A silicon microfluidic ultrasonic separator

Harris, Nick; Hill, Martyn; Beeby, Steve; Shen, Yijun; White, NM; Hawkes, Jeremy J.; Coakley, W. Terence

doi:10.1016/s0925-4005(03)00448-9

Cited by 132 publications

(98 citation statements)

References 3 publications

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“…To achieve these, various techniques have been developed to be used in microsystems such as optical tweezers [1], magnetophoresis [2], acoustic means [3,4,5] and dielectrophoresis (DEP). Among these, DEP is one of the most popular methods for particle manipulation in microsystems due to (i) its favorable scaling effects [6], (ii) the simplicity of the instrumentation and (iii) its ability to induce both negative and positive forces [7].…”

Section: Introductionmentioning

confidence: 99%

Continuous particle separation based on electrical properties using alternating current dielectrophoresis

Çetin

2009

Electrophoresis

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A design of a microchannel for continuous separation of particles based on alternating current dielectrophoretic is studied. The geometric design parameters are determined by analyzing the dielectrophoresis force field inside the microchannel corresponding to the most efficient separation. The trajectories of 5 and 10 mm spherical particles are derived analytically using Lagrangian tracking method to examine the feasibility and the effectiveness of the design. The effects of the mean flow velocity inside the channel and the applied voltage across the channel on the performance of the separation are also discussed.

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Section: Introductionmentioning

confidence: 99%

Continuous particle separation based on electrical properties using alternating current dielectrophoresis

Çetin

2009

Electrophoresis

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“…Planar USW systems may employ resonators that are larger than a wavelength and contain multiple pressure nodal planes [12,13], but for microfluidic scale devices, a resonant cavity with an axial dimension that is lower than the operating wavelength may be employed [14][15][16]. Such sub-wavelength resonators typically rely for their operation on precise positioning of the pressure node, to which particles will migrate.…”

Section: Introductionmentioning

confidence: 99%

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

2008

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a b s t r a c t Several approaches have been described for the manipulation of particles within an ultrasonic field. Of those based on standing waves, devices in which the critical dimension of the resonant chamber is less than a wavelength are particularly well suited to microfluidic, or ''lab on a chip" applications. These might include pre-processing or fractionation of samples prior to analysis, formation of monolayers for cell interaction studies, or the enhancement of biosensor detection capability. The small size of microfluidic resonators typically places tight tolerances on the positioning of the acoustic node, and such systems are required to have high transduction efficiencies, for reasons of power availability and temperature stability. Further, the expense of many microfabrication methods precludes an iterative experimental approach to their development. Hence, the ability to design sub-wavelength resonators that are efficient, robust and have the appropriate acoustic energy distribution is extremely important. This paper discusses one-dimensional modelling used in the design of ultrasonic resonators for particle manipulation and gives example of their uses to predict and explain resonator behaviour. Particular difficulties in designing quarter wave systems are highlighted, and modelling is used to explain observed trends and predict performance of such resonators, including their performance with different coupling layer materials.

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“…The standing wave is maintained by a passive reflecting layer at the far side of the fluid, as shown in Such a resonator may be many wavelengths across, resulting in multiple planes into which cells are gathered [32]. Generally, the fluid layers in the microdevices considered here will be less than a wavelength thick and will gather cells into a single nodal plane [33,34]. An alternative arrangement, the transversal resonator, has been used extensively by Laurell's group in Lund [30,35].…”

Section: Devices For On-chip Ultrasonic Manipulationmentioning

confidence: 99%

Ultrasound assisted particle and cell manipulation on-chip

Mulvana

Cochran

Hill

2013

Advanced Drug Delivery Reviews

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Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.

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A silicon microfluidic ultrasonic separator

Cited by 132 publications

References 3 publications

Continuous particle separation based on electrical properties using alternating current dielectrophoresis

Continuous particle separation based on electrical properties using alternating current dielectrophoresis

Modelling for the robust design of layered resonators for ultrasonic particle manipulation

Ultrasound assisted particle and cell manipulation on-chip

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