A Short Review on Chemical Composition Therapeutic Use and Enzyme Inhibition Activities of Cymbopogon species

Dutta, Sukriti; Munda, Sunita; Lal, Mohan; Bhattacharyya, P. R.

doi:10.17485/ijst/2016/v9i46/87046

Cited by 31 publications

(19 citation statements)

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“…Cymbopogon citratus and C. winterianus contain high amounts of geraniol, geranial, and cadinol isomers. Considerable amounts of elemol and limonene have also been reported in both C. proximus and C. winterianus [11,[38][39][40]. Our present findings, along with the results of previous studies, highlight the potential protective effects of Cymbopogon species against CVDs.…”

Section: Discussionsupporting

confidence: 84%

“…Moreover, extracts from C. citratus and C. winterianus are shown to reduce blood pressure by modulating the calcium pathway and decreasing heart rate by activating cardiac muscarinic receptors [36,37]. Also, C. citratus and C. jwarancusa extracts are reported to possess antioxidant, antidiabetic, and hypolipidemic properties and protect against endothelial dysfunction [10][11][12]17,18,21]. Of specific interest, C. proximus extracts are reported to possess profound antioxidant effects and are able to decrease blood pressure in both normotensive and hypertensive rats [21,23,24].…”

Section: Discussionmentioning

confidence: 99%

“…The use of Cymbopogon species in traditional medicine is well documented. Several illnesses, such as coughs, fever, infections, cancer, and digestive disorders, have reportedly been treated using various species of Cymbopogon worldwide [10,11]. Moreover, in vivo and in vitro studies have revealed beneficial pharmacological effects of Cymbopogon spp., including anticancer, cardioprotective, anti-inflammatory, antioxidant, antidiabetic, anticholinesterase, antibacterial, and antifungal properties [12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

et al. 2020

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Cymbopogon proximus (Halfabar), a wild plant that is usually used in folk medicine due to its diuretic and antispasmodic effects, was shown to exhibit several cardiovascular protective actions such as antidiabetic, antihypertensive, antioxidant, and antinflammatory effects. However, no reports are available regarding the investigation of the role of Cymbopogon proximus essential oil on cardiac hypertrophy. Therefore, the goals of the present study were to find whether Cymbopogon proximus could alleviate isoproterenol induced‐cardiac hypertrophy and to determine the underlying molecular mechanisms. For this purpose, male albino rats were treated daily with either Cymbopogon proximus essential oil (800 μl/kg/day, ip), isoproterenol (5 mg/kg/day, ip), or the combination of both. Oil administration was started four days prior to isoproterenol administration and continued concurrently thereafter for another three days. All animal groups were euthanized 24 hours after the last dose of treatment. Thereafter, the hearts were harvested and heart weight to body weight (HW:BW) ratios were measured and sections of hearts were stained with Masson's trichrome and H&E to assess cardiac fibrosis and morphology. Our results showed that isoproterenol alone resulted in a significant increase in HW:BW ratio and marked myocardial fibrosis in treated rats. On the other hand, treatment with Cymbopogon proximus essential oil significantly reduced the isoproterenol‐mediated increase in HW:BW ratio by 55%. However, oil treatment did not affect isoproterenol mediated‐increase in myocardial fibrosis. Conclusion Cymbopogon proximus essential oil partly protects against isoproterenol‐induced cardiac hypertrophy with no effect on cardiac fibrosis. These findings provide support for the promising therapeutic effects of Cymbopogon proximus on cardiac diseases. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

et al. 2020

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“…Essential oil is extracted from Cymbopogon species by the steam distillation method, and this oil is used in perfumery, soap, cosmetics, floor cleaner and flavouring industries throughout the world (Dutta et al 2017, Baruah et al 2017. Different chemical constituents,viz., methyl eugenol, myrcene, geraniol, elemicin, citral, linalool, geranyl acetate, methyl isoeugenol, etc., are present in the essential oils of this genus (Dutta et al 2016, Dutta et al 2017. Among them, methyl eugenol, an important chemical constituent belonging to the phenylpropanoid group, is found in different spices, vegetables, and herbs (Linchtenstein and Casida 1963).…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel germplasm (Jor Lab L-9) of lemon grass(Cymbopogon khasianus)rich in methyl eugenol

Lal

Munda

Dutta

et al. 2020

Crop Breed. Appl. Biotechnol.

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“…It has quasiubiquitous distribution in Burkina Faso, and even settles in environments apparently less favorable to plants. Like its ubiquitous distribution, the data from literature demonstrated that Cymbopogon species including C. schoenanthus possess various biological properties such as anti-bacterial (Hashim et al, 2017;Hellali et al, 2016), anti-diarrheal, anti-amoebic, anti-filarial, anti-fungal, antiinflammatory, anti-mutagenicity, anti-malarial, antioxidants (Hellali et al, 2016), hypoglycaemic (Dutta et al, 2016), and spasmolytic (Pavlović et al, 2017). Furthermore, studies by different researchers indicate the presence of several chemical groups such as tannins, saponins, saponin glycosides, flavonoids, alkaloids, triterpens, cardiac glycosides, glycosides, steroids and volatile oils in the plant (Pavlović et al, 2017;Amina et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Safety assessment of Cymbopogon shoenanthus (L.) Spreng. (Poaceae) essential oils: Oral toxicity, dermal and eye irritancy investigations

Ilboudo¹,

OuÃ©draogo²,

Sawadogo³

et al. 2019

J. Toxicol. Environ. Health Sci.

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The side effects prediction is a regulatory requirement prior the effective use of a new product as drug or pesticide constituent is allowed. The handling hazards of Cymbopogon schoenanthus essential oils (CSEO) were determined by investigating their acute and subacute toxicities as well as irritancy potential for eye and skin in compliance with the Organization for Economic Cooperation and Development guidelines. In mice, the essential oils did not induce mortality at the limit single dose of 2000 mg/kg b.w., meaning that the test product estimated LD 50 is 5000 mg/kg b.w. In the 28 days subacute oral toxicity study in rats, there was no mortality observed for all tested doses in both sex. Furthermore, besides body weight gain that slightly dropped, there was no significant difference observed in food and water consumption, relative organs weight, and blood biochemical profile in test animals, compared to the control. No eye irritant reaction was shown in the rabbits exposed to CSEO. To assess dermal irritation, rabbits were dermally exposed to CSEO for 4 h. The results showed that no adverse reactions such as erythema and edema were observed throughout the test. Based on these findings, CSEO do not cause either oral toxicity up to 28 days in repeated administration, nor dermal and eye irritation, and seems to be safe for animal in the study conditions. These results constitute a new scientific support for the safe use of C. scheonanthus essential oils as alternatives to synthetic pesticides. However, for further clinical relevance of the results and complete toxicological profile elucidation, toxicity studies must be extended to long term toxicity test as subchronic and chronic toxicities, reprotoxicity, carcinogenicity, teratogenicity, and mutagenicity investigations.

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A Short Review on Chemical Composition Therapeutic Use and Enzyme Inhibition Activities of Cymbopogon species

Cited by 31 publications

References 0 publications

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

Identification of a novel germplasm (Jor Lab L-9) of lemon grass(Cymbopogon khasianus)rich in methyl eugenol

Safety assessment of Cymbopogon shoenanthus (L.) Spreng. (Poaceae) essential oils: Oral toxicity, dermal and eye irritancy investigations

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