Density, viscosity, and speed of sound data for (sulfolane + ethyl acetate (EA)), (sulfolane + n-propyl acetate (PA)), and (sulfolane + n-butyl acetate (BA)) were determined at T ) (303.15 to 313.15) K. From this data, excess molar volume and deviation in isentropic compressibility, ∆κ s , have been calculated. The computed properties were fit to a Redlich-Kister polynomial.

This paper presents a 10-step synthetic route for the preparation of a series of new back-to-back coupled 2,6-bis(pyrazol-1-yl)pyridine (bpp) ligands (L0-L3) decorated with tetraoctyl chains. Ligand L1 self-assembles with Zn(2+) ion to form a highly soluble metallo-supramolecular polymer 1 with M(n) ∼ 9600 g/mol. To demonstrate the processability of polymer 1, by following a "top-down" approach periodic one-dimensional fluorescent microstripes were fabricated on a silica substrate.

The excess isentropic compressibilities are computed by measuring the density and speed of sound of binary mixtures of N-methylacetamide with ethyl acetate, ethyl chloroacetate, and ethyl cyanoacetate over the entire range of volume fraction in the temperature range of (303.15 to 318.15) K. The experimental results are fitted to a Redlich-Kister type polynomial equation. Estimated coefficients and standard deviation values are also presented.

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An efficient asymmetric synthetic route for the synthesis of anti-glaucoma agent, (15R)-latanoprost using Corey lactone diol as chiral substrate under Swern oxidation, allylic reduction and Wittig reaction conditions has been developed. In this method, reduction of keto and alkene functional groups has been achieved in a single step using low cost catalyst NiCl 2 /NaBH 4 in methanol. This new synthetic protocol is a good alternative for the synthesis of latanoprost with high stereo selectivity and improved yield.

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Measurement of densities, F, viscosities, η, and ultrasonic speeds, u, have been carried out for binary mixtures of phenylacetonitrile (PAN) with methylethylketone (MEK), methylpropylketone (MPK), methylisobutylketone (MIBK), and diethylketone (DEK) and their pure liquids at T ) 308.15 K over the entire composition range. From these experimental data, excess molar volumes, V E , deviations in viscosity, ∆η, and isentropic compressibility, ∆κ s , of aliphatic ketones with phenylacetonitrile have been calculated. The variation of these properties with composition of the mixture suggests dipole-dipole interactions and charge transfer complex formation between associated phenylacetonitrile molecules and dipolar ketones. The magnitude of the property is found to depend on the chain length of the ketone molecule. These results have been fitted to the Redlich-Kister polynomial using multiparametric nonlinear regression analysis to estimate the binary coefficients and standard errors. The experimental data are used to test the applicability of empirical relations of Grunberg and Nissan, Tamura and Kurata and Hind, and McLaughlin and Ubbelohde for the system studied.

A rapid stability‐indicating reversed phase‐ultrapure liquid chromatography (RP‐UPLC) was developed and validated for the estimation of metformin (MET), linagliptin (LIN), and empagliflozin (EMP) combination in bulk and tablet dosage form using Kromasil C18 column (2.1 × 50 mm, 1.8 μm) as a stationary phase and a mixture solution of 40% phosphate buffer (pH = 3) and 60% acetonitrile as mobile phase at a flow rate of 0.6 mL/min. The detection was performed at 248 nm using a photodiode array detector. The linearity, sensitivity, selectivity, robustness, specificity, precision, and accuracy were determined. The peak area response–concentration curve was rectilinear over the range of 50–150 (MET), 5–15 (LIN), and 10–30 μg/mL (EMP) with quantitation limits of 0.042 (MET), 0.023 (LIN), and 0.059 μg/mL (EMP). The proposed method was successfully validated for the determination of MET, LIN, and EMP simultaneously in combined tablet dosage form. The performance of the proposed method was compared with reported RP‐UPLC methods and found to be rapid and economical. The developed and validated stability‐indicating RP‐UPLC method was appropriate for the quality control and drug analysis.