2019
DOI: 10.1556/1326.2018.00354
|View full text |Cite
|
Sign up to set email alerts
|

A simple stability-indicating HPLC method for simultaneous analysis of paracetamol and caffeine and its application to determinations in fixed-dose combination tablet dosage form

Abstract: A simple, economic, rapid, reliable, and stability-indicating high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of paracetamol (PCM) and caffeine (CF) in solid dosage form. The chromatographic separations were achieved with a Waters Symmetry W C18 column (5 μm, 4.6 × 150 mm), using a mixture of methanol and water (40:60, v/v) as a mobile phase, under isocratic elution mode with a flow rate of 0.8 mL/min, and ultraviolet (UV) detection was s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
12
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
5
1
1

Relationship

0
7

Authors

Journals

citations
Cited by 22 publications
(13 citation statements)
references
References 20 publications
1
12
0
Order By: Relevance
“…(2) Assay . The content of paracetamol in each of the eighteen batches was determined using a reverse-phase chromatographic technique developed and validated in [ 28 ] with some modifications. Twenty paracetamol tablets were randomly sampled and weighed accurately and the average weight was recorded.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…(2) Assay . The content of paracetamol in each of the eighteen batches was determined using a reverse-phase chromatographic technique developed and validated in [ 28 ] with some modifications. Twenty paracetamol tablets were randomly sampled and weighed accurately and the average weight was recorded.…”
Section: Methodsmentioning
confidence: 99%
“…e physicomechanical properties of formulated tablets such as weight, dimensions, friability, crushing strength, and disintegration times were assessed using Pharmacopoeia methods [22,26,27] (2) Assay. e content of paracetamol in each of the eighteen batches was determined using a reverse-phase chromatographic technique developed and validated in [28] with some modifications. Twenty paracetamol tablets were randomly sampled and weighed accurately and the average weight was recorded.…”
Section: Evaluation Of Tablet Propertiesmentioning
confidence: 99%
“…To reduce the gastrointestinal side effects, NASIDs are frequently treated as a mixture form with proton pump inhibitors such as omeprazole, esomeprazole, and pantoprazole [7][8][9]. In addition, for the enhancement of the drug potency, NSAIDs have been treated with caffeine as a fixed-dose combination [10,11]. Therefore, there are growing researches on the simultaneous analysis of the mixture forms regarding NSAIDs [1][2][3][4][5][6].…”
Section: Introductionmentioning
confidence: 99%
“…As the use of multi-component drugs increases in medicine, there is a need for a quantitative method to analyze the components in a drug mixture accurately [1][2][3][4][5]. Chromatography, a method that separates a mixture of ingredients based on their molecular structure and composition, has been widely used for protein purification and antibody separation [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…The chemical structures are shown in Figure 1. Tablets with a fixed-dose combination of NSAIDs with caffeine are more effective than the individual NSAIDs [2,3]. Also, NSAID mixtures with gastric ulcer reducers, such as omeprazole, esomeprazole, and pantoprazole acting as proton pump inhibitors, are broadly used to reduce the gastric side effect of NSAIDs [1,4,5].…”
Section: Introductionmentioning
confidence: 99%