A simple, label-free, electrochemical DNA parity generator/checker for error detection during data transmission based on “aptamer-nanoclaw”-modulated protein steric hindrance

Wang

et al. 2019

Chem. Sci.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Janus-inspired amphichromatic system that kills two birds with one stone for operating a “DNA Janus Logic Pair” (DJLP) library

Wang

et al. 2019

Chem. Sci.

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“…During the operation, the decimal numbers are first transformed into 4-bit binary numbers, by selecting suitable inputs and assigning 4 distinct bits to inputs, the Pc will produce high output "1" in the presence of even (odd) numbers and low output "0" in the presence of odd (even) ones. [48] Then the even/odd parity can be easily differentiated.…”

Section: Advanced Logic Devices For Specific Arithmetic Functionsmentioning

confidence: 99%

Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications

Wang

et al. 2020

Advanced Science

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DNA computing is recognized as one of the most outstanding candidates of next-generation molecular computers that perform Boolean logic using DNAs as basic elements. Benefiting from DNAs' inherent merits of low-cost, easy-synthesis, excellent biocompatibility, and high programmability, DNA computing has evoked substantial interests and gained burgeoning advancements in recent decades, and also exhibited amazing magic in smart bio-applications. In this review, recent achievements of DNA logic computing systems using multifarious materials as building blocks are summarized. Initially, the operating principles and functions of different logic devices (common logic gates, advanced arithmetic and non-arithmetic logic devices, versatile logic library, etc.) are elaborated. Afterward, state-of-the-art DNA computing systems based on diverse "toolbox" materials, including typical functional DNA motifs (aptamer, metal-ion dependent DNAzyme, G-quadruplex, i-motif, triplex, etc.), DNA tool-enzymes, non-DNA biomaterials (natural enzyme, protein, antibody), nanomaterials (AuNPs, magnetic beads, graphene oxide, polydopamine nanoparticles, carbon nanotubes, DNA-templated nanoclusters, upconversion nanoparticles, quantum dots, etc.) or polymers, 2D/3D DNA nanostructures (circular/interlocked DNA, DNA tetrahedron/polyhedron, DNA origami, etc.) are reviewed. The smart bio-applications of DNA computing to the fields of intelligent analysis/diagnosis, cell imaging/therapy, amongst others, are further outlined. More importantly, current "Achilles' heels" and challenges are discussed, and future promising directions of this field are also recommended.

“…To the best of our knowledge, only a few Pg/Pc systems were constructed based on molecular recognition. [ 11,34,37 ]…”

Section: Figurementioning

confidence: 99%

Illuminating Diverse Concomitant DNA Logic Gates and Concatenated Circuits with Hairpin DNA‐Templated Silver Nanoclusters as Universal Dual‐Output Generators

Zhou

et al. 2020

Advanced Materials

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issues which should be taken seriously. Plenty of logic devices with multi-output signals are implemented by the aid of covalently labeled reporters (e.g., dye or redox), which cause time wastage and high cost. [10][11][12][13][14][15][16][17] In order to generate more than one output signal, it is ineluctable to introduce many other types of substances (e.g., different dyes and unstable hydrogen peroxide), [18,19] which increase complexity of a logic platform and are much detrimental to the repeatability and assembly of different logic systems. In addition, sequence redesign is required for construction of different logic gates, which leads to high cost and low efficiency. Hence, to explore a simple and noncovalent logic platform in a cost-effective manner is urgently demanded.Aimed at surmounting these drawbacks, new DNA-based logic systems should be considered. DNA-templated silver nanoclusters (AgNCs) with excellent fluorescence properties have attracted wide research interests in the field of fabrication of logic devices, [20][21][22][23][24] due to remarkable merits, such as low cost, tunable emission wavelength, ease of preparation, and convenience of utilization in DNA reaction circuits, and noncovalent (so called label-free) and distinctive logic systems could be designed. [21,22,25,26] Recently, a concept of "DNA Janus Logic Pair", also named as "Contrary Logic Pair", was proposed, [18,27] in which two contrary logic gates (positive and negative gates) were obtained via the same one-time reaction, resulting in significant improvement of computing efficiency. However, systematic complexity remains as a constraining factor for effective implementation and integration of DNA-based logic systems. In this study, diverse concomitant contrary logic gates (CCLGs), such as INHIBIT (INH)^IMPLICATION (IMP), XOR^XNOR and MAJORITY (MAJ)^MINORITY (MIN) ("^" stands for "concomitant and contrary"), and extended concatenated logic circuits (e.g., 4-input MAJ||MIN-INH||IMP, "||" stands for "parallel") with specific functions (e.g., parity generator (Pg) and checker (Pc)) were constructed, by utilization of one novel type of hairpin DNA-templated AgNCs (H-AgNCs) as the universal dualfluorescence signal transducer, and based on the mechanism of DNA hybridization and toehold-mediated strand displacement (TSD). Each pair of CCLGs was achieved via the same DNA (YES^NOT, OR^NOR, INHIBIT^IMPLICATION, XOR^XNOR, and MAJORITY^MINORITY) and extended concatenated logic circuits are presented and some of them perform specific functions, such as parity generators and checkers. The introduction of H-AgNCs as noncovalent signal reporters avoids tedious and high-cost labeling procedures. Of note, the concomitant feature of CCLGs attributed to the dual-emitter AgNCs conduces to reducing the time and cost to devise multiple logic gates. As compared to previous ones, this design eliminates numerous substances (e.g., organic dyes) and unstable components (hydrogen peroxide), which not only decreases the complexity of logic performs and impr...