A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells

Bocca, Claudia; Gabriel, Ludovica; Bozzo, Francesca; Miglietta, Antonella

doi:10.1016/j.cbi.2003.10.008

Cited by 63 publications

(35 citation statements)

References 19 publications

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“…Costunolide also showed anti-cancer activity by exerting antiproliferative effects in MCF-7, human breast cancer cells by interacting with microtubule proteins, and by inducing apoptosis in HL-60 cells, by suppressing Bcl-2 protein expression and by activating caspase-3. 100 Another SL, helenalin (51) isolated from Arnica montana exhibited anti-inflammatory activity. LyX et al 101 reported that helenalin selectively inhibited the activation of the transcription factor NF-kB, but later on the same group described the mechanism of its action as the selective modification of the p65 subunit of the NF-kB, most probably by bifunctional alkylation of two specific cysteinyl residues in the DNA-binding region, thereby inhibiting DNA NF-kB, EMSA 10 Ã…”

Section: Terpenoidsmentioning

confidence: 99%

Recent developments in anti‐inflammatory natural products

Gautam

Jachak

2009

Medicinal Research Reviews

393

230

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Many of the inflammatory diseases are becoming common in aging society throughout the world. The clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Since ancient times traditional medicines and phytopharmaceuticals are being used for the treatment of inflammatory and other disorders. The present review article describes anti-inflammatory natural products derived from plants and marine sources reported during last decade. The compounds described belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds. The attempt is also being made to enumerate the possible leads, e.g. curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid, for further development with the help of structure-activity relationship (SAR) studies and their current status. In addition SAR studies carried out on the anti-inflammatory activity of flavonoid compounds and clinical studies performed on anti-inflammatory natural products are also discussed.

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Section: Terpenoidsmentioning

confidence: 99%

Recent developments in anti‐inflammatory natural products

Gautam

Jachak

2009

Medicinal Research Reviews

393

230

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“…Furthermore, costunolide potentiated 1,25-(OH)2D3-induced differentiation in HL-60 promyelocytic leukemia cells (Choi et al, 2002b;Kim et al, 2008;Kim et al, 2002), via the interference with NF-κB activation. Further studies demonstrate that costunolide has antitumor potential by inhibiting proliferation, inducing apoptosis and reducing invasion and metastasis of a wide variety of tumor cells, including breast cancer cells (Bocca et al, 2004;Choi et al, 2005;Choi et al, 2011), hepatocellular carcinoma cells (Chen et al, 1995;Liu et al, 2011a;Sun et al, 2003), prostate cancer cells (Hsu et al, 2011), leukemia cells (Choi et al, 2002a;Choi and Lee, 2009;Choi et al, 2002b;Hibasami et al, 2003;Kanno et al, 2008;Kim et al, 2008;Kim et al, 2002;Kim et al, 2011b;Komiya et al, 2004;Lee et al, 2001;Song et al, 2001;Srivastava et al, 2006), gastric cancer cells (Ko et al, 2005;Rasul et al, 2011), colon cancer cells (Kawamori et al, 1995;Mori et al, 1994), melanoma cells (Chen et al, 2007;Park et al, 2001b), cervical cancer cells (Sun et al, 2003), KB and P388 tumor cell (Mondranondra et al, 1990), and platinum-resistant human ovarian cancer cells . It was also reported that costunolide inhibited angiogenic response by blocking the angiogenic factor signaling pathway (Jeong et al, 2002) and microtubule-interactting activity of costunolide (Bocca et al, 2004).…”

Section: Biological Functionsmentioning

confidence: 99%

Costunolide: A novel anti-cancer sesquiterpene lactone

Rasul

Parveen

2012

Bangladesh J Pharmacol

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Costunolide: A novel anti Costunolide: A novel anti Costunolide: A novel anti---cancer cancer cancer sesquiterpene lactone sesquiterpene lactone sesquiterpene lactone BJP IntroductionCancer is the leading cause of death and represents one of the most threatening diseases worldwide. In the recent report, it has been estimated that 12.7 million new cancer cases and 7.6 million cancer deaths occur in 2008, with 56% of new cancer cases and 63% of the cancer deaths occurring in the less developed regions of the world (Ferlay et al., 2010). Throughout the history of civilization, the human have relied on natural products as a primary source of medicine. Herbal medicines have been proven to be an important source of novel agents with a pharmaceutical potential. Many anti-cancer drugs in current use are either natural products or are derived from natural products. Herbal medicines, such as paclitaxel, camptothecin, vinca alkaloids, and etoposide hold great potential as promising agents for the treatment of cancer (Cragg and Newman, 2005). Natural products have tradition-ally provided a rich source of drugs for many diseases, including cancer and plants are an important source of novel natural products (Amin et al., 2009). In 2008, of the 225 drugs being developed, 164 were of natural origin, with 108 being derived from plants, 25 from bacterial sources, 7 from fungal and 24 from animal sources. And, to throw some more numbers around, of the 108 plant-based drugs, 46 were in preclinical development, 14 in phase I, 41 in phase II, 5 in phase III and two had already reached pre-registration stage (Harvey, 2008). David Newman and Gordon Cragg (Newman and Cragg, 2007) found that of 155 FDA-approved small molecule anti-cancer drugs, 47% were either natural products or directly derived there from.C o s t u n o l i d e ( 6 E , 1 0 E , 1 1 a R ) -6 , 1 0 -d i m e t h y l -3 -methylidene-3a, 4,5,8,9,11a-hexahydrocyclodeca [b] furan-2-one) is a sesquiterpene lactone. It is a colorless crystalline powder with molecular formula of C15H20O2 and molecular weight of 232.318 g/mol (Figure 1). This review is aimed to summarize the recent researches on costunolide focusing on anti-cancer activity and to lay emphasis on molecular mechanisms which suggests a promising for such pursuits in oncology. Literature was searched through Pub Med, Scopus and Elsevier Science Direct Journal. Access to the Elsevier Science Direct Journal was made possible through library of AbstractCurrently an ample interest is found among oncologists to explore anti-cancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plantderived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anti-cancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor...

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“…23,24) In a recent study, costunolide interacted with microtubule proteins and inhibited the growth of MCF-7 breast cancer cells. 25) Furthermore, it was found that costunolide plays an anti-inflammatory role in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by suppressing the NFkB signaling pathway. 20) Phosphorylation of inhibitory kappa B (IkB) proteins and subsequent inhibition of the nuclear translocation of NFkB complex have also been observed after treatment with costunolide.…”

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confidence: 99%

Costunolide Induces Apoptosis in Human Endometriotic Cells through Inhibition of the Prosurvival Akt and Nuclear Factor Kappa B Signaling Pathway

Kim

Yang

Lee

et al. 2011

Biological & Pharmaceutical Bulletin

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Endometriosis, a disease affecting 5-15% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Costunolide, a sesquiterpene lactone, has anti-proliferative and pro-apoptotic activities that may be efficacious in therapy for endometriosis. In the present study, we investigated the effect of costunolide on the cell growth and apoptosis of endometriotic cells. We found that costunolide significantly inhib-

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A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells

Cited by 63 publications

References 19 publications

Recent developments in anti‐inflammatory natural products

Recent developments in anti‐inflammatory natural products

Costunolide: A novel anti-cancer sesquiterpene lactone

Costunolide Induces Apoptosis in Human Endometriotic Cells through Inhibition of the Prosurvival Akt and Nuclear Factor Kappa B Signaling Pathway

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