A simple, fast and low-cost turn-on fluorescence method for dopamine detection using in situ reaction

Zhang, Xiulan; Zhu, Yonggang; Xie, Lihua; Guo, Xuhong; Zhang, Bo; Jia, Xin; Dai, Bin

doi:10.1016/j.aca.2016.09.023

Cited by 84 publications

(47 citation statements)

References 40 publications

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“…Several techniques based on nuclear medicine tomographic imaging, optical sensing, electrochemistry, or high-performance liquid chromatography are currently being developed to reach the limit of detection in the range of nM, even pM and fM [33][34][35][36]. Despite this extreme sensitivity, the selectivity remains an issue.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

et al. 2019

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The rapid electrochemical identification and quantification of neurotransmitters being a challenge in the ever-growing field of neuroelectronics, we aimed to facilitate the electrochemical selective detection of dopamine by functionalizing commercially available electrodes through the deposition of a thin film containing pre-formed gold nanoparticles. The influence of different parameters and experimental conditions, such as buffer solution, fiber material, concentration, and cyclic voltammetry (CV) cycle number, were tested during neurotransmitter detection. In each case, without drastically changing the outcome of the functionalization process, the selectivity towards dopamine was improved. The detected oxidation current for dopamine was increased by 92%, while ascorbic acid and serotonin oxidation currents were lowered by 66% under the best conditions. Moreover, dopamine sensing was successfully achieved in tandem with home-made triple electrodes and an in-house built potentiostat at a high scan rate mode.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

et al. 2019

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“…This structure is analogous to the previously described monardine and azamonardine fluorophores formed between resorcinol and either 3,4-dihydroxyphenethyl alcohol or dopamine, respectively, under mildly basic conditions (pH >8) in the presence of dissolved oxygen at room temperature. 54-55 These conditions are similar to the nanomaterial growth conditions used in our work.…”

Section: Resultsmentioning

confidence: 87%

Untemplated Resveratrol-Mediated Polydopamine Nanocapsule Formation

Amin

Higginson

Korpusik

et al. 2018

ACS Appl. Mater. Interfaces

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Nanocapsules can be designed for applications including drug delivery, catalysis, and biological imaging. The mussel-inspired material polydopamine is a promising shell layer for nanocapsules because of its free radical scavenging capacity, ability to react with a broad range of functional molecules, lack of toxicity, and biodegradability. Previous reports of polydopamine nanocapsule formation have relied on a templating approach. Herein, we report a template-free approach to polydopamine nanocapsule formation in the presence of resveratrol, a naturally occurring anti-inflammatory and antioxidant compound found in red wine and grapes. Synthesis of nanocapsules occurs spontaneously in an ethanolic resveratrol/dopamine·HCl solution at pH 8.5. UV-vis absorbance spectroscopy and X-ray photoelectron spectroscopy indicate that resveratrol is incorporated into the nanocapsules. We also observed the formation of a soluble fluorescent dopamine-resveratrol adduct during synthesis, which was identified by high-performance liquid chromatography, UV-vis spectroscopy, and electrospray ionization mass spectrometry. Using transmission electron microscopy and dynamic light scattering, we studied the influence of solvent composition, dopamine concentration, and resveratrol/dopamine ratio on the nanocapsule diameter and shell thickness. The resulting nanocapsules have excellent free radical scavenging activity as measured by a 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Our work provides a convenient pathway by which resveratrol, and possibly other hydrophobic bioactive compounds, may be encapsulated within polydopamine nanocapsules.

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“…[2] A real-time and accurate detection of UA and DA is desirable and imperative for the diagnosis, treatment and prognosis of the common neurodegenerative disease. [3] Among various analytical methods, [4] electrochemical sensor assay with the ability of providing peak separation of the coexisted compounds have attracted great attention for determination of UA and DA. In recent years, various nanomaterials have recently been employed to design and fabricate the corresponding electrochemical sensors.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, various nanomaterials have recently been employed to design and fabricate the corresponding electrochemical sensors. [5] g-C 3 N 4 have been widely used in catalysis, energy storage, sensing, owing to their exceptionally optical, electronic, physicochemical properties. [6] However, the poor conductivity and the large contact resistance of g-C 3 N 4 make there electrocatalytic performance unsatisfactory, thereby limiting its applications in the electrochemical field.…”

Section: Introductionmentioning

confidence: 99%

g‐C₃N₄/Co Nanohybrids for Ultra‐sensitive Simultaneous Detection of Uric Acid and Dopamine

et al. 2020

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A highly sensitive and selective electrochemical sensor based on g‐C3N4/Co nanohybrids was developed for simultaneous detection of uric acid and dopamine. The g‐C3N4/Co nanohybrid modified electrode shows excellent catalytic response towards the oxidation of uric acid and dopamine, with an anodic peak during differential pulse voltammetry at around 300 mV and 150 mV (Ag/AgCl) taken at pH 7.4, respectively. Good linear relationships between peak current intensities and concentrations were obtained in the range of 1 to 1000 μM and 1 to 400 μM for uric acid and dopamine, and the limit of detection (S/N=3) was 0.4 μM and 0.5 μM, respectively. Further analysis revealed the key role of synergistic effect of Co NPs and g‐C3N4 in boosting the oxidation of uric acid and dopamine. The newly developed sensor was successfully applied to human serum samples for a fast‐electrochemical determination of uric acid. These results demonstrate that the g‐C3N4/Co nanohybrid is a promising candidate of advanced electrode material in electrochemical sensing and other electrocatalytic applications.

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A simple, fast and low-cost turn-on fluorescence method for dopamine detection using in situ reaction

Cited by 84 publications

References 40 publications

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Untemplated Resveratrol-Mediated Polydopamine Nanocapsule Formation

g‐C₃N₄/Co Nanohybrids for Ultra‐sensitive Simultaneous Detection of Uric Acid and Dopamine

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A simple, fast and low-cost turn-on fluorescence method for dopamine detection using in situ reaction

Cited by 84 publications

References 40 publications

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Untemplated Resveratrol-Mediated Polydopamine Nanocapsule Formation

g‐C3N4/Co Nanohybrids for Ultra‐sensitive Simultaneous Detection of Uric Acid and Dopamine

Contact Info

Product

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g‐C₃N₄/Co Nanohybrids for Ultra‐sensitive Simultaneous Detection of Uric Acid and Dopamine