A Simple Method for the Preparation of 2-Amino-4-aryl-3-cyanopyridines by the Condensation of Malononitrile with Aromatic Aldehydes and Alkyl Ketones in the Presence of Ammonium Acetate

Experimental and theoretical studies of the nanostructured {Fe3O4@SiO2@(CH2)3Im}C(CN)3catalyst for 2-amino-3-cyanopyridine preparationviaan anomeric based oxidation

“…Hence, in consequence of the aforementioned biological significances of these versatile structural motifs, a number of procedures have been reported on this topic like microwave or ultrasound irradiation [10][11][12][13], hexadecyldimethyl benzyl ammonium bromide and triethylamine [14], DMF [15], acetic acid [16], Fe 3 O 4 [17], Cellulose-SO 3 H [18]and using earth Lewis acid catalyst [19]. Although, several catalyst and protocol have been studied for the preparation of the 2-amino-3-cyanopyridine derivatives, the methods suffer from one or more imperfection such as toxic solvent like benzene [20], multi-steps reaction pathway [21], high temperature and microwave assistance [22,23], prolonged reaction times and harsh reaction conditions with low yields. In the light of these facts, surveying a straightforward and newer recyclable catalytic environmentally congruous approach for the synthesis of these compounds is still a great day required and an interesting mission to the methodologists and would be valuable.…”

SO4−2/SnO2–catalyzed cyclocondensation for the synthesis of fully functionalized pyridines

“…[9] Multiple component and one pot reactions have established extensive attention for the synthesis of heterocyclic compounds. [13] In recent years, several rules and legislations are made on environmental emission, considering that efficient catalytical methods are much desirable. [13] In recent years, several rules and legislations are made on environmental emission, considering that efficient catalytical methods are much desirable.…”

Synthesis and anticancer activity of novel 2-substituted pyranopyridine derivatives

“…The synthesis of the newly pyrano [4,3-b]pyridinone was carried out according to the reported methods [42][43][44]. Heating an equimolar mixture of 4-pyranone, 2-thiophenecarboxaldehyde and ethyl cyanoacetate in the presence of ammonium acetate and ethanol in a one pot reaction afforded nicotinonitrile compound 1.…”