A sensitive LC–ESI-MS method for the determination of indapamide in human plasma: Method and clinical applications

Identification and quantitative determination of a major circulating metabolite of gambogic acid in human

“…In vitro study [12] indicates that GA is rapidly metabolized in rat liver microsome and a hydration metabolite is crucial for the elimination of GA and CYP1A2 is responsible for this pathway. In vivo studies [13,14] suggest that GA is metabolized to two main phase I metabolites in rat bile and their structures are elucidated as 10-hydroxygambogic acid (10-OHGA, see Fig.…”

Determination of indapamide in human serum using 96-well solid-phase extraction and high-performance liquid chromatography–tandem mass spectrometry (LC–MS/MS)

“…LC-MS methods for the quantitation of indapamide in blood have been reported frequently in recent years [6][7][8][9][10]. The LC-MS method has high specificity and sensitivity, since the limit of quantification of indapamide was found to be 0.5-2 ng/ml in these reports.…”

Determination of gambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization–mass spectrometry

“…Although MS/MS is not available on the instrument used in this experiment, there are still fragment ions [21], deprotonated molecule ions [22,23], and protonated molecule ions [24,25] that can be selected as the target ions of the analytes in the SIM. By adjusting the fragmentor voltage to different values, the different base peaks (the highest ion peak in the mass spectrum, which can be selected as the target ions of the analytes) were obtained.…”