A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: Syringe-foaming using a viscous hydrophilic polymeric solution

Zhang, Jingtao; Liu, Weizhen; Gauthier, Olivier; Sourice, Sophie; Pilet, Paul; Réthoré, Gildas; Khairoun, Khalid; Bouler, Jean‐Michel; Tancret, Franck; Weiss, Pierre

doi:10.1016/j.actbio.2015.11.055

Cited by 82 publications

(62 citation statements)

References 72 publications

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“…Calcium phosphate (CaP) cements, for instance, well resemble bone tissue chemical/functional properties, being both biocompatible and bioactive. However, low tensile strength and high brittleness are among the main drawbacks of such materials [26,27]. CaP showed ability in promoting bone repair, although they typically provide poor revascularisation/mineralisation, limited life-time, and inability to adapt to skeletal changes [28].…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Composite Hydrogels for Bone Regeneration

et al. 2016

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Over the past few decades, bone related disorders have constantly increased. Among all pathological conditions, osteoporosis is one of the most common and often leads to bone fractures. This is a massive burden and it affects an estimated 3 million people only in the UK. Furthermore, as the population ages, numbers are due to increase. In this context, novel biomaterials for bone fracture regeneration are constantly under development. Typically, these materials aim at favoring optimal bone integration in the scaffold, up to complete bone regeneration; this approach to regenerative medicine is also known as tissue engineering (TE). Hydrogels are among the most promising biomaterials in TE applications: they are very flexible materials that allow a number of different properties to be targeted for different applications, through appropriate chemical modifications. The present review will focus on the strategies that have been developed for formulating hydrogels with ideal properties for bone regeneration applications. In particular, aspects related to the improvement of hydrogels’ mechanical competence, controlled delivery of drugs and growth factors are treated in detail. It is hoped that this review can provide an exhaustive compendium of the main aspects in hydrogel related research and, therefore, stimulate future biomaterial development and applications.

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Section: Bone Tissue Engineeringmentioning

confidence: 99%

Composite Hydrogels for Bone Regeneration

et al. 2016

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“…Several materials have been developed and analyzed to be used for this purpose, including bioactive ceramics such as hydroxyapatite (HA) [5], beta-tricalcium phosphate (b-TCP) [6], biphasic calcium phosphate (BCP) [7], calcium phosphate 2 International Journal of Polymer Science cements [8], bioactive glass [9], and several biodegradable polymers [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effects of Genipin Concentration on Cross-Linked Chitosan Scaffolds for Bone Tissue Engineering: Structural Characterization and Evidence of Biocompatibility Features

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Cancelli

et al. 2017

International Journal of Polymer Science

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Genipin (GN) is a natural molecule extracted from the fruit of Gardenia jasminoides Ellis according to modern microbiological processes. Genipin is considered as a favorable cross-linking agent due to its low cytotoxicity compared to widely used cross-linkers; it cross-links compounds with primary amine groups such as proteins, collagen, and chitosan. Chitosan is a biocompatible polymer that is currently studied in bone tissue engineering for its capacity to promote growth and mineral-rich matrix deposition by osteoblasts in culture. In this work, two genipin cross-linked chitosan scaffolds for bone repair and regeneration were prepared with different GN concentrations, and their chemical, physical, and biological properties were explored. Scanning electron microscopy and mechanical tests revealed that nonremarkable changes in morphology, porosity, and mechanical strength of scaffolds are induced by increasing the cross-linking degree. Also, the degradation rate was shown to decrease while increasing the crosslinking degree, with the high cross-linking density of the scaffold disabling the hydrolysis activity. Finally, basic biocompatibility was investigated in vitro, by evaluating proliferation of two human-derived cell lines, namely, the MG63 (human immortalized osteosarcoma) and the hMSCs (human mesenchymal stem cells), as suitable cell models for bone tissue engineering applications of biomaterials.

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“…112,140 HPMC-Si hydrogels could encapsulate chondrocytes and be injected for cartilage tissue regeneration. 136 They were also used for other applications such as bone repair 141 and substitution, 142 cell-based tissue engineering [143][144][145] and intramyocardial cell delivery. 146 ( Figure 19).…”

Section: Nanostructured Hydrogels As Biomaterialsmentioning

confidence: 99%