A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population

Wong, Benjamin C Y; Wong, Wai Man; Cheung, Kwok Leung; Tong, Teresa; Rozen, Paul; Young, Graeme P.; Chu, Kent‐Man; Ho, J.C.M.; Law, Wai‐Lun; Tung, Helen; Lai, K. C.; Hu, Whc; Chan, Chi Kuen; Lam, Shiu‐Kum

doi:10.1046/j.1365-2036.2003.01783.x

Cited by 68 publications

(47 citation statements)

References 16 publications

(19 reference statements)

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“…Several studies have previously shown that the Hemoccult II Sensa test can give unexpectedly high positive rates in certain populations, probably because of failure to follow dietary recommendations. 13,34 FITs are not subject to such an effect in those populations. 13,34 Although this study has been directed toward examining relative effectiveness for detection of neoplasia, the FIT technology also has distinct behavioral advantages.…”

Section: Discussionmentioning

confidence: 91%

“…13,34 FITs are not subject to such an effect in those populations. 13,34 Although this study has been directed toward examining relative effectiveness for detection of neoplasia, the FIT technology also has distinct behavioral advantages. Patients are more likely to participate, i.e., complete and return the test sampling kit, when diet and drug restrictions are removed 20 and when a simpler sampling procedure, such as the brush method combined with reduced number of samples, is used.…”

Section: Discussionmentioning

confidence: 91%

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Comparison of a brush‐sampling fecal immunochemical test for hemoglobin with a sensitive guaiac‐based fecal occult blood test in detection of colorectal neoplasia

Smith

Young

Cole

et al. 2006

Cancer

146

125

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In this article, the effect of sample size on the degassing behavior of closed‐cell low density polyethylene (LDPE) foam under long‐term compressive static loading is presented. The creep response was modeled by assuming isothermal compression of the gas. The change in gas pressure with time was obtained and the effective diffusion coefficients were calculated from pressure decrease using an analytical solution of the diffusion equation, and were found to increase when the sample size was reduced. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

Comparison of a brush‐sampling fecal immunochemical test for hemoglobin with a sensitive guaiac‐based fecal occult blood test in detection of colorectal neoplasia

Smith

Young

Cole

et al. 2006

Cancer

146

125

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“…The lower specificity of our results may be explained by the fact that the Chinese diet often contains components that may cause a false-positive CFOBT. 18 It appears that the third sample had more false-positive finding than the first 2 samples combined. The reason for that is unclear.…”

Section: Discussionmentioning

confidence: 96%

New immunochemical fecal occult blood test with two‐consecutive stool sample testing is a cost‐effective approach for colon cancer screening: Results of a prospective multicenter study in Chinese patients

Liu

Wang

et al. 2006

Intl Journal of Cancer

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The purpose of the study is to evaluate a new immunochemical fecal occult blood test method (Hemosure IFOBT), and compare it to the Guaiac-based chemical method (CFOBT) for colorectal cancer detection. A hypothetical sequential method (SFOBT), in which IFOBT was used only as a confirmatory test for CFOBT, was also evaluated. A total of 324 patients were recruited from 5 major hospitals in Beijing, China. For each patient, 3 consecutive stool samples were collected for simultaneous CFOBT and IFOBT tests, followed by colonoscopic examination. We compared the sensitivity and specificity of the 3 methods (CFOBT, IFOBT and SFOBT) in two settings, with the first 2 consecutive samples versus all 3 samples. Although the sensitivity for the detection of cancer and large (>20 mm) or multiple adenoma was similar for all 3 methods in the three-sample setting, in the two-sample setting IFOBT had higher sensitivity than SFOBT for detecting cancer (87.8% vs. 75.5%, respectively, p < 0.05) and large (>20 mm) or multiple adenomas (65.4% vs. 42.3%, respectively, p < 0.05). The IFOBT also had a higher specificity than the CFOBT (89.2% vs. 75.5%, respectively, p < 0.01) in ''normal'' individuals defined by colonoscopy in the three-sample setting. Comparing two-sample setting to the three-sample setting, both CFOBT and SFOBT showed significant loss of sensitivity for the detection of cancer as well as adenoma, whereas the sensitivity for IFOBT did not change significantly. Overall, IFOBT with two-sample testing showed compatible sensitivity and specificity to the three-sample testing, and had a lower relative cost per cancer detected than the three-sample testing. In conclusion, the new Hemosure IFOBT with two consecutive stool samples appears to be the most costeffective approach for colon cancer screening. ' 2006 Wiley-Liss, Inc.

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“…In this review, we have focused on studies that compared different FIT with Hemoccult SENSA since at present it has the highest sensitivity of currently marketed gFOBT. 49,[54][55][56][57][58] Based on data from these 6 studies, it appears that there are no clear patterns of superior performance in overall test performance between a high-sensitivity guaiac-based test (Hemoccult SENSA) and a variety of FIT.…”

Section: Fitmentioning

confidence: 99%

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

Levin

Lieberman

McFarland

et al. 2008

CA: A Cancer Journal for Clinicians

1,555

916

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In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed among men and women and the second leading cause of death from cancer. CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized. In 2006 to 2007, the American Cancer Society, the US Multi Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults. In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy. When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and a screening test that primarily is effective at early cancer detection. It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening. (CA Cancer J Clin 2008;58:130-160.)

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A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population

Cited by 68 publications

References 16 publications

Comparison of a brush‐sampling fecal immunochemical test for hemoglobin with a sensitive guaiac‐based fecal occult blood test in detection of colorectal neoplasia

Comparison of a brush‐sampling fecal immunochemical test for hemoglobin with a sensitive guaiac‐based fecal occult blood test in detection of colorectal neoplasia

New immunochemical fecal occult blood test with two‐consecutive stool sample testing is a cost‐effective approach for colon cancer screening: Results of a prospective multicenter study in Chinese patients

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

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