A simple determination method of bromide ion in plasma of methyl bromide workers by head space gas chromatography.

Yamano, Yuko; Itô, Ichiro; Nagao, Noriki; Ishizu, Sumiko

doi:10.1539/joh1959.29.196

Cited by 9 publications

(12 citation statements)

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“…Thus, these patients were suspected to have inhaled a very high concentration of methyl bromide gas and developed poisoning. In support of this assumption, when bromide ion analysis 11) was conducted immediately in the biological samples obtained from the patients, all the three patients were found to have plasma bromide ion concentrations about 20 to 30 times higher (Patient I: 72.9 µg/ml, Patient II: 67.8 µg/ml, and Patient III: 91.5 µg/ml) than normal (3.7 ± 1.5 µg/ml) 11) . Moreover, the latency period of at least one day after the exposure (November 14) until the development of symptoms (dawn of November 16) 1,2,9) , and the presence of neurological symptoms, including convulsions [13][14][15][16] , are consistent with the characteristics of methyl bromide poisoning reported to date 1,8,10,17) .…”

Section: Discussionmentioning

confidence: 79%

“…Moreover, no specific abnormalities in routine laboratory data are noted. The bromide ion concentration in biological samples must be determined for making a definitive diagnosis 11) . In the present report, since three members of a family exhibited similar symptoms, including severe vomiting and neurological symptoms such as convulsions, botulism was suspected at first, and the meal they ate the evening before the onset of the symptoms and the gastric aspirate obtained from Patient III were examined.…”

Section: Discussionmentioning

confidence: 99%

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Three Cases of Acute Methyl Bromide Poisoning in a Seedling Farm Family.

et al. 2001

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Abstract:We encountered three patients (Patient I: 39-year-old man, Patient II: 34-year-old woman, and Patient III: 5-year-old girl) with acute methyl bromide poisoning, which had occurred as a result of exposure to the gas that leaked from methyl bromide cans stored in a warehouse of a seedling farm. Since all three patients exhibited almost the same initial symptoms, i.e., severe vomiting, tonic convulsions and clouding of consciousness, botulism was suspected at first. However, subsequent inquiry revealed that 27 cans of methyl bromide had been stored in the building that the patients lived in, and that the cans had been damaged a few days before the onset of the patients' illness by a thrashing machine that was being moved by them to another location. Inspection revealed that all the cans of methyl bromide had passed the expiry date and were corroded. Even though none of the cans had been used, three cans with a capacity of 750 g were found to be empty. Plasma bromide ion concentrations were determined to be high (72.9 µg/ml, 67.8 µg/ml and 91.5 µg/ml; normal level, <5 µg/ml), and acute methyl bromide poisoning was diagnosed 8 days after admission of the patients to the hospital. Hemodialysis (peritoneal lavage in the case of the child) was performed immediately, after which the plasma bromide ion concentrations returned to normal and the general condition of the patients gradually improved.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Three Cases of Acute Methyl Bromide Poisoning in a Seedling Farm Family.

et al. 2001

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“…Numerous methods have been reported for the determination of bromide in blood and/or urine using ion chromatography [8], gas chromatography (GC) [1,2,[9][10][11][12][13], radio activation analysis [3], inductively coupled plasma mass spectrometry [14], X-ray spectrometry [15], cyclic voltammetry [16] and photometry [17].…”

Section: Introductionmentioning

confidence: 99%

“…Majority of these methods, however, identify bromide only by the retention time [1,2,[8][9][10][11][12][13] or the absorbance [17], thus they lack specificity. Gas chromatography-mass spectrometry (GC-MS) is a popular and specific method for forensic toxicological examination.…”

Section: Introductionmentioning

confidence: 99%

Determination of bromide in whole blood and urine from humans using gas chromatography–mass spectrometry

Kage¹,

Kudo

Ikeda

et al. 2005

Journal of Chromatography B

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“…Urine and blood samples were collected at MeBrhealth examinations conducted biannually, and bromide ion concentrations were measured by headspace gas chromatography (HS-GC) 8) . Serum or urine samples and dimethyl sulfate were placed in a reaction vial, which was then incubated at 85°C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Occupational Exposure in Methyl Bromide Manufacturing Workers: 17-year Follow-up Study of Urinary Bromide Ion Concentration for Biological Monitoring

et al. 2011

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To elucidate the circumstances of their occupational exposure to methyl bromide (MeBr), we conducted a 17-yr study on 124 workers employed by a MeBr manufacturer. Subjects were classified into three groups according to the nature of their work: synthesis group, filling group, and other group. Urinary concentrations of bromide ion (Br -) were assessed, and data attained via MeBr-health examinations were analyzed. The highest Br -concentrations were seen in the synthesis group, with a median value of 13.0 μg/mg CRE (2.5-51.8), followed by the filling group, with a concentration of 11.9 μg/mg CRE (3.1-34.8). Both values were significantly higher than the levels noted in the other group (p<0.001). Three major opportunities for exposure were identified: during exchange of reaction equipment for maintenance or cleaning, during operations to adjust for weight variations after filling canisters, or when canisters were recycled. Overall, however, the workplace environment concentration remained largely below the administrative control level throughout the study period. Therefore, while this was a relatively well-controlled workplace, exposure opportunities still arose when performing certain tasks, indicating the need for ongoing improvement in workplace procedures and underscoring the importance of biological monitoring.

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A simple determination method of bromide ion in plasma of methyl bromide workers by head space gas chromatography.

Cited by 9 publications

References 0 publications

Three Cases of Acute Methyl Bromide Poisoning in a Seedling Farm Family.

Three Cases of Acute Methyl Bromide Poisoning in a Seedling Farm Family.

Determination of bromide in whole blood and urine from humans using gas chromatography–mass spectrometry

Occupational Exposure in Methyl Bromide Manufacturing Workers: 17-year Follow-up Study of Urinary Bromide Ion Concentration for Biological Monitoring

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