A Simple and Efficient Procedure for a 2-Pyridones Synthesis under Solvent-Free Conditions

Abstract

A new series of 3-cyano-2-pyridones derivatives have been prepared by reaction of enaminonitriles with pri-mary amine under solvent free condition. This procedure have the advantage of high yields and being environ-mentally-friendly

Green Synthesis of Novel 5-Arylazo-2-[(2S, 3S, 4R, 5R)-3, 4, 5-Trihydroxy-6-(Hydroxymethyl) Tetrahydro-2H-Pyran-2-Yloxy]-4, 6-Dimethyl 3-Nicotinonitrile

“…General technique for green formation of arylazo pyridone glucosides had been used [14] [15]. Scheme 1.…”

“…For example, 3-cyano-4, 6-Dimethyl-5-arylazo-2(1H)-pyridinones (1a-e) [14] [15] were allowed to be reacted with acetylaed-α-D-glucopyranosyl bromide derivative for 2 minutes to give (2a-e) in about 91% yield. The same nucleosides, (2a-e) were be gained in very high yields by the reaction of the K-salt of pyridnone which was generated in situ, using potassium hydride and an activated sugar moiety.…”

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

“…This method is time consuming and suffers from some difficulties especially with propenones bearing heterocyclic moieties. Another approach involves the condensation of an active acetyl function and the appropriate arylidinecyanoacetate, arylidinethiocyanoacetamide or arylidinemalononitrile in the presence of ammonium acetate as a source of ammonia [43]. The one-step multi-component reaction approach was effectively employed since it is easy to perform and gives better yields in less reaction times.…”

Green Synthesis of Novel 5-Arylazo-2- [(2S, 3S, 4R, 5R)-3, 4, 5- trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethyl 3-nicotinonitrile.

“…Many uses of pyridines derivatives were investigated in the recent decades especially fluorinated derivatives. One of the recent researches discovered that high tuberculostearic activity of pyridine was observed [1,2].…”

“…Many uses of pyridines derivatives were investigated in the recent decades especially fluorinated derivatives. One of the recent researches discovered that high tuberculostearic activity of pyridine was observed [1,2].Also from the amazing character of some pyridine is its high fluorescence activities which was used as molecular sensor of picric acid [3].It has been of great importance in the exploring of some novel antimicrobial compounds in veterinary as well as human medicine worldwide. Genetic mutation and acquisition of mobile drug resistance genes of microorganisms is a very great resistance and barrier in treating animal and human patients with infectious diseases [4,5].…”