A silver‐sulfadiazine‐impregnated synthetic wound dressing composed of poly‐l‐leucine spongy matrix: An evaluation of clinical cases

Yoshimitsu, Kengo; Kim, Eikichi; Kenmochi, Makoto; K, Ui; Kageyama, Hiromi; Nakamura, Motonobu; Shioya, Nobuyuki

doi:10.1002/jab.770030211

Cited by 29 publications

(8 citation statements)

References 16 publications

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“…Recently, wound dressings or artificial skins containing antibiotics have been developed for the inhibition of wound infection. These devices incorporate antibiotics in the wound dressing together with bilayer artificial skin and silver‐impregnated porcine xenograft 22–24. Wound infection can be decreased with the treatment of wound dressings that incorporate antibiotics, and the laborious replacement of wound dressings and the damage inflicted on the newly formed epithelium can be avoided.…”

Section: Introductionmentioning

confidence: 99%

Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery

Shyu

et al. 2001

J. Biomed. Mater. Res.

285

124

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A novel bilayer chitosan membrane was prepared by a combined wet/dry phase inversion method and evaluated as a wound dressing. This new type of bilayer chitosan wound dressing, consisting of a dense upper layer (skin layer) and a sponge-like lower layer (sublayer), is very suitable for use as a topical delivery of silver sulfadiazine (AgSD) for the control of wound infections. Physical characterization of the bilayer wound dressing showed that it has excellent oxygen permeability, that it controls the water vapor transmission rate, and that it promotes water uptake capability. AgSD dissolved from bilayer chitosan dressings to release silver and sulfadiazine. The release of sulfadiazine from the bilayer chitosan dressing displayed a burst release on the first day and then tapered off to a much slower release. However, the release of silver from the bilayer chitosan dressing displayed a slow release profile with a sustained increase of silver concentration. The cultures of Pseudomonas aeruginosa and Staphylococcus aureus in agar plates showed effective antimicrobial activity for 1 week. In vivo antibacterial tests confirmed that this wound dressing is effective for long-term inhibition of the growth of Pseudomonas aeruginosa and Staphylococcus aureus at an infected wound site. The results in this study indicate that the AgSD-incorporated bilayer chitosan wound dressing may be a material with potential antibacterial capability for the treatment of infected wounds.

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Section: Introductionmentioning

confidence: 99%

Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery

Shyu

et al. 2001

J. Biomed. Mater. Res.

285

124

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“…To enhance the in vivo pharmacological efficacy, several wound dressings impregnated with Ag‐SD, released in a sustained manner, have been developed. Various materials have been used for these dressings, such as porcine skin,36–38 polymer gel composed of poly‐2‐hydroxyethylmethacrylate and poly(ethyleneglycol),39 polymeric sheet composed of polyethyleneglycol, hydroxyethyl methacrylate, and dimethyl sulfoxide,40, 41 poly(L‐leucine),42, 43 and polyelectrolyte complex composed of chitosan and sodium alginate 44. However, it is difficult to apply these wound dressings to full‐thickness skin defects because they are not converted into regenerated connective tissue similar to true dermis (dermis‐like tissue).…”

Section: Discussionmentioning

confidence: 99%

Development of an artificial dermis preparation capable of silver sulfadiazine release

Kawai

Suzuki

Tabata

et al. 2001

J. Biomed. Mater. Res.

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This article describes the antibacterial effects of an artificial dermis impregnated with silver sulfadiazine (Ag-SD) in vitro as well as in vivo. In the in vitro test, silver release from the artificial dermis impregnated with Ag-SD, by immersion in collagenase solution was controlled by the degradation of the collagen sponge. The artificial dermis impregnated with 3% or higher doses of Ag-SD completely suppressed the growth of Pseudomonas aeruginosa (Ps.) or Staphylococcus aureus (St.). The cytotoxicity test revealed that impregnation of 5% or higher doses of Ag-SD suppressed the growth of fibroblasts. However, when the artificial dermis impregnated with Ag-SD was implanted into full-thickness skin defects on the backs of guinea pigs, no tissue damage was histologically observed around the implanted site of the dermis. In the in vivo test, the artificial dermis impregnated with 10% Ag-SD, which was grafted on experimentally contaminated wounds in the backs of guinea pigs, macroscopically suppressed degradation of the collagen sponge, and significantly reduced the growth of both Ps. and St., compared with artificial dermis without Ag-SD. We conclude that collagen sponge impregnated with Ag-SD is a promising artificial dermis applicable to treat contaminated wounds.

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“…In this regard, we recently developed an AgSD-impregnated poly-Lleucine wound dressing, XEMEX Epiceul (Nippon Zeon Co ., Ltd., Tokyo, Japan) . [9][10][11][12][13] In this study, a new bilaminar wound dressing with a drug delivery capability was developed, and basic and clinical evaluations of this wound dressing were provided.…”

Section: Agsdmentioning

confidence: 99%

Development of a new wound dressing with antimicrobial delivery capability

Yoshimitsu¹,

Shiraishi

Shirasaki

et al. 1994

Wound Repair Regeneration

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A bilaminar wound dressing composed of an outer membrane and an inner three-dimensional matrix of a fabric or a sponge may be considered to constitute an ideal structure that promotes wound healing: the outer membrane prevents body fluid loss, controls water evaporation, and protects the wound surface from bacterial invasion, and the inner matrix encourages adherence by tissue growth into the matrix. Using this concept, we developed a biosynthetic wound dressing with a drug delivery capability. This medicated wound dressing is composed of a spongy sheet of a chitosane derivative and collagen mixture that is laminated to an antimicrobial-impregnated polyurethane membrane. In this study, a gentamycin sulfate-impregnated wound dressing was prepared and evaluated. The antimicrobial efficacy of this wound dressing was examined on an agar plate seeded with Pseudomonas aeruginosa. Also, the cytotoxicity of an antimicrobial released from this wound dressing was examined in an in vitro system with cultured skin substitutes. Both in vitro tests have shown that this wound dressing is capable of suppressing bacterial growth and minimizing cellular damage. In addition, in the treatment of wounds inflicted on rats and rabbits, this wound dressing was shown to be efficacious in covering full-thickness and split-thickness skin defects. Finally, the efficacy of this wound dressing was evaluated in a nonrandomized open-label study of 31 clinical cases. In 31 cases treated with this wound dressing, good or excellent wound healing was achieved.

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A silver‐sulfadiazine‐impregnated synthetic wound dressing composed of poly‐l‐leucine spongy matrix: An evaluation of clinical cases

Cited by 29 publications

References 16 publications

Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery

Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery

Development of an artificial dermis preparation capable of silver sulfadiazine release

Development of a new wound dressing with antimicrobial delivery capability

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