A Short Review on Genes Regulating Biosynthesis of Major Secondary Metabolites

Kashyap, Arun Kumar; Dubey, Sumit Kumar; Shah, Sujit; Kumar, Ajay

doi:10.1007/978-981-19-5779-6_20

Cited by 2 publications

(4 citation statements)

References 109 publications

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“…This unique regulatory mechanism helps maintain a balance in carbon flow between lignin and flavonoids in the plant [60]. Notably, a single MYB transcription factor can exert control over multiple genes within a pathway, and, conversely, a single gene can be subject to regulation by several MYB proteins [78]. Often, TFs are presented in the form of complexes.…”

Section: Biosynthesis Of Polyphenolsmentioning

confidence: 99%

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Polyphenols in Plants: Structure, Biosynthesis, Abiotic Stress Regulation, and Practical Applications (Review)

Zagoskina,

Zubova,

Nechaeva

et al. 2023

IJMS

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Phenolic compounds or polyphenols are among the most common compounds of secondary metabolism in plants. Their biosynthesis is characteristic of all plant cells and is carried out with the participation of the shikimate and acetate-malonate pathways. In this case, polyphenols of various structures are formed, such as phenylpropanoids, flavonoids, and various oligomeric and polymeric compounds of phenolic nature. Their number already exceeds 10,000. The diversity of phenolics affects their biological activity and functional role. Most of their representatives are characterized by interaction with reactive oxygen species, which manifests itself not only in plants but also in the human body, where they enter through food chains. Having a high biological activity, phenolic compounds are successfully used as medicines and nutritional supplements for the health of the population. The accumulation and biosynthesis of polyphenols in plants depend on many factors, including physiological–biochemical, molecular–genetic, and environmental factors. In the review, we present the latest literature data on the structure of various classes of phenolic compounds, their antioxidant activity, and their biosynthesis, including their molecular genetic aspects (genes and transfactors). Since plants grow with significant environmental changes on the planet, their response to the action of abiotic factors (light, UV radiation, temperature, and heavy metals) at the level of accumulation and composition of these secondary metabolites, as well as their metabolic regulation, is considered. Information is given about plant polyphenols as important and necessary components of functional nutrition and pharmaceutically valuable substances for the health of the population. Proposals on promising areas of research and development in the field of plant polyphenols are presented.

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Section: Biosynthesis Of Polyphenolsmentioning

confidence: 99%

“…Often, TFs are presented in the form of complexes. The MBW complex, composed of MYB, bHLH, and WD40 proteins, is a central transcriptional regulator in flavonoid biosynthesis [ 78 ]. This complex activates structural genes responsible for the flavonoid biosynthesis process, particularly anthocyanins.…”

Section: Biosynthesis Of Polyphenolsmentioning

confidence: 99%

Polyphenols in Plants: Structure, Biosynthesis, Abiotic Stress Regulation, and Practical Applications (Review)

Zagoskina,

Zubova,

Nechaeva

et al. 2023

IJMS

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“…Thousands of these secondary metabolites have been found, and the list is growing. Secondary metabolites are broadly classed as alkaloids, terpenoids, and phenolics [ 16 , 17 , 18 ] ( Figure 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…Thousands of these secondary metabolites have been found, and the list is growing. Secondary metabolites are broadly classed as alkaloids, terpenoids, and phenolics [16][17][18] (Figure 2). Because the number and kinds of secondary metabolites in a single herb vary [16], the pharmacological effects of herbs are specific to certain plant species or groups of plants.…”

Section: Introductionmentioning

confidence: 99%

Management of Obesity-Related Inflammatory and Cardiovascular Diseases by Medicinal Plants: From Traditional Uses to Therapeutic Targets

Saad

2023

Biomedicines

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Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce cardiac function, induce arrhythmias, and finally, cause heart failure. The majority of current CVD treatment plans concentrate on reducing risk factors such as hyperlipidemia, type 2 diabetes, and hypertension. One such strategy could be inflammation reduction. Numerous in vitro, animal, and clinical studies indicate that obesity is associated with low-grade inflammation. Recent studies have demonstrated the potential of medicinal plants and phytochemicals to cure and prevent obesity and inflammation. In comparison to conventional therapies, the synergistic effects of several phytochemicals boost their bioavailability and impact numerous cellular and molecular targets. Focusing on appetite, pancreatic lipase activity, thermogenesis, lipid metabolism, lipolysis and adipogenesis, apoptosis in adipocytes, and adipocyte life cycle by medicinal plants and phytochemicals represent an important goal in the development of new anti-obesity drugs. We conducted an extensive review of the literature and electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus, for collecting data on the therapeutic effects of medicinal plants/phytochemicals in curing obesity and its related inflammation and CVD diseases, including cellular and molecular mechanisms, cytokines, signal transduction cascades, and clinical trials.

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A Short Review on Genes Regulating Biosynthesis of Major Secondary Metabolites

Cited by 2 publications

References 109 publications

Polyphenols in Plants: Structure, Biosynthesis, Abiotic Stress Regulation, and Practical Applications (Review)

Polyphenols in Plants: Structure, Biosynthesis, Abiotic Stress Regulation, and Practical Applications (Review)

Management of Obesity-Related Inflammatory and Cardiovascular Diseases by Medicinal Plants: From Traditional Uses to Therapeutic Targets

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