applications of the synthesized colloidal NPs in medicine, catalysis and sensing. The contributions of polysaccharides to these applications are significant, as they provide biocompatibility and large surface area for interaction of the NPs. Looking to the future, polysaccharides are a potential game changer in the synthesis of green colloidal NPs once reaction conditions are optimized toward obtaining NPs with uniform size and morphology with a substantial market value.

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Advanced Hydrogels Combined with Silver and Gold Nanoparticles against Antimicrobial Resistance

et al. 2023

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The development of multidrug-resistant (MDR) microorganisms has increased dramatically in the last decade as a natural consequence of the misuse and overuse of antimicrobials. The World Health Organization (WHO) recognizes that this is one of the top ten global public health threats facing humanity today, demanding urgent multisectoral action. The UK government foresees that bacterial antimicrobial resistance (AMR) could kill 10 million people per year by 2050 worldwide. In this sense, metallic nanoparticles (NPs) have emerged as promising alternatives due to their outstanding antibacterial and antibiofilm properties. The efficient delivery of the NPs is also a matter of concern, and recent studies have demonstrated that hydrogels present an excellent ability to perform this task. The porous hydrogel structure with a high-water retention capability is a convenient host for the incorporation of the metallic nanoparticles, providing an efficient path to deliver the NPs properly reducing bacterial infections caused by MDR pathogenic microorganisms. This article reviews the most recent investigations on the characteristics, applications, advantages, and limitations of hydrogels combined with metallic NPs for treating MDR bacteria. The mechanisms of action and the antibiofilm activity of the NPs incorporated into hydrogels are also described. Finally, this contribution intends to fill some gaps in nanomedicine and serve as a guide for the development of advanced medical products.

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A simple strategy to fabricate poly (acrylamide-co-alginate)/gold nanocomposites for inactivation of bacteria

Cited by 3 publications

References 42 publications

Self-Assembled Glycobis(acrylamide)-Stabilized Gold Nanoparticles for Fluorescent Turn-on Sensing of Lectin and Escherichia coli

Self-Assembled Glycobis(acrylamide)-Stabilized Gold Nanoparticles for Fluorescent Turn-on Sensing of Lectin and Escherichia coli

Polysaccharides

Advanced Hydrogels Combined with Silver and Gold Nanoparticles against Antimicrobial Resistance

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