A simple preparation of N-doped reduced graphene oxide as an electrode material for the detection of hydrogen peroxide and glucose

Gaidukevič, Justina; Aukštakojytė, Rūta; Kozłowski, Mieczysław; Barkauskas, Jurgis; Pauliukaitė, Rasa

doi:10.1016/j.electacta.2023.142113

Cited by 11 publications

(3 citation statements)

References 72 publications

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“…After 16 days of storage, the current response maintains 89% of the initial current. The reason for the reduction of current response during long-term stability could be due to the leaching of AuNPs/NPC from the GCE surface during the washing process of the electrodes and hindering of the active sites by adsorbed analytes or intermediate species . Additionally, the operational stability of AuNPs/NPC/GCE was examined by continuously determining the H 2 O 2 concentration for 3000 s. And the result shows that the current response remains at 89% after 3000 s, showing acceptable operational stability (Figure a).…”

Section: Resultsmentioning

confidence: 99%

Nanozyme Sensor Based on Au Nanoparticles/N-Doped Porous Carbon Composites for Biosensing

Chen,

Zhang,

Liu

et al. 2024

ACS Appl. Nano Mater.

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The rational construction of nanomaterials with boosted peroxidase (POD)-like activity is momentous in artificial enzyme design and biological catalytic fields. Herein, a hybrid nanozyme, gold nanoparticles/N-doped porous carbon (AuNPs/ NPC), is fabricated via a supramolecular assembly-assisted pyrolysis strategy and engineered as a peroxidase mimic. In this strategy, a melamine-cyanurate supramolecular aggregate can be employed not only as a self-vanishing template to gain porous morphology but also as a nitrogen source to achieve an exceptional high N doping. The obtained NPC is then subsequently used to immobilize AuNPs via an in situ reduction approach. Benefiting from well-dispersed ultrafine AuNPs, high N content, hierarchical porous architecture, and the synergistic effect of AuNPs and NPC, the fabricated nanozyme exhibits enhanced POD-like activity, making it a potential alternative to peroxidase mimics. Besides, the AuNPs/NPC shows highly electrocatalytic properties, which could serve as a signal amplification platform for ultrasensitively detecting hydrogen peroxide (H 2 O 2 ). The hybrid nanozyme-based electrochemical sensor shows a linear relationship within 0.2− 7000 μM. Significantly, the sensitivity and limit of detection of the fabricated sensor are 285.9 μA mM −1 cm −2 and 67 nM, respectively. Also, this biosensor is applied to detect H 2 O 2 in human serum samples and A549 cells with desirable results. Therefore, the present work offers a facile strategy for the fabrication of a high N-contained hybrid nanozyme to simulate the catalytic activity of natural enzymes and exhibits broad prospects in biosensing, mimicking-enzyme catalytic fields, and clinical diagnosis.

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Section: Resultsmentioning

confidence: 99%

Nanozyme Sensor Based on Au Nanoparticles/N-Doped Porous Carbon Composites for Biosensing

Chen,

Zhang,

Liu

et al. 2024

ACS Appl. Nano Mater.

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“…Furthermore, "N" has a higher electronegativity (3.04) than "C" (2.55). Moreover, "N" can form strong bonds with "C" atoms [38,39]. In this way, a more stable structure can form [40].…”

Section: Introductionmentioning

confidence: 99%

“…In this way, a more stable structure can form [40]. N doping in graphene not only enhances charge carrier mobility, but also makes it more hydrophilic as well as generating more active sites [38]. Additionally, N doping can remarkably improve the conductivity [41] and can enhance the biocompatibility of graphene [42].…”

Section: Introductionmentioning

confidence: 99%

N-Doped Graphene and Its Derivatives as Resistive Gas Sensors: An Overview

et al. 2023

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Today, resistance gas sensors which are mainly realized from metal oxides are among the most used sensing devices. However, generally, their sensing temperature is high and other materials with a lower operating temperature can be an alternative to them. Graphene and its derivatives with a 2D structure are among the most encouraging materials for gas-sensing purposes, because a 2D lattice with high surface area can maximize the interaction between the surface and gas, and a small variation in the carrier concentration of graphene can cause a notable modulation of electrical conductivity in graphene. However, they show weak sensing performance in pristine form. Hence, doping, and in particular N doping, can be one of the most promising strategies to enhance the gas-sensing features of graphene-based sensors. Herein, we discuss the gas-sensing properties of N-doped graphene and its derivatives. N doping can induce a band gap inside of graphene, generate defects, and enhance the conductivity of graphene, all factors which are beneficial for sensing studies. Additionally, not only is experimental research reviewed in this review paper, but theoretical works about N-doped graphene are also discussed.

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Electrochemical sensing for rapid detection of nandrolone as a doping agent in food commodities using Nitrogen doped-reduced graphene oxide modified electrode

Li,

Jia,

Zhao

2023

Food Measure

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A simple preparation of N-doped reduced graphene oxide as an electrode material for the detection of hydrogen peroxide and glucose

Cited by 11 publications

References 72 publications

Nanozyme Sensor Based on Au Nanoparticles/N-Doped Porous Carbon Composites for Biosensing

Nanozyme Sensor Based on Au Nanoparticles/N-Doped Porous Carbon Composites for Biosensing

N-Doped Graphene and Its Derivatives as Resistive Gas Sensors: An Overview

Electrochemical sensing for rapid detection of nandrolone as a doping agent in food commodities using Nitrogen doped-reduced graphene oxide modified electrode

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