A Seventeen-Year Epidemiological Surveillance Study of Borrelia burgdorferi Infections in Two Provinces of Northern Spain

Lledó, Lourdes; Gegúndez, María Isabel; Giménez-Pardo, Consuelo; Álamo, Rufino; Fernández‐Soto, Pedro; Núncio, Maria Sofia; Saz, José Vicente

doi:10.3390/ijerph110201661

Cited by 17 publications

(25 citation statements)

References 29 publications

(33 reference statements)

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“…Numerous studies have been conducted on the seroprevalence of LB in Europe. The seroprevalence of B. burgdorferi IgG was reported to be 54% in Austria in 2006 ( 19 ), 2.27% in Northern Italy in 2010 ( 20 ), 25% in Southern Poland in 2009 ( 21 ), 9.4% in Germany ( 22 ), 9.6% in Western Norway ( 23 ), and 9.6% in Northern Spain ( 24 ). In a study carried out in eight provinces in China, the seroprevalence of B. burgdorferi IgG was 3-15% ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…When the IgG seroprevalence was examined according to sex, it was more common in men in the USA ( 4 ), Austria ( 19 ), Southern Poland ( 21 ), Germany ( 22 ), Western Norway ( 23 ), and China ( 25 ), whereas in Northern Spain ( 24 ) it was more common among women; meanwhile the incidence was almost the same in men and women in South Sweden ( 26 ). In studies conducted in Turkey, it was reported as being more common among men in Düzce ( 14 ), and more common among women in Antalya ( 17 ) and Samsun ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

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Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Cora¹,

Kaklıkkaya²,

Topbaş³

et al. 2017

Balkan Med J

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Background:Lyme borreliosis is a tick-borne, multi-systemic infectious disease that is thought to be wide spread in Turkey even though studies on its seroprevalence are limited.Aims:To determine the seroprevalence of Lyme borreliosis in part of north-eastern Tur-key (in the city of Trabzon), and to identify possible relationships between seropositivity and various factors such as location, gender, age group, occupation, income, and educational level.Study Design:Retrospective cross-sectional study.Methods:A total of 884 blood samples collected from provincial and district health centers serving a population of about 800,000 were included in this study. ELISA was used to determine the anti-Borrelia IgG antibody levels in the samples. Samples that yielded positive results by ELISA were further subjected to western blot (WB).Results:IgG antibodies were found in 128 samples (14.5%). Statistical analysis revealed significant differences between age groups and educational levels in terms of the incidence of seropositivity, whereas location, gender, occupational group and income level had no effect (p<0.001, p<0.001, p=0.948, p=0.645, p=0.131, p=0.080 respectively).Conclusions:The risk of contracting Lyme borreliosis in Trabzon is high, and necessary measures need to be taken to avoid the spread of disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Cora¹,

Kaklıkkaya²,

Topbaş³

et al. 2017

Balkan Med J

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“…reticulatus ticks, but this vector is not competent to transmit Borrelia spp. [ 14 , 49 ]. In our study, D .…”

Section: Discussionmentioning

confidence: 99%

Comparative Metagenomic Profiling of Symbiotic Bacterial Communities Associated with Ixodes persulcatus, Ixodes pavlovskyi and Dermacentor reticulatus Ticks

