A Janus-inspired amphichromatic system that kills two birds with one stone for operating a “DNA Janus Logic Pair” (DJLP) library

Abstract

Inspired by the myth of Janus, we proposed the concept of DNA Janus Logic Pair (DJLP) and constructed the first amphichromatic system that kills two birds with one stone for operating a multifunctional DJLP library.

Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications

“…Interestingly, this concept was also vividly demonstrated by our recent work. [35] Based on the luminescence quenching ability of oxidized 3, 3′, 5, 5′-tetramethylbenzidine (TMB) toward upconversion nanoparticles (UCNPs) and biocatalytic ability of G-quadruplex DNAzyme, we constructed a universal amphichromatic system that yields double results with half efforts for performing a versatile DNA Janus logic pair library, Figure 3C. In the presence of G4zyme, the generated blue-colored OxTMB after oxidation could quench the emission of UCNPs via inner-filter-effect (IFE), generating the output (1, 0); In the absence of G4zyme, the pale-blue TMB could not quench the luminescence of UCNPs efficiently, producing output (0, 1).…”

“…A) A 4-input concatenated logic circuit, Reproduced with permission- [34] Copyright 2014, Wiley-VCH; B) Scheme of the ternary logic gate; C) A G-quadruplex-based DNA Janus logic pair library, Reproduced with permission. [35] Copyright 2019, Royal Society of Chemistry.…”

Illuminating Diverse Concomitant DNA Logic Gates and Concatenated Circuits with Hairpin DNA‐Templated Silver Nanoclusters as Universal Dual‐Output Generators

“…DNA‐templated silver nanoclusters (AgNCs) with excellent fluorescence properties have attracted wide research interests in the field of fabrication of logic devices, [ 20–24 ] due to remarkable merits, such as low cost, tunable emission wavelength, ease of preparation, and convenience of utilization in DNA reaction circuits, and noncovalent (so called label‐free) and distinctive logic systems could be designed. [ 21,22,25,26 ] Recently, a concept of “DNA Janus Logic Pair”, also named as “Contrary Logic Pair”, was proposed, [ 18,27 ] in which two contrary logic gates (positive and negative gates) were obtained via the same one‐time reaction, resulting in significant improvement of computing efficiency. However, systematic complexity remains as a constraining factor for effective implementation and integration of DNA‐based logic systems.…”

“…Complex concatenated logic circuits have always been pursued to achieve more logic functions [ 41,42 ] and versatile logic program analysis. [ 10,27 ] The remarkable feature of DNA‐based logic gates is ease of integration; hence, a series of concatenated logic circuits were obtained readily, through coupling of diverse constructed CCLGs. F 565 and F 630 are still defined as the dual‐signal outputs.…”

A supramolecular aggregation-based constitutional dynamic network for information processing

“…[1][2][3][4] Compared to silicon-based computer technologies, molecular computing may facilitate in developing smaller and more efficient information devices. [5][6][7] Moreover, molecular computers are composed of reaction networks made of diverse chemicals or biomolecules. Therefore, they may respond directly to physical, 8 chemical, [9][10][11] or biological stimuli, 12 and lead to the development of intelligent computing systems which are adaptive to external stimuli.…”