A sensitive method for the determination of iodine containing diagnostic agents in aqueous matrices using LC-electrospray-tandem-MS detection

Abstract

Iodinated contrast media belong to the most frequently applied compounds in medicine. They exhibit a high polarity and are very persistent against metabolism by the organism and environmental degradation. A sensitive method for the determination of five iodinated contrast media in aqueous matrices is described. Solid phase extraction utilizing Isolute ENV+ material was used for sample enrichment. The contrast media were partially separated on a RP-C18 column, and detection was achieved using electrospray-tandem MS (API III plus and API 365) allowing the sensitive quantitation of these compounds down to the lower ng/L range. The recovery rates generally exceeded 70%, for spiked surface water as well as tap water. The analytes were detected in native samples such as municipal sewage treatment plant (STP) effluent, the river Rhine and even in tap water.

Novel applications of highly sensitive liquid chromatography/mass spectrometry/mass spectrometry for the direct detection of ultra‐trace levels of contaminants in water

“…7 Their analysis also involves LC/MS after pre-concentration. 8 Diclofenac and carbamazepine were selected as representatives of a large number of pharmaceutically active compounds, recently analysed by LC/MS. 9 …”

Présence et devenir des médicaments dans les eaux usées urbaines, une analyse bibliographique

“…Environ 30 à 90 % des doses administrées de tous les antibiotiques consommés par les êtres humains et les animaux sont rejetées sous forme de substances actives (TERNES, 2001). Certains antibiotiques comme la pénicilline sont très consommés mais ils ne peuvent être détectés dans les environnements aquatiques qu'en faible concentration car ils sont très facilement hydrolysés (HIRSCH et al, 2000).…”

“…Sauf exception (HIRSCH et al, 2000), la charge en antibiotiques des eaux usées urbaines est en général faible. Cependant, elle est forte dans les effluents des hôpitaux (WITTERS et al, 2004).…”

Analytical Methods for Polar Pollutants

“…Then, organic amines in their protonated form can be added to utilize IP-RPLC. This strategy has been used for the LC-MS analysis of bile acid conjugates using dibutylamine [159], for X-ray agents with a (non-volatile) tetraalkylammonium cation [160], and for acidic pharmaceuticals (antiphlogistics and lipid regulators, Fig. 1.11) and their more polar metabolites with volatile TrBA [54,161].…”