A simple and rapid method for determination of paraquat in human urine and plasma by improved solid adsorption using equipment built in-house

Sha, Ou; Cui, Bowen; Hua, Liu; Wang, Yu; Chen, Xiaobing; Chen, Li; Wang, Shujun

doi:10.1007/s13738-019-01676-5

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…In this review, recent advances in sample preparation methods for PQ and DQ analysis are discussed. The sample treatment methods for PQ and DQ ( Table 1 ) include protein precipitation [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ], liquid–liquid extraction (LLE) [ 20 , 21 ], solid-phase extraction (SPE) [ 22 , 23 , 24 , 25 , 26 , 27 ], solid-phase microextraction (SPME) [ 28 , 29 ], liquid-phase microextraction (LPME) [ 10 , 30 , 31 ], and magnetic dispersed solid phase extraction (MDSPE) [ 32 , 33 , 34 , 35 , 36 ].…”

Section: Sample Treatment Methodsmentioning

confidence: 99%

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Guo

Gao

2023

Molecules

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Paraquat (PQ) and diquat (DQ) are quaternary ammonium herbicides which have been used worldwide for controlling the growth of weeds on land and in water. However, PQ and DQ are well known to be toxic. PQ is especially toxic to humans. Moreover, there is no specific antidote for PQ poisoning. The main treatment for PQ poisoning is hemoperfusion to reduce the PQ concentration in blood. Therefore, it is essential to be able to detect PQ and DQ concentrations in biological samples. This critical review summarizes the articles published from 2010 to 2022 and can help researchers to understand the development of the sample treatment and analytical methods for the determination of PQ and DQ in various types of biological samples. The sample preparation includes liquid–liquid extraction, solid-phase extraction based on different novel materials, microextration methods, and other methods. Analytical methods for quantifying PQ and DQ, such as different chromatography and spectroscopy methods, electrochemical methods, and immunological methods, are illustrated and compared. We focus on the latest advances in PQ and DQ treatment and the application of new technologies for these analyses. In our opinion, tandem mass spectrometry is a good choice for the determination of PQ and DQ, due to its high sensitivity, high selectivity, and high accuracy. As far as we are concerned, the best LOD of 4 pg/mL for PQ in serum can be obtained.

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Section: Sample Treatment Methodsmentioning

confidence: 99%

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Guo

Gao

2023

Molecules

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“…The complexity, time consumption, and equipment demand of most approaches makes them impractical, especially in resource-poor environments. Improved sample preparation approaches for the extraction of PQ or DQ from plasma and urine samples, such as solid phase extraction [ 13 ], liquid phase extraction [ 14 ], and so on, have been developed [ 15 ]. However, the complex procedure including protein precipitation [ 16 ] by acetonitrile or protein removal by ultrafiltration membrane could reduce the sensitivity of the detection method and increase the analysis time.…”

Section: Introductionmentioning

confidence: 99%

Separation and Determination of Paraquat and Diquat in Human Plasma and Urine by Magnetic Dispersive Solid Phase Extraction Coupled with High-Performance Liquid Chromatography

Sha

Cui

Chen

et al. 2020

Journal of Analytical Methods in Chemistry

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A magnetic dispersive solid phase extraction method coupled with high-performance liquid chromatography was proposed for the simultaneous separation and determination of paraquat (PQ) and diquat (DQ) in human plasma and urine samples. Based on the reduction of PQ and DQ to a blue radical and yellow-green radical by sodium dithionite in an alkaline medium, a fast colorimetric method was also developed for the fast detection of PQ or DQ. In this paper, CoFe2O4@SiO2 magnetic nanoparticles were used as the adsorbent for the magnetic dispersive solid phase extraction of paraquat and diquat, and these two analytes were found to be eluted directly from the adsorbent by NaOH solution. The main factors affecting the extraction efficiency including amount of extractant, extraction time, sample volume, sample solution pH, and elution volume were optimized. Under the optimized experimental conditions, the calibration curve was linear at a concentration range of 28.5–570.2 μg/L, and the correlation coefficient of paraquat and diquat was 0.9986 and 0.9980, respectively. The limits of detection of paraquat and diquat were 4.5 μg/L and 4.3 μg/L. The proposed MSPE-HPLC method was successfully applied to the detection of the paraquat and diquat in human plasma and urine with satisfied recoveries of PQ and DQ in the range of 87.5%–98.7%.

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A rapid and reliable immunochromatographic strip for detecting paraquat poinsoning in domestic water and real human samples

Duan

Yi³

et al. 2022

Environmental Pollution

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A simple and rapid method for determination of paraquat in human urine and plasma by improved solid adsorption using equipment built in-house

Cited by 4 publications

References 26 publications

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Separation and Determination of Paraquat and Diquat in Human Plasma and Urine by Magnetic Dispersive Solid Phase Extraction Coupled with High-Performance Liquid Chromatography

A rapid and reliable immunochromatographic strip for detecting paraquat poinsoning in domestic water and real human samples

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