et al. 2015

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Ixodes persulcatus, Ixodes pavlovskyi, and Dermacentor reticulatus ticks inhabiting Western Siberia are responsible for the transmission of a number of etiological agents that cause human and animal tick-borne diseases. Because these ticks are abundant in the suburbs of large cities, agricultural areas, and popular tourist sites and frequently attack people and livestock, data regarding the microbiomes of these organisms are required. Using metagenomic 16S profiling, we evaluate bacterial communities associated with I. persulcatus, I. pavlovskyi, and D. reticulatus ticks collected from the Novosibirsk region of Russia. A total of 1214 ticks were used for this study. DNA extracted from the ticks was pooled according to tick species and sex. Sequencing of the V3-V5 domains of 16S rRNA genes was performed using the Illumina Miseq platform. The following bacterial genera were prevalent in the examined communities: Acinetobacter (all three tick species), Rickettsia (I. persulcatus and D. reticulatus) and Francisella (D. reticulatus). B. burgdorferi sensu lato and B. miyamotoi sequences were detected in I. persulcatus and I. pavlovskyi but not in D. reticulatus ticks. The pooled samples of all tick species studied contained bacteria from the Anaplasmataceae family, although their occurrence was low. DNA from A. phagocytophilum and Candidatus Neoehrlichia mikurensis was first observed in I. pavlovskyi ticks. Significant inter-species differences in the number of bacterial taxa as well as intra-species diversity related to tick sex were observed. The bacterial communities associated with the I. pavlovskyi ticks displayed a higher biodiversity compared with those of the I. persulcatus and D. reticulatus ticks. Bacterial community structure was also diverse across the studied tick species, as shown by permutational analysis of variance using the Bray-Curtis dissimilarity metric (p = 0.002). Between-sex variation was confirmed by PERMANOVA testing in I. persulcatus (p = 0.042) and I. pavlovskyi (p = 0.042) ticks. Our study indicated that 16S metagenomic profiling could be used for rapid assessment of the occurrence of medically important bacteria in tick populations inhabiting different natural biotopes and therefore the epidemic danger of studied foci.

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“…Adults are exophilic and feed on large ungulates, carnivores, horses or wild boars [ 24 – 28 ]. This tick species attacks humans very rarely [ 29 , 30 ]. However, D. reticulatus plays an important role in the maintenance of TBP's of veterinary and medical importance in the environment and their transmission between vertebrate hosts that are susceptible to infection or serve as efficient reservoirs.…”

Section: Introductionmentioning

confidence: 99%

Pathogens vectored by the tick, Dermacentor reticulatus, in endemic regions and zones of expansion in Poland

et al. 2015

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BackgroundDermacentor reticulatus plays an important role in the maintenance of pathogens of medical and veterinary importance in the environment. Currently two isolated populations of D. reticulatus are present in Poland –Western and Eastern. The range of the Eastern population covers endemic areas in eastern Poland but this population is expanding westwards creating an expansion zone in the centre of the country. The expansion zone in western Poland is occupied by the recently discovered Western population, spreading eastwards.MethodsQuesting adult ticks (n = 2585) were collected in 2012–2014 in endemic regions of north-eastern (Warmińsko-Mazurskie Voivodeship) and central Poland (Masovian Voivodeship) and in the expansion zones in central and western Poland, in the region between the Vistula River and the western border of the country. Amplification of Babesia, Rickettsia spp. and Borrelia burgdorferi sensu lato DNAs was performed using specific starters. RNA of the TBE virus was detected using RT-PCR and representative PCR products were sequenced and compared with sequences deposited in GenBank.ResultsOf the total 2585 examined ticks, 1197 (46.3 %) were infected with at least one pathogen. Overall prevalence of pathogens was 4.18 % (108/2585) for Babesia spp., 44.10 % (1140/2585) for Rickettsia spp., 0.09 % (1/1107) for Borrelia afzelii and 7.6 % (7/92) for TBEV. Sequence analysis of DNA showed 99.86 % similarity to R. raoulti and 99.81 % to B. canis. One male from north-eastern Poland was infected with B. microti.Prevalence of R. raoulti was highest in the Western population (52.03 %) and lowest in the Eastern population in north-eastern Poland (34.18 %). Babesia canis was not detected in 592 ticks collected in the Western population, while in the Eastern population overall prevalence was 5.42 %. There were significant differences in the prevalence of B. canis between tick samples from northern (0.68 %), central (1.18 %) and southern (14.8 %) areas of the expansion zone in central Poland.ConclusionsOur study found significant differences between the range and prevalence of vectored pathogens in D. reticulatus from the endemic areas and newly inhabited expansion zones. The differences were likely associated with the different time of settlement or ‘source’ of ticks populations, the Eastern and the Western one.

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A Seventeen-Year Epidemiological Surveillance Study of Borrelia burgdorferi Infections in Two Provinces of Northern Spain

Cited by 17 publications

References 29 publications

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Comparative Metagenomic Profiling of Symbiotic Bacterial Communities Associated with Ixodes persulcatus, Ixodes pavlovskyi and Dermacentor reticulatus Ticks

Pathogens vectored by the tick, Dermacentor reticulatus, in endemic regions and zones of expansion in Poland

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