A short-term evaluation of a thermoplastic polyurethane implant for osteochondral defect repair in an equine model

Korthagen, N.M.; Brommer, Harold; Hermsen, G.; Plomp, Saskia; Melsom, G.; Coeleveld, K.; Mastbergen, S.C.; Weinans, Harrie; Buul, W. van; Weeren, P.R. van

doi:10.1016/j.tvjl.2019.105340

Cited by 14 publications

(19 citation statements)

References 30 publications

(32 reference statements)

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“…Perhaps, the focus should shift from the elusive goal of regeneration to achieving functional long‐term repair. In this light, the resorbable nature of the implant materials might be questioned and materials with half‐life that are similarly as long as those of the natural components of the extracellular matrix, for example polyurethane elastomers might be considered . The need for clinically and commercially viable methods promotes ‘simplification’ of the biological process of osteochondral repair.…”

Section: Experimental Studies On Surgical Techniquesmentioning

confidence: 99%

Surgical osteochondral defect repair in the horse—a matter of form or function?

Fugazzola

Weeren

2020

Equine Veterinary Journal

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Focal cartilaginous and osteochondral lesions can have traumatic or chondropathic degenerative origin. The fibrocartilaginous repair tissue that forms naturally, eventually undergoes fibrillation and degeneration leading to further disruption of joint homeostasis. Both types of lesion will therefore eventually lead to activity‐related pain, swelling and decreased mobility and will frequently progress to osteoarthritis. Most attempts at realising cartilage regeneration have so far resulted in cartilage repair (and not regeneration). The aim of this article was to review experimental research on surgical cartilage restoration techniques performed so far in equine models. Currently available surgical options for treatment of osteochondral lesions in the horse are summarised. The experimental validity of equine experimental models is addressed and finally possible avenues for further research are discussed.

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Section: Experimental Studies On Surgical Techniquesmentioning

confidence: 99%

Surgical osteochondral defect repair in the horse—a matter of form or function?

Fugazzola

Weeren

2020

Equine Veterinary Journal

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“…In addition, a recent study has shown that the mechanical properties of AC, namely its swelling behaviour, can be mimicked by composite gels of poly(acrylic acid) microparticles embedded within poly(vinyl alcohol) (PVA) matrices [ 130 ]. As a final example, polyurethane (PU)-based scaffolds have demonstrated satisfactory mechanical properties and the ability to sustain chondrocyte and MSC proliferation and ECM deposition [ 131 ], even though in vivo studies in an equine OC defect model showed very limited efficacy of a PU elastomer in promoting hyaline cartilage formation and tissue regeneration [ 132 ].…”

Section: Osteochondral Tissue Engineeringmentioning

confidence: 99%

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Gonçalves¹,

Moreira²,

Weber

et al. 2021

Pharmaceutics

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The socioeconomic impact of osteochondral (OC) damage has been increasing steadily over time in the global population, and the promise of tissue engineering in generating biomimetic tissues replicating the physiological OC environment and architecture has been falling short of its projected potential. The most recent advances in OC tissue engineering are summarised in this work, with a focus on electrospun and 3D printed biomaterials combined with stem cells and biochemical stimuli, to identify what is causing this pitfall between the bench and the patients’ bedside. Even though significant progress has been achieved in electrospinning, 3D-(bio)printing, and induced pluripotent stem cell (iPSC) technologies, it is still challenging to artificially emulate the OC interface and achieve complete regeneration of bone and cartilage tissues. Their intricate architecture and the need for tight spatiotemporal control of cellular and biochemical cues hinder the attainment of long-term functional integration of tissue-engineered constructs. Moreover, this complexity and the high variability in experimental conditions used in different studies undermine the scalability and reproducibility of prospective regenerative medicine solutions. It is clear that further development of standardised, integrative, and economically viable methods regarding scaffold production, cell selection, and additional biochemical and biomechanical stimulation is likely to be the key to accelerate the clinical translation and fill the gap in OC treatment.

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“…osteochondral implant [37], breast reconstruction [38], and so on, have been documented based on the fine tuning of the soft and hard segments. Moreover, the progress in processes, additives, and techniques has allowed infinity of formulations that contributed to increase the number of applications for PU materials that continue instigating the growing global market [39].…”

Section: Traditional Routementioning

confidence: 99%

PDMS-urethanesil hybrid multifunctional materials: combining CO2 use and sol–gel processing

Günther

Lima

Aguiar

et al. 2020

J Sol-Gel Sci Technol

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CO2 mitigation by cycloaddition to bis-epoxides to obtain bis-cyclocarbonates (CC) paved one way to a new class of polyurethanes (PUs), the non-isocyanate polyurethanes (NIPUs). By using molecules functionalized with alkoxysilyl groups as end chain it is possible to obtain hybrid NIPUs, also called urethanesils, by Sol-Gel chemistry. Using bis-cyclocarbonate polydimethylsiloxane (CCPDMS) with proper diamines and end-chain amino silanes followed by sol-gel processing leads to versatile hybrid non-isocyanate polydimethylsiloxane urethanes (PDMS-urethanesil). This review reports-besides our recent studies about PDMS-urethanesil materials-the sol-gel chemistry applied to synthesize urethanesil and its applications. While the antimicrobial, photochromic, and anticorrosion properties of urethanesil loaded with phosphotungstic acid as well as the luminescent effect of material loaded with Eu 3+ have already been reported, antimicrobial features of urethanesil loaded with phosphoric acid are our newest findings which we herein report for the first time. The impact of the inorganic acid used on the sol-gel process is highlighted together with the importance of antibiofouling properties. Although the antibiofouling mechanism is still under investigation, the broad spectrum of action of phosphoric acid loaded urethanesil is worth mentioning, since it has been tested to be efficient against some pathogenic bacteria including a drug resistant Staphylococcus aureus strain as well as pathogenic fungi and yeast. Due to the simple, straightforward, and highly reproducible synthesis as well as the opportunity to obtain versatile materials with tuneable mechanical and physical properties, this new class of hybrid materials promises to be applicable in different industrial fields.

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A short-term evaluation of a thermoplastic polyurethane implant for osteochondral defect repair in an equine model

Cited by 14 publications

References 30 publications

Surgical osteochondral defect repair in the horse—a matter of form or function?

Surgical osteochondral defect repair in the horse—a matter of form or function?

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

PDMS-urethanesil hybrid multifunctional materials: combining CO2 use and sol–gel processing

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