A simple procedure for the isolation of human secretory IgA of IgA1 and IgA2 subclass by a jackfruit lectin, jacalin, affinity chromatography

Kondoh, Hozumi; Kobayashi, Kunihiko; Hagiwara, Keiji

doi:10.1016/0161-5890(87)90169-6

Cited by 64 publications

(8 citation statements)

References 9 publications

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“…67,87 Jacalin is nonimmunogenic, and its affinity towards the ubiquitously oncologically expressed T-antigen makes it an exciting targeting moiety. Jacalin has, however, been shown to bind to carbohydrate moieties on IgA antibodies, 88,89 which may limit its use as a targeting ligand.…”

Section: Protein Directed Gold Nanoparticlesmentioning

confidence: 99%

Active targeting of gold nanoparticles as cancer therapeutics

et al. 2020

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Section: Protein Directed Gold Nanoparticlesmentioning

confidence: 99%

Active targeting of gold nanoparticles as cancer therapeutics

et al. 2020

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“…Through EDC-NHS coupling, Jacalin was conjugated to the AuNPs using a PEG ligand, similar to the method utilized in conjugating the antibodies with AuNPs mentioned in the above section. , By utilizing Jacalin, enhanced internalization and a high level of cancer cell death were observed in cells with high expression of T antigen, but for nonconjugated AuNPs, almost no cytotoxic activity was observed. , Therefore, Jacalin demonstrated a significant affinity for T-antigen-expressing cancer cells and, more importantly, was nonimmunogenic. However, due to its significant affinity, it also demonstrated a certain affinity for the carbohydrate moieties on IgA antibodies, which may restrict its usage as a targeting ligand. ,, …”

Section: Enhanced Permeability and Retention Effectmentioning

confidence: 99%

“…However, due to its significant affinity, it also demonstrated a certain affinity for the carbohydrate moieties on IgA antibodies, which may restrict its usage as a targeting ligand. 127,190,191 Peptide-Conjugated AuNPs. The comparatively brief amino acid polymers known as peptides can be thoroughly specified and chemically modified to a specific specification.…”

Section: ■ Introductionmentioning

confidence: 99%

Surface Functionalization of Gold Nanoparticles for Targeting the Tumor Microenvironment to Improve Antitumor Efficiency

Tan

Kumar

2023

ACS Appl. Bio Mater.

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Gold nanoparticles (AuNPs) have undergone significant research for their use in the treatment of cancer. Numerous researchers have established their potent antitumor properties, which have greatly impacted the treatment of cancer. AuNPs have been used in four primary anticancer treatment modalities, namely radiation, photothermal therapy, photodynamic therapy, and chemotherapy. However, the ability of AuNPs to destroy cancer is lacking and can even harm healthy cells without the right direction to transport them to the tumor microenvironment. Consequently, a suitable targeting technique is needed. Based on the distinct features of the human tumor microenvironment, this review discusses four different targeting strategies that target the four key features of the tumor microenvironment, including abnormal vasculature, overexpression of specific receptors, an acidic microenvironment, and a hypoxic microenvironment, to direct surface-functionalized AuNPs to the tumor microenvironment and increase antitumor efficacies. In addition, some current completed or ongoing clinical trials of AuNPs will also be discussed below to further reinforce the concept of using AuNPs in anticancer therapy.

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“…Our first study in this field involved Jacalin. This Gal/GalNAc-binding lectin is able to selectively bind to human IgA1 through recognition of the O-glycan core, which is repeatedly found in the hinge region of the α1 heavy chain [50, 51]. …”

Section: Artinm As An Immunomodulatory Lectinmentioning

confidence: 99%

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

et al. 2013

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Advances in the glycobiology and immunology fields have provided many insights into the role of carbohydrate-protein interactions in the immune system. We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response to certain pathological conditions, such as cancer and infections. The present review comprises four main themes: (1) an overview of plant lectins that exert immunomodulatory effects and the mechanisms accounting for these activities; (2) general characteristics of the immunomodulatory lectin ArtinM from the seeds of Artocarpus heterophyllus; (3) activation of innate immunity cells by ArtinM and consequent induction of Th1 immunity; (4) resistance conferred by ArtinM administration in infections with intracellular pathogens, such as Leishmania (Leishmania) major, Leishmania (Leishmania) amazonensis, and Paracoccidioides brasiliensis. We believe that this review will be a valuable resource for more studies in this relatively neglected area of research, which has the potential to reveal carbohydrate targets for novel prophylactic and therapeutic strategies.

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A simple procedure for the isolation of human secretory IgA of IgA1 and IgA2 subclass by a jackfruit lectin, jacalin, affinity chromatography

Cited by 64 publications

References 9 publications

Active targeting of gold nanoparticles as cancer therapeutics

Active targeting of gold nanoparticles as cancer therapeutics

Surface Functionalization of Gold Nanoparticles for Targeting the Tumor Microenvironment to Improve Antitumor Efficiency

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

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